Version 2.77

Part Description

LP39188-5   Aquaporin 4 water channel Ab.IgG
The water channel aquaporin 4 (AQP4) receptor regulates the water homeostasis in the central nervous system (CNS). Autoantibodies to the AQP4 receptor bind to the receptor and cause neuromyelitis optica (NMO) which is an idiopathic, severe, demyelinating disease of the CNS that primarily affects the optic nerve and spinal cord. Before the discovery of the AQP4 receptor antibody NMO was often misdiagnosed as a variant of multiple sclerosis (MS). With improved clinical laboratory tests and distinct immunological and pathological attributes the two diseases are less often confused. Distinguishing MS and NMO is especially important because they have different treatments. Treatment for NMO includes corticosteroids and plasmapheresis; typical medications used to treat MS, such as beta-interferon and glatiramer acetate are not effective against NMO. During the disease process, the aquaporin 4 receptor antibody binds to the aquaporin 4 receptor initiating the activation of complement, inflammatory demyelination and necrosis. Eighty to ninety percent of patients with NMO experience recurrent episodes of optic neuritis and myelitis. Many patients with NMO also have other autoimmune diseases including thyroiditis, systemic lupus erythematosus
and Sjogren's syndrome. PMID: 17706564 Detection of APQ4-IgG is indicative of a relapsing disease. Immediate treatment with immunosuppressive drugs reduces the frequency and disability of future attacks. [http://labmed.ucsf.edu/labmanual/db/dataall/tests/1424.html] Source: Regenstrief LOINC

Fully-Specified Name

Component
Aquaporin 4 water channel Ab.IgG
Property
ACnc
Time
Pt
System
Ser/Plas
Scale
Qn
Method
IA

Additional Names

Short Name
AQP4 H2O channel IgG SerPl IA-aCnc
Display Name
Aquaporin 4 water channel IgG IA Qn
Consumer Name Alpha Get Info
Aquaporin 4 water channel IgG antibody, Blood

Basic Attributes

Class
SERO
Type
Laboratory
First Released
Version 2.38
Last Updated
Version 2.73
Change Reason
Release 2.67: COMPONENT: Updated "receptor" to "water channel" per current scientific nomenclature; Previous Releases: The EIA method, which was always intended to cover more than just enzyme-linked immunoassay and whose display name for the long common name has always been Immunoassay, was renamed IA in order to eliminate ambiguity about whether the method has a broader meaning than just enzyme-linked immunoassay. Likewise, EIA.rapid was renamed IA.rapid. These changes were approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation
Both
Common Test Rank Get Info
11991

Member of these Groups Get Info

LOINC Group Group Name
LG17454-6 Aquaporin 4 water channel Ab.IgG|ACnc|Pt|ANYBldSerPl

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) Receptor de Acuaporina 4 IgG:Concentración arbitraria:Punto temporal:Suero o Plasma:Qn:IA
Synonyms: Cuantitativo
es-MX Spanish (Mexico) Acuaporina 4 canal de agua Ab.IgG:Concentración arbitraria:Punto temporal:Suero o Plasma:Cuantitativo:Inmunoensayo
et-EE Estonian (Estonia) Akvaporiin 4 retseptor antikehad.IgG:Acnc:Pt:S/P:Qn:IA
Synonyms: Immuunglobuliin G Juhuslik Kvantitatiivne Plasma Seerum Seerum või plasma
fr-CA French (Canada) Récepteur Aquaporin 4 , IgG:Concentration arbitraire:Temps ponctuel:Sérum/Plasma:Quantitatif:IA
fr-FR French (France) Aquaporine 4 récepteur anticorps IgG:Arbitraire/Volume:Ponctuel:Sérum/Plasma:Numérique:Immunoanalyse
fr-BE French (Belgium) Récepteur Aquaporin 4 Anticorps. IgG:Concentration arbitraire:Temps ponctuel:Sérum/Plasma:Quantitatif:IA
Synonyms: Anticorps
it-IT Italian (Italy) Acquaporina 4, canale idrico Ab.IgG:ACnc:Pt:Siero/Plasma:Qn:IA
Synonyms: anticorpi IgG anticorpo Canale idrico dell''acquaporina 4 Concentrazione Arbitraria Immunoassay Plasma Punto nel tempo (episodio) Siero Siero o Plasma Sierologia (anticorpi e la maggior parte degli ant
nl-NL Dutch (Netherlands) aquaporine 4 waterkanaal As.IgG:eenheid/volume:moment:serum of plasma:kwantitatief:immunoassay
Synonyms: antistof; antilichaam IA
ru-RU Russian (Russian Federation) Аквапорина 4 рецепторы Ат.IgG:ПроизвКонц:ТчкВрм:Сыв/Плаз:Колич:IA
Synonyms: Антитело Количественный Плазма Произвольная концентрация Сыворотка Сыворотка или Плазма Точка во времени;Момент
tr-TR Turkish (Turkey) Akuaporin 4 reseptörü Ab.IgG:SçKons:Zmlı:Ser/Plaz:Kant:İA
Synonyms: Ak Ak.IgG İmmünölçüm, immünoassay
uk-UA Ukrainian (Ukraine) Аквапорин-4 водний канал Антитіла. IgG:Довільна Концентрація:МоментЧасу:Сироватка/Плазма:Кількісно:Імуноаналіз
Synonyms: ABS; Aby; Antby; Anti; Antibodies; Antibody; AQP4; AQP4 H2O channel; Arbitrary Concentration; Autoantibodies; Autoantibody; Devic's disease; EIA; ELFA; ELISA; Enzyme immunoassay; IAA; Immune globulin G; Immunoglobulin G; MEIA; Neuromyelitis optica; NMO; NMO spectrum disorders; NMOSD; Opticospinal multiple sclerosis; Pl; Plasma; Plsm; Point in time; QNT; Quan; Quant; Quantitative; Random; Serology; SerP; SerPl; SerPlas; Serum; Serum or plasma; SR; SUDS; Water channel aquaporin-4
zh-CN Chinese (China) 水通道蛋白 4 受体 抗体.IgG:任意型浓度:时间点:血清/血浆:定量型:免疫测定法
Synonyms: Ab.IgG;IgG;抗体 IgG Ab;自身抗体 Devic 氏综合征 IgG Devic 综合征 IgG Devic氏综合征 Ab.IgG Devic氏综合征抗体.IgG Devic综合征 Ab.IgG Devic综合征抗体.IgG H2O NMO Ab.IgG NMO 抗体.IgG 任意型浓度(单位体积);任意浓度;单位体积的任意单位数;人工型浓度 免疫测定;免疫分析法;免疫检定法;免疫检定;免疫试验;酶免疫测定法;酶免疫测定;酶免疫分析法;酶免疫检定法;酶免疫检定;酶免疫试验 免疫球蛋白 G 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 时刻;随机;随意;瞬间 血清;血清学;血清学检验项目;血清学检验项目 (非微生物学);血清学检验项目（非微生物学）;血清学检验项目类;血清学检验项目类 (非微生物学);血清学类;血清学类检验项目;血清学类检验项目 (非微生物学);血清学类试验;血清学类试验 (非微生物学);血清学试验;血清学试验 (非微生物学);血清学试验（非微生物学）;血清学试验类 (非微生物学);血清类 血清或血浆 视神经脊髓炎 Ab.IgG 视神经脊髓炎 IgG

Example Units

Unit Source
units/mL REGENSTRIEF
[arb'U]/mL Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=68548-7