60024-7Lactate dehydrogenase [Enzymatic activity/volume] in Cerebral spinal fluid by Lactate to pyruvate reactionActive
Part Descriptions
LP15033-1 Lactate dehydrogenase
Lactate dehydrogenase (LDH) is an enzyme (EC 1.1.1.27) present in a wide variety of organisms, including plants and animals. It catalyses the interconversion of pyruvate and lactate with concomitant interconversion of NADH and NAD+. As it can also catalyze the oxidation of hydroxybutyrate, it is occasionally called hydroxybutyrate dehydrogenase (HBD).
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Source: Wikipedia, D-lactate (Wikipedia)
LP15033-1 Lactate dehydrogenase
Lactate dehydrogenase (LDH, or also called LD) is an oxidoreductase (LD: EC 1.1.1.27) and is the most important clinically of several dehydrogenases occurring in human serum. LDH catalyses the interconversion of pyruvate and lactate with concomitant interconversion of NADH and NAD. When disease, injury, or toxic material damages tissues, cells release LDH into the bloodstream. Since LDH is a fairly stable enzyme, it has been widely used to evaluate the presence of damage and toxicity of tissue and cells. LDH is cytoplasmic in its cellular location and in any one tissue is composed of one or two of five possible isoenzymes. While many of its clinical applications involve quantification of one or more specific serum isoenzymes, an estimate of total LDH is usually required. Lactate dehydrogenase catalyzes the reversible reaction: L-lactate + NAD <--> pyruvate + NADH. Testing methods either measure the increase in NADH produced in the lactate-to-pyruvate reaction or the decrease in NADH produced in the pyruvate-to-lactate reaction. [PMID: 3882046] . Reference ranges are highly method dependent. The pyruvate-to-lactate reaction is preferred theoretically because the equilibrium constant is large and the rate for any amount of enzyme is 2-3 times faster, thus smaller sample and shorter observation periods are needed. Disadvantages of the pyruvate-to-lactate reaction are loss of linearity as compared with the lactate-to-pyruvate reaction, and greater substrate inhibition of the enzyme. [Tietz Fourth Edition]
Source: Regenstrief LOINC
Fully-Specified Name
- Component
- Lactate dehydrogenase
- Property
- CCnc
- Time
- Pt
- System
- CSF
- Scale
- Qn
- Method
- Reaction: lactate to pyruvate
Additional Names
- Short Name
- LDH CSF L to P-cCnc
- Display Name
- LDH Lactate to pyruvate reaction (CSF) [Catalytic activity/Vol]
- Consumer Name Alpha
- Lactate Dehydrogenase (LDH), Spinal Fluid
Basic Attributes
- Class
- CHEM
- Type
- Laboratory
- First Released
- Version 2.34
- Last Updated
- Version 2.68
- Order vs. Observation
- Both
Reference Information
Type | Source | Reference |
---|---|---|
Webcontent | Lab Tests Online®Copyright Copyright © 2001-2019 American Association for Clinical Chemistry | Lactate Dehydrogenase (LD) |
Language Variants Get Info
- zh-CNChinese (China)
- 乳酸脱氢酶:
催化浓度: 时间点: 脑脊液: 定量型: 反应: 乳酸至丙酮酸 - nl-NLDutch (Netherlands)
- lactaatdehydrogenase:
enzymatische activiteit/volume: moment: liquor cerebrospinalis: kwantitatief: reactie: lactaat naar pyruvaat - fr-BEFrench (Belgium)
- Lactate déshydrogénase:
Concentration catalytique: Temps ponctuel: LCR: Quantitatif: Réaction: lactate en pyruvate - fr-CAFrench (Canada)
- Lactate déshydrogénase:
Concentration catalytique: Temps ponctuel: LCR: Quantitatif: Réaction: lactate en pyruvate - fr-FRFrench (France)
- Lactate déhydrogénase:
Catalytique/Volume: Ponctuel: Liquide céphalorachidien: Numérique: Réaction : Lactate vers Pyruvate - de-DEGerman (Germany)
- Lactatdehydrogenase:
KKnz: Pkt: CSF: Qn: Reaktion: Lactat zu Pyruvat - it-ITItalian (Italy)
- Lattato deidrogenasi:
CCnC: Pt: LCS: Qn: Reazione: lattato in piruvato - pt-BRPortuguese (Brazil)
- Lactato dehidrogenase:
: Pt: LCR: Qn: Reação: lactato e Piruvato - es-ESSpanish (Spain)
- Lactato deshidrogenasa:
Concentración Catalítica: Punto temporal: Líquido Cefalorraquideo: Qn: Reacción - lactato piruvato - tr-TRTurkish (Turkey)
- Laktat dehidrojenaz:
KtlKons: Zmlı: BOS: Kant: Reaksiyon: laktat tan piruvat a
Example Units
Unit | Source |
---|---|
U/L | Example UCUM Units |
U/L | Original Submission |
LOINC FHIR® API Example - CodeSystem Request Get Info
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=60024-7
LOINC Copyright
Copyright © 2020 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright