Version 2.80

Term Description

Per ARUP, clozapine levels are used to evaluate toxicity and monitor therapeutic drug levels. 100 ng/mL is the minimum therapeutic threshold, and levels > 1200 ng/mL increase the likelihood of adverse effects such as seizures.

Part Descriptions

LP17236-8   cloZAPine
Clozapine (sold as Clozaril ®, Leponex ®, Fazaclo ®) was the first of the atypical antipsychotics to be developed. It was approved by the United States Food and Drug Administration (FDA) in 1989 and is the only FDA-approved medication indicated for treatment-resistant schizophrenia and for reducing the risk of suicidal behaviour in patients with schizophrenia. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia , Clozapine (Wikipedia)

LP17236-8   cloZAPine
A tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. Agranulocytosis is a major adverse effect associated with administration of this agent. Source: National Library of Medicine, MeSH 2006

Fully-Specified Name

Component
cloZAPine
Property
MCnc
Time
Pt
System
Ser/Plas
Scale
Qn
Method

Additional Names

Long Common Name
cloZAPine [Mass/volume] in Serum or Plasma
Short Name
cloZAPine SerPl-mCnc
Display Name
cloZAPine [Mass/Vol]
Consumer Name Alpha Get Info
cloZAPine, Blood

Basic Attributes

Class
DRUG/TOX
Type
Laboratory
First Released
Version 1.0h(2)
Last Updated
Version 2.73 (MIN)
Order vs. Observation
Both
Common Test Rank Get Info
2327

Member of these Panels

LOINC Long Common Name
65632-2 cloZAPine and Norclozapine panel - Serum or Plasma

Member of these Groups Get Info

LOINC Group Group Name
LG48379-8 Clozapine|Pt|Ser/Plas

Language Variants Get Info

Tag Language Translation
de-DE German (Germany) Clozapin:Massenkonzentration:Zeitpunkt:Serum oder Plasma:Quantitativ:
de-AT German (Austria) Synonyms: Clozapin
el-GR Greek (Greece) Κλοζαπίνη:MCnc:Pt:Ορός/Πλάσμα:Qn:
Synonyms: MCnc Κλοζαπίνη
es-AR Spanish (Argentina) clozapina:concentración de masa:punto en el tiempo:suero/plasma:cuantitativo:
es-MX Spanish (Mexico) clozapina:Concentración de masa:Punto temporal:Suero o Plasma:Cuantitativo:
es-ES Spanish (Spain) Clozapina:Concentración de masa:Punto temporal:Suero o Plasma:Qn:
Synonyms: Cuantitativo
et-EE Estonian (Estonia) Klosapiin:MCnc:Pt:S/P:Qn:
Synonyms: Juhuslik Kvantitatiivne Plasma Seerum Seerum või plasma
fr-FR French (France) Clozapine:Masse/Volume:Ponctuel:Sérum/Plasma:Numérique:
fr-BE French (Belgium) Clozapine:Concentration de masse:Temps ponctuel:Sérum/Plasma:Quantitatif:
fr-CA French (Canada) Clozapine:Concentration de masse:Temps ponctuel:Sérum/Plasma:Quantitatif:
Synonyms: #REF!
it-IT Italian (Italy) Clozapina:MCnc:Pt:Siero/Plasma:Qn:
Synonyms: Concentrazione di Massa Livelli farmacologici e tossicologia Plasma Punto nel tempo (episodio) Siero Siero o Plasma
ko-KR Korean (Korea, Republic Of) 클로자핀:질량농도:검사시점:혈청/혈장:정량:
nl-NL Dutch (Netherlands) clozapine:massa/volume:moment:serum of plasma:kwantitatief:
pt-BR Portuguese (Brazil) Clozapina:MCnc:Pt:Sor/Plas:Qn:
Synonyms: Clozaril; Mass concentration; Level; Point in time; Random; SerPl; SerPlas; SerP; Serum; SR; Plasma; Pl; Plsm; Quantitative; QNT; Quant; Quan; Drugs; DRUG/TOXICOLOGY; DRUG/TOXICOLOGY
ru-RU Russian (Russian Federation) Клозапин:МассКонц:ТчкВрм:Сыв/Плаз:Колич:
Synonyms: Количественный Массовая концентрация Плазма Сыворотка Сыворотка или Плазма Точка во времени;Момент
tr-TR Turkish (Turkey) Klozapine:KütlKons:Zmlı:Ser/Plaz:Kant:
uk-UA Ukrainian (Ukraine) клозапін:Масова Концентрація:МоментЧасу:Сироватка/Плазма:Кількісно:
Synonyms: Clozaril; DRUG/TOXICOLOGY; Drugs; FazaClo; Leponex; Level; Mass concentration; Pl; Plasma; Plsm; Point in time; QNT; Quan; Quant; Quantitative; Random; SerP; SerPl; SerPlas; Serum; Serum or plasma; SR; UniversalLabOrders
zh-CN Chinese (China) 氯氮平:质量浓度:时间点:血清/血浆:定量型:
Synonyms: 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 时刻;随机;随意;瞬间 毒品 毒品类 氯扎平 水平;浓度;质量浓度(单位体积) 药品类 药物 药物/毒理学;药物/毒理学试验;药物毒理学试验;药物毒理学试验类 药物类 血清或血浆

Example Units

Unit Source
ng/mL Example UCUM Units
ng/mL REGENSTRIEF
ug/L eCHN

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=6896-5