LOINC
Version 2.67

59585-0GSTP1 gene+APC gene methylation [Presence] in Tissue by Molecular genetics methodActive

Term Description

GSTP1 and APC gene methylation are increase in prostate cancer.
Source: Regenstrief LOINC

Part Descriptions

LP100589-3   GSTP1 gene+APC gene methylation
The detection of methylated APC and GSTP1 DNA in serum correlated with the presence of CTC in the blood of breast cancer patients. Both methylated DNA and CTC correlated with a more aggressive tumor biology and advanced disease. Source: NCBI PubMed, PubMed

LP124510-1   gene methylation
DNA methylation is essential during embryonic development, and patterns of DNA methylation are generally transmitted to daughter cells with a high fidelity. In cancer, aberrant DNA methylation patterns are found in two distinct forms: hypermethylation and hypomethylation. Hypermethylation is one of the major epigenetic modifications that repress transcription via the promoter region of tumor suppressor genes. Hypermethylation typically occurs at CpG islands in the promoter region and is associated with gene inactivation. Hypomethylation, linked to chromosomal instability and loss of imprinting, arises earlier and occurs throughout the progression of cancer.

More specifically, methylated DNA can bind to methyl-CpG-binding domain proteins (MBDs), which recruit additional proteins such as histone deacetylases and other chromatin remodeling proteins that modify histones to form compact, inactive chromatin, termed silent chromatin. Loss of methyl-CpG-binding protein 2 (MeCP2) has been implicated in Rett syndrome; and methyl-CpG-binding domain protein 2 (MBD2) mediates the transcriptional silencing of hypermethylated genes in cancer. Research has suggested that long-term memory storage in humans may be regulated by DNA methylation. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Wikipedia

Fully-Specified Name

Component
GSTP1 gene+APC gene methylation
Property
Arb
Time
Pt
System
Tiss
Scale
Ord
Method
Molgen

Additional Names

Short Name
GSTP1+APC gene methylation Tiss Ql
Display Name
GSTP1 gene+APC gene methylation Molgen Ql (Tiss)

Basic Attributes

Class
MOLPATH
Type
Laboratory
First Released
Version 2.32
Last Updated
Version 2.32
Order vs. Observation
Both

Example Answer List LL360-9

Source: Regenstrief Institute

Answer Code Score Answer ID
Positive Copyright http://snomed.info/sct ID:10828004 Positive (qualifier value) LA6576-8
Negative Copyright http://snomed.info/sct ID:260385009 Negative (qualifier value) LA6577-6

Language Variants Get Info

zh-CNChinese (CHINA)
GSTP1 基因+APC 基因甲基化:任意型:时间点:组织与涂片:序数型:分子遗传学类实验室方法
nl-NLDutch (NETHERLANDS)
GSTP1-gen + APC-gen methylatie:aanwezigheid:moment:weefsel en uitstrijkjes:ordinaal:moleculair genetisch onderzoek
fr-FRFrench (FRANCE)
GSTP1+APC gènes méthylation:Arbitraire:Ponctuel:Tissu:Qualitatif:Biologie moléculaire
it-ITItalian (ITALY)
GSTP1, gene+gene APC, metilazione:Arb:Pt:Tessuto:Ord:Molgen
pt-BRPortuguese (BRAZIL)
ru-RURussian (RUSSIAN FEDERATION)
GSTP1 ген+APC ген метилирование:Произв:ТчкВрм:Тк:Пор:МолГен
es-ESSpanish (SPAIN)
Metilación de gen GSTP1 + gen APC:Arbitrario:Punto temporal:Tejido:Ord:Genética molecular
tr-TRTurkish (TURKEY)
GSTP1 geni+APC geni metilasyon:Sç:Zmlı:Doku:Srl:Molgen

LOINC FHIR® API Example - CodeSystem Request Get Info

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=59585-0