Version 2.77

Term Description

GSTP1 and APC gene methylation are increase in prostate cancer.
Source: Regenstrief LOINC

Part Descriptions

LP100589-3   GSTP1 gene+APC gene methylation
The detection of methylated APC and GSTP1 DNA in serum correlated with the presence of CTC in the blood of breast cancer patients. Both methylated DNA and CTC correlated with a more aggressive tumor biology and advanced disease. Source: NCBI PubMed, PubMed

LP124510-1   gene methylation
DNA methylation is essential during embryonic development, and patterns of DNA methylation are generally transmitted to daughter cells with a high fidelity. In cancer, aberrant DNA methylation patterns are found in two distinct forms: hypermethylation and hypomethylation. Hypermethylation is one of the major epigenetic modifications that repress transcription via the promoter region of tumor suppressor genes. Hypermethylation typically occurs at CpG islands in the promoter region and is associated with gene inactivation. Hypomethylation, linked to chromosomal instability and loss of imprinting, arises earlier and occurs throughout the progression of cancer.

More specifically, methylated DNA can bind to methyl-CpG-binding domain proteins (MBDs), which recruit additional proteins such as histone deacetylases and other chromatin remodeling proteins that modify histones to form compact, inactive chromatin, termed silent chromatin. Loss of methyl-CpG-binding protein 2 (MeCP2) has been implicated in Rett syndrome; and methyl-CpG-binding domain protein 2 (MBD2) mediates the transcriptional silencing of hypermethylated genes in cancer. Research has suggested that long-term memory storage in humans may be regulated by DNA methylation. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See for details. Source: Wikipedia, Wikipedia

Fully-Specified Name

GSTP1 gene+APC gene methylation

Additional Names

Short Name
GSTP1+APC gene methylation Tiss Ql
Display Name
GSTP1 gene+APC gene methylation Molgen Ql (Tiss)
Consumer Name Alpha Get Info
GSTP1 gene+APC gene methylation, Tissue

Example Answer List: LL360-9

Source: Regenstrief Institute
Answer Code Score Answer ID
PositiveCopyright ID:10828004 Positive (qualifier value) LA6576-8
NegativeCopyright ID:260385009 Negative (qualifier value) LA6577-6

Basic Attributes

First Released
Version 2.32
Last Updated
Version 2.73
Order vs. Observation
Common Test Rank Get Info

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) Metilación de gen GSTP1 + gen APC:Arbitrario:Punto temporal:Tejido:Ord:Genética molecular
es-MX Spanish (Mexico) Metilación del gen GSTP1 + gen APC:Arbitrario:Punto temporal:Tejido y frotis:Ordinal:Genética molecular
fr-FR French (France) GSTP1+APC gènes méthylation:Arbitraire:Ponctuel:Tissu:Qualitatif:Biologie moléculaire
it-IT Italian (Italy) GSTP1, gene+gene APC, metilazione:Arb:Pt:Tessuto:Ord:Molgen
Synonyms: Arbitrario Gene APC Genetica molecolare Metilazione di gene GSTP1+gene APC Patologia molecolare Punto nel tempo (episodio) Tessuto & Strisci
nl-NL Dutch (Netherlands) GSTP1-gen + APC-gen methylatie:aanwezigheid:moment:weefsel en uitstrijkjes:ordinaal:moleculair genetisch onderzoek
Synonyms: APC gen GSTP1 gen+APC gen methylatie molgen
pt-BR Portuguese (Brazil) GSTP1 gene+APC gene metilação::Pt:Tecido:Ord:Genética molecular
ru-RU Russian (Russian Federation) GSTP1 ген+APC ген метилирование:Произв:ТчкВрм:Тк:Пор:МолГен
Synonyms: Порядковый Произвольный Ткань и мазки Точка во времени;Момент
tr-TR Turkish (Turkey) GSTP1 geni+APC geni metilasyon:Sç:Zmlı:Doku:Srl:Molgen
zh-CN Chinese (China) GSTP1 基因+APC 基因甲基化:任意型:时间点:组织与涂片:序数型:分子遗传学类实验室方法
Synonyms: APC基因;DP2;DP2.5;DP3;FAP;FPC;GS;大肠腺瘤样多发性息肉;大肠腺瘤样多发性息肉病;大肠腺瘤样息肉病;大肠腺瘤状多发性息肉;大肠腺瘤状多发性息肉病;大肠腺瘤状息肉病;家族性腺瘤性息肉病;家族性腺瘤样多发性息肉;家族性腺瘤样多发性息肉病;家族性腺瘤样息肉病;家族性腺瘤状多发性息肉;家族性腺瘤状多发性息肉病;家族性腺瘤状息肉病;结肠的腺瘤样多发性息肉;结肠的腺瘤样多发性息肉病;结肠的腺瘤样息肉病;结肠的腺瘤状多发性息肉;结肠的腺瘤状多发性息肉病;结肠的腺瘤状息肉病;结肠腺瘤病(aden 任意;任意的;人工型 依次型;分类顺序型;定性的;序数型(或称等级型);性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 分子病理学;分子病理学试验 分子遗传学;分子遗传学方法;分子遗传学类方法;分子遗传学类检验方法;包括 RFL、PCR 及其他方法在内,用于在分子基础上检测遗传属性的方法的大类;聚合酶链反应;聚合酶链式反应 时刻;随机;随意;瞬间 未作说明的组织;组织;组织 & 涂片 遗传基因;遗传因子;吉恩;生物基因

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