69002-4

Human papilloma virus E6+E7 mRNA [Presence] in Cervix by NAA with probe detection

Active

Term Description

This term was created for (but not limited to) Gen-Probe's Aptima HPV assay (Cat No. 302610) that detects the E6 and E7 polycistronic mRNA from 14 high-risk HPV genotypes (16,18,31,33,35,39,45,51,52,56,58,59,66,and 68) that can lead to cervical cancer. E6/E7 genes in high-risk HPV genotypes are known as oncogenes because of their continuous expression, which leads to disruption of cell-cycle check points and cell genome instability through alteration of cellular p53 and retinoblastoma protein functions. This test is similar to LOINC 69358-0, which measures cells containing E6+E7 mRNA via flow cytometry.

Part Description

LP135722-9 Human papilloma virus 16+18+31+33+35+39+45+51+52+56+58+59+66+68 E6+E7 mRNA
Most human papilloma virus (HPV) genomes encode for eight major proteins, six "early" (E1, E2, E3, E4, E6, and E7) and two "late" (L1 and L2). The "early" are regulatory in function. E6 and E7 genes in high-risk HPV genotypes are known as oncogenes because of their continuous expression, which leads to disruption of cell-cycle check points and cell genome instability through alteration of cellular p53 and retinoblastoma protein functions. Source: Regenstrief LOINC

LOINC Names Get Info

Fully-Specified Name: Human papilloma virus 16+18+31+33+35+39+45+51+52+56+58+59+66+68 E6+E7 mRNA:PrThr:Pt:Cvx:Ord:Probe.amp.tar
Long Common Name: Human papilloma virus E6+E7 mRNA [Presence] in Cervix by NAA with probe detection
Short Name: HPV E6+E7 mRNA Cvx Ql NAA+probe
Display Name: HPV E6+E7 mRNA NAA+probe Ql (Cvx)
Consumer Name Alpha Get Info: HPV E6+E7 MRNA, Cervix

Part Model Get Info

Component
Human papilloma virus 16+18+31+33+35+39+45+51+52+56+58+59+66+68 E6+E7 mRNA
LP135722-9
- Analyte
  Human papilloma virus 16+18+31+33+35+39+45+51+52+56+58+59+66+68 E6+E7 mRNA
  LP135722-9
  - Component Numerator
    Human papilloma virus 16+18+31+33+35+39+45+51+52+56+58+59+66+68 E6+E7 mRNA
    LP135722-9
    - Component Numerator Core
      Human papilloma virus 16+18+31+33+35+39+45+51+52+56+58+59+66+68 E6+E7 mRNA
      LP135722-9
    - Component Numerator Core Suffix
      NULL
  - Component Denominator
    NULL
    - Component Denominator Core
      NULL
    - Component Denominator Core Suffix
      NULL
- Challenge
  NULL
- Adjustment
  NULL
- Count
  NULL
Property
PrThr
LP217195-9
Time
Pt
LP6960-1
- Time Core
  Pt
  LP6960-1
- Time Modifier
  NULL
System
Cvx
LP7162-3
- System Core
  Cvx
  LP7162-3
- Super System
  NULL
Scale
Ord
LP7751-3
Method
Probe.amp.tar
LP6464-4

Example Answer List: LL360-9

Source: Regenstrief Institute

Answer	Code	Score	Answer ID
PositiveCopyright http://snomed.info/sct ID:10828004 Positive (qualifier value)			LA6576-8
NegativeCopyright http://snomed.info/sct ID:260385009 Negative (qualifier value)			LA6577-6

Basic Attributes

Class: MICRO
Type: Laboratory
First Released: Version 2.38
Last Updated: Version 2.73 (MIN)
Change Reason: The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation: Both
Common Test Rank Get Info: 1194

Member of these Panels

LOINC	Long Common Name
86636-8	Family planning report - FPAR 2.0 set
72199-3	HEDIS 2013 panel
74234-6	HEDIS 2014 Value Sets
79544-3	HEDIS 2016 Value Sets
82955-6	HEDIS 2017 Value Sets
87625-0	HEDIS 2018 Value Sets
90766-7	HEDIS 2019 Value Sets
94137-7	HEDIS 2020 Value Sets
96068-2	HEDIS MY 2020 Value Sets

Member of these Groups Get Info

LOINC Group	Group Name
LG51639-9	Human papilloma virus 16+18+31+33+35+39+45+51+52+56+58+59+66+68 E6+E7 mRNA\|PrThr\|Sys:ANYGU

