64083-9
MGMT gene methylation score in Tissue by Molecular genetics method
Active
Part Descriptions
LP115710-8 MGMT gene methylation score
O(6)-methylguanine-DNA methyltransferase (MGMT) is an essential enzyme involved in the repair of damage caused by a variety of DNA crosslinking compounds, including alkylating agents. Hypermethylation of the MGMT gene promoter region causes diminished or silenced expression of the gene, making cells more sensitive to DNA damage and prone to tumor development. Approximately 40% to 45% of glioblastoma multiforme (GBM) tumors exhibit MGMT gene methylation. In patients with malignant brain tumors, the loss of activity has been shown to be a promising predictor of response to alkylating agent-based chemotherapies, including BCNU (carmustine), CCNU and Temozolomide. The loss of MGMT activity in tumor cells can no longer repair the methyl adduct formation caused by the chemotherapy, leading to lethal cross-links between DNA strands. Most patients with methylated MGMT (m_MGMT) experience an increase in overall survival and time to progression of the disease.
The MGMT and ß-Actin copy numbers will be used to calculate the ratio (score) of MGMT/ß-Actin x 1000.
<2 methylation not detected
≥2 and < 8 low level methylation
≥8 methylation detected
Source: LOINC partner 1
LP124510-1 gene methylation
DNA methylation is essential during embryonic development, and patterns of DNA methylation are generally transmitted to daughter cells with a high fidelity. In cancer, aberrant DNA methylation patterns are found in two distinct forms: hypermethylation and hypomethylation. Hypermethylation is one of the major epigenetic modifications that repress transcription via the promoter region of tumor suppressor genes. Hypermethylation typically occurs at CpG islands in the promoter region and is associated with gene inactivation. Hypomethylation, linked to chromosomal instability and loss of imprinting, arises earlier and occurs throughout the progression of cancer.
More specifically, methylated DNA can bind to methyl-CpG-binding domain proteins (MBDs), which recruit additional proteins such as histone deacetylases and other chromatin remodeling proteins that modify histones to form compact, inactive chromatin, termed silent chromatin. Loss of methyl-CpG-binding protein 2 (MeCP2) has been implicated in Rett syndrome; and methyl-CpG-binding domain protein 2 (MBD2) mediates the transcriptional silencing of hypermethylated genes in cancer. Research has suggested that long-term memory storage in humans may be regulated by DNA methylation.
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Source: Wikipedia, Wikipedia
Fully-Specified Name
- Component
- MGMT gene methylation score
- Property
- Ratio
- Time
- Pt
- System
- Tiss
- Scale
- Qn
- Method
- Molgen
Additional Names
- Short Name
- MGMT methylation score Tiss
- Display Name
- MGMT gene methylation score Molgen (Tiss) [Ratio]
- Consumer Name Alpha Get Info
- MGMT gene methylation score, Tissue
Basic Attributes
- Class
- MOLPATH
- Type
- Laboratory
- First Released
- Version 2.36
- Last Updated
- Version 2.73
- Order vs. Observation
- Observation
- Common Test Rank Get Info
- 13368
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| es-ES | Spanish (Spain) | Marcador del gen de metilación MGMT: Synonyms: Cuantitativo |
| es-MX | Spanish (Mexico) | Puntuación de metilación del gen MGMT: |
| fr-FR | French (France) | MGMT gène méthylation score: |
| it-IT | Italian (Italy) | MGMT, punteggio di metilazione gene: Synonyms: Genetica molecolare Metilazione del gene MGMT Patologia molecolare Punteggio di metilazione gene MGMT Punto nel tempo (episodio) Tessuto & |
| nl-NL | Dutch (Netherlands) | MGMT genmethylatie score: Synonyms: molgen |
| ru-RU | Russian (Russian Federation) | MGMT ген метилирования число: Synonyms: Итог Количественный Коэффициент; |
| tr-TR | Turkish (Turkey) | MGMT geni metilasyon skoru: |
| zh-CN | Chinese (China) | MGMT 基因甲基化评分: Synonyms: MGMT 基因甲基化评分（分值、 |
LOINC Terminology Service (API) using HL7® FHIR® Get Info
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- CodeSystem lookup
- https:
//fhir.loinc.org/CodeSystem/$lookup?system=http: //loinc.org&code=64083-9
LOINC Copyright
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