LOINC
Version 2.69

60020-5Lactate dehydrogenase [Enzymatic activity/volume] in Peritoneal fluid by Pyruvate to lactate reactionActive

Part Descriptions

LP15033-1   Lactate dehydrogenase
Lactate dehydrogenase (LDH) is an enzyme (EC 1.1.1.27) present in a wide variety of organisms, including plants and animals. It catalyses the interconversion of pyruvate and lactate with concomitant interconversion of NADH and NAD+. As it can also catalyze the oxidation of hydroxybutyrate, it is occasionally called hydroxybutyrate dehydrogenase (HBD). Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, D-lactate (Wikipedia)

LP15033-1   Lactate dehydrogenase
Lactate dehydrogenase (LDH, or also called LD) is an oxidoreductase (LD: EC 1.1.1.27) and is the most important clinically of several dehydrogenases occurring in human serum. LDH catalyses the interconversion of pyruvate and lactate with concomitant interconversion of NADH and NAD. When disease, injury, or toxic material damages tissues, cells release LDH into the bloodstream. Since LDH is a fairly stable enzyme, it has been widely used to evaluate the presence of damage and toxicity of tissue and cells. LDH is cytoplasmic in its cellular location and in any one tissue is composed of one or two of five possible isoenzymes. While many of its clinical applications involve quantification of one or more specific serum isoenzymes, an estimate of total LDH is usually required. Lactate dehydrogenase catalyzes the reversible reaction: L-lactate + NAD <--> pyruvate + NADH. Testing methods either measure the increase in NADH produced in the lactate-to-pyruvate reaction or the decrease in NADH produced in the pyruvate-to-lactate reaction. [PMID: 3882046] . Reference ranges are highly method dependent. The pyruvate-to-lactate reaction is preferred theoretically because the equilibrium constant is large and the rate for any amount of enzyme is 2-3 times faster, thus smaller sample and shorter observation periods are needed. Disadvantages of the pyruvate-to-lactate reaction are loss of linearity as compared with the lactate-to-pyruvate reaction, and greater substrate inhibition of the enzyme. [Tietz Fourth Edition] Source: Regenstrief LOINC

Fully-Specified Name

Component
Lactate dehydrogenase
Property
CCnc
Time
Pt
System
Periton fld
Scale
Qn
Method
Reaction: pyruvate to lactate

Additional Names

Short Name
LDH Prt P to L-cCnc
Display Name
LDH Pyruvate to lactate reaction (Periton fld) [Catalytic activity/Vol]
Consumer Name Alpha
Lactate Dehydrogenase (LDH), Peritoneal Fluid

Basic Attributes

Class
CHEM
Type
Laboratory
First Released
Version 2.34
Last Updated
Version 2.68
Order vs. Observation
Both

Reference Information

Type Source Reference
Webcontent Lab Tests Online®Copyright Copyright © 2001-2019 American Association for Clinical Chemistry Lactate Dehydrogenase (LD)

Language Variants Get Info

zh-CNChinese (China)
乳酸脱氢酶:催化浓度:时间点:腹膜液:定量型:反应: 丙酮酸至乳酸
nl-NLDutch (Netherlands)
lactaatdehydrogenase:enzymatische activiteit/volume:moment:peritoneaalvocht:kwantitatief:reactie: pyruvaat naar lactaat
fr-BEFrench (Belgium)
Lactate déshydrogénase:Concentration catalytique:Temps ponctuel:Liquide péritonéal:Quantitatif:Réaction: pyruvate en lactate
fr-CAFrench (Canada)
Lactate déshydrogénase:Concentration catalytique:Temps ponctuel:Liquide péritonéal:Quantitatif:Réaction: pyruvate en lactate
fr-FRFrench (France)
Lactate déhydrogénase:Catalytique/Volume:Ponctuel:Ascite:Numérique:Réaction : Pyruvate vers Lactate
de-DEGerman (Germany)
Lactatdehydrogenase:KKnz:Pkt:Periton Fl:Qn:Reaktion: Pyruvat zu Lactat
it-ITItalian (Italy)
Lattato deidrogenasi:CCnC:Pt:Liquido peritoneale:Qn:Reazione: piruvato in lattato
pt-BRPortuguese (Brazil)
Lactato dehidrogenase::Pt:LiqPerit:Qn:Reação: Piruvato e Lactato
es-ESSpanish (Spain)
Lactato deshidrogenasa:Concentración Catalítica:Punto temporal:Fluído peritoneal:Qn:Reacción - piruvato lactato
tr-TRTurkish (Turkey)
Laktat dehidrojenaz:KtlKons:Zmlı:Periton sv:Kant:Reaksiyon: piruvat tan laktat a

Example Units

Unit Source
U/L Example UCUM Units
U/L Original Submission

LOINC FHIR® API Example - CodeSystem Request Get Info

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=60020-5