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Term Description

GSTP1 and APC gene methylation are increase in prostate cancer.
Source: Regenstrief LOINC

Part Descriptions

LP100589-3   GSTP1 gene+APC gene methylation
The detection of methylated APC and GSTP1 DNA in serum correlated with the presence of CTC in the blood of breast cancer patients. Both methylated DNA and CTC correlated with a more aggressive tumor biology and advanced disease. Source: NCBI PubMed, PubMed

LP124510-1   gene methylation
DNA methylation is essential during embryonic development, and patterns of DNA methylation are generally transmitted to daughter cells with a high fidelity. In cancer, aberrant DNA methylation patterns are found in two distinct forms: hypermethylation and hypomethylation. Hypermethylation is one of the major epigenetic modifications that repress transcription via the promoter region of tumor suppressor genes. Hypermethylation typically occurs at CpG islands in the promoter region and is associated with gene inactivation. Hypomethylation, linked to chromosomal instability and loss of imprinting, arises earlier and occurs throughout the progression of cancer.

More specifically, methylated DNA can bind to methyl-CpG-binding domain proteins (MBDs), which recruit additional proteins such as histone deacetylases and other chromatin remodeling proteins that modify histones to form compact, inactive chromatin, termed silent chromatin. Loss of methyl-CpG-binding protein 2 (MeCP2) has been implicated in Rett syndrome; and methyl-CpG-binding domain protein 2 (MBD2) mediates the transcriptional silencing of hypermethylated genes in cancer. Research has suggested that long-term memory storage in humans may be regulated by DNA methylation. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Wikipedia

LOINC Names Get Info

Fully-Specified Name
GSTP1 gene+APC gene methylation:Arb:Pt:Tiss:Ord:Molgen
Long Common Name
GSTP1 gene+APC gene methylation [Presence] in Tissue by Molecular genetics method
Short Name
GSTP1+APC gene methylation Tiss Ql
Display Name
GSTP1 gene+APC gene methylation Molgen Ql (Tiss)
Consumer Name Alpha Get Info
GSTP1 gene+APC gene methylation, Tissue

Part Model Get Info

  • Component
    GSTP1 gene+APC gene methylation
    LP100589-3
    • Analyte
      GSTP1 gene+APC gene methylation
      LP100589-3
      • Component Numerator
        GSTP1 gene+APC gene methylation
        LP100589-3
        • Component Numerator Core
          GSTP1 gene+APC gene methylation
          LP100589-3
        • Component Numerator Core Suffix
          NULL
           
      • Component Denominator
        NULL
         
        • Component Denominator Core
          NULL
           
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    Arb
    LP6781-1
  • Time
    Pt
    LP6960-1
  • System
    Tiss
    LP7641-6
    • System Core
      Tiss
      LP7641-6
    • Super System
      NULL
       
  • Scale
    Ord
    LP7751-3
  • Method
    Molgen
    LP6404-0

Example Answer List: LL360-9

Source: Regenstrief Institute
AnswerCodeScoreAnswer ID
PositiveCopyright http://snomed.info/sct ID:10828004 Positive (qualifier value)LA6576-8
NegativeCopyright http://snomed.info/sct ID:260385009 Negative (qualifier value)LA6577-6

Basic Attributes

Class
MOLPATH
Type
Laboratory
First Released
Version 2.32
Last Updated
Version 2.73 (MIN)
Order vs. Observation
Both
Common Test Rank Get Info
14411

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)Gen GSTP1+APC methylace:Arbitrární:Časový bod:Tkáně a stěry:Ordinální:Molekulární genetika
el-GRGreek (Greece)Μεθυλίωση γονιδίου GSTP1 +APC:Arb:Pt:Ιστός:Ord:Μοριακή γενετική
Synonyms: Arb MOLPATH Ord Pt Γονίδιο Γονίδιο APC Ιστός Μεθυλίωση γονιδίου GSTP1 +APC Μοριακή γενετική
es-ESSpanish (Spain)Metilación de gen GSTP1 + gen APC:Arbitrario:Punto temporal:Tejido:Ord:Genética molecular
es-MXSpanish (Mexico)Metilación del gen GSTP1 + gen APC:Arbitrario:Punto temporal:Tejido y frotis:Ordinal:Genética molecular
fr-FRFrench (France)GSTP1+APC gènes méthylation:Arbitraire:Ponctuel:Tissu:Qualitatif:Biologie moléculaire
it-ITItalian (Italy)GSTP1, gene+gene APC, metilazione:Arb:Pt:Tessuto:Ord:Molgen
Synonyms: Arbitrario Gene APC Genetica molecolare Metilazione di gene GSTP1+gene APC Patologia molecolare Punto nel tempo (episodio) Tessuto & Strisci
nl-NLDutch (Netherlands)GSTP1-gen + APC-gen methylatie:aanwezigheid:moment:weefsel en uitstrijkjes:ordinaal:moleculair genetisch onderzoek
Synonyms: APC gen GSTP1 gen+APC gen methylatie molgen
pl-PLPolish (Poland)GSTP1 gen+APC gen metylacja:jednostka umowna:punkt w czasie:tkanka i rozmazy:uporządkowany:genetyka molekularna
Synonyms: diagnostyka molekularna Gen APC Metylacja genu GSTP1 i genu APC;Metylacja genów GSTP1 i APC
ru-RURussian (Russian Federation)GSTP1 ген+APC ген метилирование:Произв:ТчкВрм:Тк:Пор:МолГен
Synonyms: Порядковый Произвольный Ткань и мазки Точка во времени;Момент
tr-TRTurkish (Turkey)GSTP1 geni+APC geni metilasyon:Sç:Zmlı:Doku:Srl:Molgen
zh-CNChinese (China)GSTP1 基因+APC 基因甲基化:任意型:时间点:组织与涂片:序数型:分子遗传学类实验室方法
Synonyms: APC基因;DP2;DP2.5;DP3;FAP;FPC;GS;大肠腺瘤样多发性息肉;大肠腺瘤样多发性息肉病;大肠腺瘤样息肉病;大肠腺瘤状多发性息肉;大肠腺瘤状多发性息肉病;大肠腺瘤状息肉病;家族性腺瘤性息肉病;家族性腺瘤样多发性息肉;家族性腺瘤样多发性息肉病;家族性腺瘤样息肉病;家族性腺瘤状多发性息肉;家族性腺瘤状多发性息肉病;家族性腺瘤状息肉病;结肠的腺瘤样多发性息肉;结肠的腺瘤样多发性息肉病;结肠的腺瘤样息肉病;结肠的腺瘤状多发性息肉;结肠的腺瘤状多发性息肉病;结肠的腺瘤状息肉病;结肠腺瘤病(aden 任意;任意的;人工型 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 分子病理学;分子病理学试验 分子遗传学;分子遗传学方法;分子遗传学类方法;分子遗传学类检验方法;包括 RFL、PCR 及其他方法在内，用于在分子基础上检测遗传属性的方法的大类;聚合酶链反应;聚合酶链式反应 时刻;随机;随意;瞬间 未作说明的组织;组织;组织 & 涂片 遗传基因;遗传因子;吉恩;生物基因

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