6896-5
cloZAPine [Mass/volume] in Serum or Plasma
Active
Term Description
Per ARUP, clozapine levels are used to evaluate toxicity and monitor therapeutic drug levels. 100 ng/mL is the minimum therapeutic threshold, and levels > 1200 ng/mL increase the likelihood of adverse effects such as seizures.
Source: Regenstrief LOINC
Part Descriptions
LP17236-8 cloZAPine
Clozapine (sold as Clozaril ®, Leponex ®, Fazaclo ®) was the first of the atypical antipsychotics to be developed. It was approved by the United States Food and Drug Administration (FDA) in 1989 and is the only FDA-approved medication indicated for treatment-resistant schizophrenia and for reducing the risk of suicidal behaviour in patients with schizophrenia.
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Source: Wikipedia, Clozapine (Wikipedia)
LP17236-8 cloZAPine
A tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. Agranulocytosis is a major adverse effect associated with administration of this agent.
Source: National Library of Medicine, MeSH 2006
Fully-Specified Name
- Component
- cloZAPine
- Property
- MCnc
- Time
- Pt
- System
- Ser/Plas
- Scale
- Qn
- Method
Additional Names
- Short Name
- cloZAPine SerPl-mCnc
- Display Name
- cloZAPine [Mass/Vol]
- Consumer Name Alpha Get Info
- cloZAPine, Blood
Basic Attributes
- Class
- DRUG/TOX
- Type
- Laboratory
- First Released
- Version 1.0h(2)
- Last Updated
- Version 2.73
- Order vs. Observation
- Both
- Common Test Rank Get Info
- 2327
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 65632-2 | cloZAPine and Norclozapine panel - Serum or Plasma |
Member of these Groups Get Info
| LOINC Group | Group Name |
|---|---|
| LG48379-8 | Clozapine| |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| de-DE | German (Germany) | Clozapin: |
| de-AT | German (Austria) | Synonyms: Clozapin |
| es-AR | Spanish (Argentina) | clozapina: |
| es-MX | Spanish (Mexico) | clozapina: |
| es-ES | Spanish (Spain) | Clozapina: Synonyms: Cuantitativo |
| et-EE | Estonian (Estonia) | Klosapiin: Synonyms: Juhuslik Kvantitatiivne Plasma Seerum Seerum või plasma |
| fr-FR | French (France) | Clozapine: |
| fr-BE | French (Belgium) | Clozapine: |
| fr-CA | French (Canada) | Clozapine: Synonyms: #REF! |
| it-IT | Italian (Italy) | Clozapina: Synonyms: Concentrazione di Massa Livelli farmacologici e tossicologia Plasma Punto nel tempo (episodio) Siero Siero o Plasma |
| ko-KR | Korean (Korea, Republic Of) | 클로자핀: |
| nl-NL | Dutch (Netherlands) | clozapine: |
| pt-BR | Portuguese (Brazil) | Clozapina: Synonyms: Clozaril; |
| ru-RU | Russian (Russian Federation) | Клозапин: Synonyms: Количественный Массовая концентрация Плазма Сыворотка Сыворотка или Плазма Точка во времени; |
| tr-TR | Turkish (Turkey) | Klozapine: |
| uk-UA | Ukrainian (Ukraine) | клозапін: Synonyms: Clozaril; |
| zh-CN | Chinese (China) | 氯氮平: Synonyms: 可用数量表示的; |
Example Units
| Unit | Source |
|---|---|
| ng/mL | Example UCUM Units |
| ng/mL | REGENSTRIEF |
| ug/L | eCHN |
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