Version 2.70

62875-0PhenX - assay for human leukocyte antigen (HLA) genotyping protocol 160601Trial

Status Information


Term Description

This protocol includes instructions for drawing, processing and storing blood according to the Type 1 Diabetes Genetics Consortium (T1DGC) Manual of Operations. Human Leukocyte Antigen is measured by using the linear array genotyping system method. The PhenX Infectious Diseases and Immunity Working Group would like to note that the science of HLA matching is rapidly advancing and evolving and multiple methods for HLA assays are available. To aid in comparability, the Infectious Diseases and Immunity Working Group recommends that the investigator record the make and manufacturer of equipment used and the repeatability and coefficients of variation for the assay. Please also note that the immobilized linear arrays used to genotype the samples were provided by Roche Molecular Systems and are not commercially available.
Source: Regenstrief LOINC

Part Description

LP20670-3   Leukocyte
Leukocytes or white blood cells (WBCs) are immune cells that fight infection, neoplasms and other inflammatory conditions, and mediate allergic responses. There are five types of WBCs normally present in the circulation that are all derived from a similar stem cell in the bone marrow. The five type of WBCs are divided into two groups based on the presence or absence of granules in the cytoplasm. The granulocytes include the neutrophils, basophils and eosinophils. The non-granulocytes include the lymphocytes and the monocytes. The neutrophils fight infection by ingesting and digesting bacteria. Eosinophils and basophils respond to allergic reactions and are capable of ingesting antigen-antibody complexes. Monocytes phagocytose bacteria and release interferon to stimulate the immune system. Lymphocytes are divided into T-cells and B-cells. T-cell immunity is cellular and involves the activation of phagocytes and B-cell immunity uses antibodies to fight infection. Both elevated and low leukocyte counts can be markers of infection and malignancy, and low leukocyte counts are associated with a variety of primary and secondary immunodeficiencies, depending on the WBC type(s) that are out of range. (Mosby's manual of diagnostic and laboratory tests, Kathleen Deska Pagana; Timothy James Pagana, Elsevier St. Louis, Mo ©2010) Source: Regenstrief LOINC

Panel Hierarchy
Details for each LOINC in Panel LHC-Forms

LOINC Name R/O/C Cardinality Example UCUM Units
62875-0 PhenX - assay for human leukocyte antigen (HLA) genotyping protocol 160601
Indent51953-8 Collection date of Blood
Indent69866-2 Process variables for assays - human leukocyte antigen - HLA PhenX
IndentIndent66180-1 Was blood drawn?
IndentIndent66181-9 Was full sample obtained?
IndentIndent8251-1 Service comment
IndentIndent8251-1 Service comment
IndentIndent66200-7 Repeatability of the assay {ratio}
IndentIndent66201-5 Coefficient of variation for the assay {CV}
Indent69864-7 Manufacturer variables for assays PhenX
IndentIndent66208-0 Make of the equipment used to perform...
IndentIndent74719-6 Manufacturer of the equipment used

Fully-Specified Name

PhenX - assay for human leukocyte antigen (HLA) genotyping protocol 160601

Additional Names

Short Name
Assay human leukocyte antg (HLA) proto

Survey Question


Basic Attributes

First Released
Version 2.36
Last Updated
Version 2.67
Change Reason
Updated the PhenX ID from "PhenX.<ID>" to "PX<ID>" in Survey Question Source field to align with the variable identifier used in the PhenX Toolkit.; Added the PhenX protocol ID to the Component to clearly define the protocol version for which this panel is based upon.
Panel Type

Reference Information

Type Source Reference
Citation Consensus measures for Phenotypes and Exposures NIH. NIDDK. Type 1 Diabetes Genetics Consortium Manual Of Operations. Blood Collection and Processing.
Citation Consensus measures for Phenotypes and Exposures Silke Rosinger, Sarah Nutland, Eric Mickelson, Michael D Varney, Bernard O Boehm, Gary J Olsem, John A Hansen, Ian Nicholson, Joan E Hilner, Letitia H Perdue, June J Pierce, Beena Akolkar, Concepcion Nierras, Michael W Steffes and T1DGC. Collection and processing of whole blood for transformation of peripheral blood mononuclear cells and extraction of DNA: the Type 1 Diabetes Genetics Consortium. Clinical Trials. 2010; 7: S65-S74.
Citation Consensus measures for Phenotypes and Exposures Josyf C Mychaleckyj, Janelle A Noble, Priscilla V Moonsamy, Joyce A Carlson, Michael D Varner, Jeff Post, Wolfgang Helmberg, June J Pierce, Persia Bonella, Anna Lisa Fear, Eva Lavant, Anthony Louey, Sean Boyle, Julie A Lane, Paul Sali, Samuel Kim, Rebecca Rappner, Dustin T Williams, Letitia H Perdue, David M Reboussin, Brian D Tait, Beena Akolkar, Joan E Hilner, Michael W Steffes, Henry A Erlich and T1DGC. HLA genotyping in the international Type 1 Diabetes Genetics Consortium. Clinical Trials. 2010; 7: S75-S87.

Member of these Panels

LOINC Long Common Name
62863-6 PhenX domain - Infectious diseases and immunity

Language Variants Get Info

zh-CNChinese (China)
PhenX - 人类白细胞抗原基因分型方案 160601:-:时间点:^患者:-:PhenX
it-ITItalian (Italy)
PhenX - esame per antigene leucocitario umano ( HLA ) genotipizzazione, protocollo:-:Pt:^Paziente:-:PhenX
ru-RURussian (Russian Federation)
PhenX - анализ на человеческий лейкоцитарный антиген (HLA) генотипирование протокол:-:ТчкВрм:^Пациент:-:PhenX

LOINC FHIR® API Example - CodeSystem Request Get Info