LOINC
Version 2.73

68548-7Aquaporin 4 water channel IgG Ab [Units/volume] in Serum or Plasma by ImmunoassayActive

Part Description

LP39188-5   Aquaporin 4 water channel Ab.IgG
The water channel aquaporin 4 (AQP4) receptor regulates the water homeostasis in the central nervous system (CNS). Autoantibodies to the AQP4 receptor bind to the receptor and cause neuromyelitis optica (NMO) which is an idiopathic, severe, demyelinating disease of the CNS that primarily affects the optic nerve and spinal cord. Before the discovery of the AQP4 receptor antibody NMO was often misdiagnosed as a variant of multiple sclerosis (MS). With improved clinical laboratory tests and distinct immunological and pathological attributes the two diseases are less often confused. Distinguishing MS and NMO is especially important because they have different treatments. Treatment for NMO includes corticosteroids and plasmapheresis; typical medications used to treat MS, such as beta-interferon and glatiramer acetate are not effective against NMO. During the disease process, the aquaporin 4 receptor antibody binds to the aquaporin 4 receptor initiating the activation of complement, inflammatory demyelination and necrosis. Eighty to ninety percent of patients with NMO experience recurrent episodes of optic neuritis and myelitis. Many patients with NMO also have other autoimmune diseases including thyroiditis, systemic lupus erythematosus
and Sjogren's syndrome.[PMID:17706564] Detection of APQ4-IgG is indicative of a relapsing disease. Immediate treatment with immunosuppressive drugs reduces the frequency and disability of future attacks. [http://labmed.ucsf.edu/labmanual/db/dataall/tests/1424.html] Source: Regenstrief LOINC, ARUP

Fully-Specified Name

Component
Aquaporin 4 water channel Ab.IgG
Property
ACnc
Time
Pt
System
Ser/Plas
Scale
Qn
Method
IA

Additional Names

Short Name
AQP4 H2O channel IgG SerPl IA-aCnc
Display Name
Aquaporin 4 water channel IgG IA Qn
Consumer Name Alpha
Aquaporin 4 water channel IgG antibody, Blood

Basic Attributes

Class
SERO
Type
Laboratory
First Released
Version 2.38
Last Updated
Version 2.73
Change Reason
Release 2.67: COMPONENT: Updated "receptor" to "water channel" per current scientific nomenclature; Previous Releases: The EIA method, which was always intended to cover more than just enzyme-linked immunoassay and whose display name for the long common name has always been Immunoassay, was renamed IA in order to eliminate ambiguity about whether the method has a broader meaning than just enzyme-linked immunoassay. Likewise, EIA.rapid was renamed IA.rapid. These changes were approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation
Both
Common US Lab Results Rank
11991

Member of these Groups

LG17454-6 Aquaporin 4 water channel Ab.IgG|ACnc|Pt|ANYBldSerPl

Language Variants Get Info

zh-CNChinese (China)
水通道蛋白 4 受体 抗体.IgG:任意型浓度:时间点:血清/血浆:定量型:免疫测定法
nl-NLDutch (Netherlands)
aquaporine 4 waterkanaal As.IgG:eenheid/volume:moment:serum of plasma:kwantitatief:immunoassay
et-EEEstonian (Estonia)
Akvaporiin 4 retseptor antikehad.IgG:Acnc:Pt:S/P:Qn:IA
fr-BEFrench (Belgium)
Récepteur Aquaporin 4 Anticorps. IgG:Concentration arbitraire:Temps ponctuel:Sérum/Plasma:Quantitatif:IA
fr-CAFrench (Canada)
Récepteur Aquaporin 4 , IgG:Concentration arbitraire:Temps ponctuel:Sérum/Plasma:Quantitatif:IA
fr-FRFrench (France)
Aquaporine 4 récepteur anticorps IgG:Arbitraire/Volume:Ponctuel:Sérum/Plasma:Numérique:Immunoanalyse
it-ITItalian (Italy)
Acquaporina 4, canale idrico Ab.IgG:ACnc:Pt:Siero/Plasma:Qn:IA
ru-RURussian (Russian Federation)
Аквапорина 4 рецепторы Ат.IgG:ПроизвКонц:ТчкВрм:Сыв/Плаз:Колич:IA
es-MXSpanish (Mexico)
Acuaporina 4 canal de agua Ab.IgG:Concentración arbitraria:Punto temporal:Suero o Plasma:Cuantitativo:Inmunoensayo
es-ESSpanish (Spain)
Receptor de Acuaporina 4 IgG:Concentración arbitraria:Punto temporal:Suero o Plasma:Qn:IA
tr-TRTurkish (Turkey)
Akuaporin 4 reseptörü Ab.IgG:SçKons:Zmlı:Ser/Plaz:Kant:İA

Example Units

Unit Source
[arb'U]/mL Example UCUM Units
units/mL REGENSTRIEF

LOINC FHIR® API Example - CodeSystem Request Get Info

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=68548-7