63244-8
Ganglioside GM1 IgG+IgM Ab [Presence] in Serum by Immunoassay
Active
Part Descriptions
LP36423-9 Ganglioside GM1
Gangliosides are a family of molecules that are present throughout the body but especially prevalent in cells of the nervous system. Specific gangliosides are named for the carbohydrate sequence they contain and have a unique distribution within the nervous system. The oligosaccharide groups on gangliosides act as cell surface markers that play a role in cellular recognition and cell-to-cell communication, and they also act as specific receptors for certain pituitary glycoprotein hormones and certain bacterial protein toxins such as cholera toxin.
Anti-ganglioside antibodies, primarily IgG, are present in the sera from approximately 60% of patients with Guillain-Barré syndrome (GBS), and antibodies against different gangliosides are associated with different forms of GBS.
1. Antibodies against GD1a/GD1b and GD1b/GT1b complexes have been found in patients with more severe GBS requiring mechanical ventilation;
2. Antibodies against GM1 or those against GalNAc-GD1a have been associated with acute motor axonal neuropathy;
3. Anti-GQ1b antibodies are specifically associated with a variant of GBS called Fisher syndrome, which is characterized by ophthalmoplegia and ataxia.
Detection of specific markers early in the course of GBS may help guide the plan of care. PMID: 21214559
Source: Regenstrief LOINC, PMID: 2121455
LP222219-0 Ganglioside
A ganglioside molecule consists of a glycosphingolipid (ceramide and oligosaccharide) with one or more sialic acid residues linked to the sugar chain. Molecules with one sialic acid residue are called monosialogangliosides (GM), those with two are called disialogangliosides (GD), and those with three are trisialogangliosides (GT). Gangliosides without any sialic acid residues are called asialogangliosides, while those that do not have a ceramide N-acyl group are called lysogangliosides. The number that typically is included at the end of the name indicates the order in which the molecule was discovered. For example, GM2 is a ganglioside with one sialic acid residue that was the second GM to be identified.
Source: Regenstrief LOINC
Fully-Specified Name
- Component
- Ganglioside GM1 Ab.IgG+IgM
- Property
- PrThr
- Time
- Pt
- System
- Ser
- Scale
- Ord
- Method
- IA
Additional Names
- Short Name
- GM1 Gangl IgG+IgM Ser Ql IA
- Display Name
- Ganglioside GM1 IgG+IgM IA Ql (S)
- Consumer Name Alpha Get Info
- Ganglioside GM1 IgG+IgM, Blood
Basic Attributes
- Class
- SERO
- Type
- Laboratory
- First Released
- Version 2.36
- Last Updated
- Version 2.73
- Change Reason
- The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.; The EIA method, which was always intended to cover more than just enzyme-linked immunoassay and whose display name for the long common name has always been Immunoassay, was renamed IA in order to eliminate ambiguity about whether the method has a broader meaning than just enzyme-linked immunoassay. Likewise, EIA.rapid was renamed IA.rapid. These changes were approved by the Laboratory LOINC Committee in June 2016.
- Order vs. Observation
- Both
- Common Test Rank Get Info
- 13521
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 82455-7 | Ganglioside Ab panel - Serum |
Member of these Groups Get Info
| LOINC Group | Group Name |
|---|---|
| LG12484-8 | Ganglioside GM1 Ab.IgG+IgM| |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| es-ES | Spanish (Spain) | Gangliósido GM1 IgG+IgM: |
| es-MX | Spanish (Mexico) | Gangliósido GM1 Ab.IgG + IgM: |
| et-EE | Estonian (Estonia) | Gangliosiid GM1 antikehad.IgG+IgM: Synonyms: Immuunglobuliin G Immuunglobuliin M Järgarvuline Juhuslik Seerum |
| fr-CA | French (Canada) | Ganglioside GM1, IgG+IgM: |
| fr-FR | French (France) | Ganglioside GM1 anticorps IgG+IgM: |
| fr-BE | French (Belgium) | Ganglioside GM1 Anticorps.IgG+IgM: Synonyms: Anticorps |
| it-IT | Italian (Italy) | Ganglioside GM1 Ab.IgG+IgM: Synonyms: anticorpi IgG anticorpi IgG e IgM Anticorpi IgG+IgM anticorpo Immunoassay Presenza o Soglia Punto nel tempo (episodio) Siero Sierologia (anticorpi e la maggior parte degli ant |
| nl-NL | Dutch (Netherlands) | ganglioside GM1 As.IgG + IgM: Synonyms: antistof; |
| ru-RU | Russian (Russian Federation) | Ганглиозид GM1 Ат.IgG+IgM: Synonyms: Антитело Порядковый Сыворотка Точка во времени; |
| tr-TR | Turkish (Turkey) | Gangliozid GM1 Ab.IgG+IgM: Synonyms: Ak Ak.IgG Ak.IgG+IgM İmmünölçüm, immünoassay Mevcut |
| uk-UA | Ukrainian (Ukraine) | Гангліозид GM1 Антитіла.IgG+IgM: Synonyms: ABS; |
| zh-CN | Chinese (China) | 神经节苷脂 GM1 抗体.IgG+IgM: Synonyms: Ab.IgG; |
LOINC Terminology Service (API) using HL7® FHIR® Get Info
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- CodeSystem lookup
- https:
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LOINC Copyright
Copyright © 2024 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright