Version 2.77

Term Description

Per ARUP, clozapine levels are used to evaluate toxicity and monitor therapeutic drug levels. 100 ng/mL is the minimum therapeutic threshold, and levels > 1200 ng/mL increase the likelihood of adverse effects such as seizures.
Source: Regenstrief LOINC

Part Descriptions

LP17236-8   cloZAPine
Clozapine (sold as Clozaril ®, Leponex ®, Fazaclo ®) was the first of the atypical antipsychotics to be developed. It was approved by the United States Food and Drug Administration (FDA) in 1989 and is the only FDA-approved medication indicated for treatment-resistant schizophrenia and for reducing the risk of suicidal behaviour in patients with schizophrenia. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Clozapine (Wikipedia)

LP17236-8   cloZAPine
A tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. Agranulocytosis is a major adverse effect associated with administration of this agent. Source: National Library of Medicine, MeSH 2006

Fully-Specified Name

Component
cloZAPine
Property
MCnc
Time
Pt
System
Ser/Plas
Scale
Qn
Method

Additional Names

Short Name
cloZAPine SerPl-mCnc
Display Name
cloZAPine [Mass/Vol]
Consumer Name Alpha Get Info
cloZAPine, Blood

Basic Attributes

Class
DRUG/TOX
Type
Laboratory
First Released
Version 1.0h(2)
Last Updated
Version 2.73
Order vs. Observation
Both
Common Test Rank Get Info
2327

Member of these Panels

LOINC Long Common Name
65632-2 cloZAPine and Norclozapine panel - Serum or Plasma

Member of these Groups Get Info

LOINC Group Group Name
LG48379-8 Clozapine|Pt|Ser/Plas

Language Variants Get Info

Tag Language Translation
de-DE German (Germany) Clozapin:Massenkonzentration:Zeitpunkt:Serum oder Plasma:Quantitativ:
de-AT German (Austria) Synonyms: Clozapin
es-AR Spanish (Argentina) clozapina:concentración de masa:punto en el tiempo:suero/plasma:cuantitativo:
es-MX Spanish (Mexico) clozapina:Concentración de masa:Punto temporal:Suero o Plasma:Cuantitativo:
es-ES Spanish (Spain) Clozapina:Concentración de masa:Punto temporal:Suero o Plasma:Qn:
Synonyms: Cuantitativo
et-EE Estonian (Estonia) Klosapiin:MCnc:Pt:S/P:Qn:
Synonyms: Juhuslik Kvantitatiivne Plasma Seerum Seerum või plasma
fr-FR French (France) Clozapine:Masse/Volume:Ponctuel:Sérum/Plasma:Numérique:
fr-BE French (Belgium) Clozapine:Concentration de masse:Temps ponctuel:Sérum/Plasma:Quantitatif:
fr-CA French (Canada) Clozapine:Concentration de masse:Temps ponctuel:Sérum/Plasma:Quantitatif:
it-IT Italian (Italy) Clozapina:MCnc:Pt:Siero/Plasma:Qn:
Synonyms: Concentrazione di Massa Livelli farmacologici e tossicologia Plasma Punto nel tempo (episodio) Siero Siero o Plasma
ko-KR Korean (Korea, Republic Of) 클로자핀:질량농도:검사시점:혈청/혈장:정량:
nl-NL Dutch (Netherlands) clozapine:massa/volume:moment:serum of plasma:kwantitatief:
pt-BR Portuguese (Brazil) Clozapina:MCnc:Pt:Sor/Plas:Qn:
Synonyms: Clozaril; Mass concentration; Level; Point in time; Random; SerPl; SerPlas; SerP; Serum; SR; Plasma; Pl; Plsm; Quantitative; QNT; Quant; Quan; Drugs; DRUG/TOXICOLOGY; DRUG/TOXICOLOGY
ru-RU Russian (Russian Federation) Клозапин:МассКонц:ТчкВрм:Сыв/Плаз:Колич:
Synonyms: Количественный Массовая концентрация Плазма Сыворотка Сыворотка или Плазма Точка во времени;Момент
tr-TR Turkish (Turkey) Klozapine:KütlKons:Zmlı:Ser/Plaz:Kant:
uk-UA Ukrainian (Ukraine) клозапін:Масова Концентрація:МоментЧасу:Сироватка/Плазма:Кількісно:
Synonyms: Clozaril; DRUG/TOXICOLOGY; Drugs; FazaClo; Leponex; Level; Mass concentration; Pl; Plasma; Plsm; Point in time; QNT; Quan; Quant; Quantitative; Random; SerP; SerPl; SerPlas; Serum; Serum or plasma; SR; UniversalLabOrders
zh-CN Chinese (China) 氯氮平:质量浓度:时间点:血清/血浆:定量型:
Synonyms: 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 时刻;随机;随意;瞬间 毒品 毒品类 氯扎平 水平;浓度;质量浓度(单位体积) 药品类 药物 药物/毒理学;药物/毒理学试验;药物毒理学试验;药物毒理学试验类 药物类 血清或血浆

Example Units

Unit Source
ng/mL Example UCUM Units
ng/mL REGENSTRIEF
ug/L eCHN

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=6896-5