Language Variants Get Info

Tag	Language	Translation
cs-CZ	Czech (Czechia)	Lidský papillomavirus E6+E7 mRNA:Přítomnost nebo práh:Časový bod:Děložní hrdlo:Ordinální:Amplifikace nukleových kyselin s detekcí sondou
el-GR	Greek (Greece)	Ιός ανθρωπίνων θηλωμάτων 16+18+31+33+35+39+45+51+52+56+58+59+66+68 E6+E7 mRNA:PrThr:Pt:Cvx:Ord:Ανιχνευτής.ενίσχυση.στόχου Synonyms: Cvx MICRO Ord PrThr Pt Ανιχνευτής Ανιχνευτής.ενίσχυση Ανιχνευτής.ενίσχυση.στόχου Ιός Ιός ανθρώπινων θηλωμάτων Ιός ανθρώπινων θηλωμάτων 16 Ιός ανθρώπινων θηλωμάτων 16 & 18 Ιός ανθρωπίνων θηλωμάτων 16 & 18 & 31+33+35+39+45+51+52+56+58+59+66+68 Ιός ανθρώπινων θηλωμάτων 16+18 Ιός ανθρωπίνων θηλωμάτων 16+18+31+33+35+39+45+51+52+56+58+59+66+68 Ιός ανθρωπίνων θηλωμάτων 16+18+31+33+35+39+45+51+52+56+58+59+66+68 E6+E7 mRNA
es-ES	Spanish (Spain)	ARN m de Papilomavirus humano 16+18+31+33+35+39+45+51+52+56+58+59+66+68 E6+E7:PrThr:Punto temporal:Cuello uterino:Ord:Sonda con amplificación dirigida
es-MX	Spanish (Mexico)	Virus del papiloma humano 16 + 18 + 31 + 33 + 35 + 39 + 45 + 51 + 52 + 56 + 58 + 59 + 66 + 68 ARNm de E6 + E7:Presencia o umbral:Punto temporal:Cuello uterino:Ordinal:Amplificación de ácidos nucleicos con detección de sonda
fr-FR	French (France)	Papillomavirus humain 16+18+31+33+35+39+45+51+52+56+58+59+66+68 E6+E7 ARNm:Présence/Seuil:Ponctuel:Col de l'utérus:Qualitatif:PCR amplification de cible
it-IT	Italian (Italy)	Papilloma virus umano 16+18+31+33+35+39+45+51+52+56+58+59+66+68 E6+E7 mRNA:PrThr:Pt:Cvx:Ord:Sonda.amp.tar Synonyms: Cervice uterina HPV 16+18+31+33+35+39+45+51+52+56+58+59+66+68 Microbiologia mRNA di E6+E7 papilloma virus umano Papilloma virus umano 16 e 18 Presenza o Soglia Punto nel tempo (episodio) Sonda con amplificazione Sonda con amplificazione del target Sonda di DNA
nl-NL	Dutch (Netherlands)	Humaan papillomavirus 16+18+31+33+35+39+45+51+52+56+58+59+66+68 E6+E7 mRNA:aanwezigheid:moment:cervix:ordinaal:probe-detectie Synonyms: baarmoederhals probe.amp.tar
pl-PL	Polish (Poland)	Wirus brodawczaka ludzkiego 16+18+31+33+35+39+45+51+52+56+58+59+66+68 E6+E7 mRNA:granica wykrywalności:punkt w czasie:szyjka macicy:uporządkowany:sonda.amplifikacja.cel Synonyms: amplifikacja kwasu nukleinowego z detekcją za pomocą sondy amplifikacja z detekcją za pomocą sondy HPV HPV 16 HPV 16 i 18 HPV 16 i 18 i 31+33+35+39+45+51+52+56+58+59+66+68 HPV 16+18 HPV 16+18+31+33+35+39+45+51+52+56+58+59+66+68 HPV 16+18+31+33+35+39+45+51+52+56+58+59+66+68 E6+E7 HPV 16+18+31+33+35+39+45+51+52+56+58+59+66+68 E6+E7 mRNA
ru-RU	Russian (Russian Federation)	Вирус папилломы человека 16+18+31+33+35+39+45+51+52+56+58+59+66+68 E6+E7 мРНК:PrThr:ТчкВрм:Шейка:Пор:Проба.усил.миш Synonyms: ДНК проба;ДНК зонд Порядковый Проба с мишени усилением Точка во времени;Момент
tr-TR	Turkish (Turkey)	Human papilloma virüsü 16+18+31+33+35+39+45+51+52+56+58+59+66+68 E6+E7 mRNA:MevcEşik:Zmlı:Cvx:Srl:Prob.amf.hdf Synonyms: Mevcut
zh-CN	Chinese (China)	人乳头瘤病毒 16+18+31+33+35+39+45+51+52+56+58+59+66+68 E6+E7 型 mRNA:存在情况或阈值:时间点:子宫颈:序数型:探针法.基因扩增.靶向 Synonyms: HPV 16 & 18 & 31+33+35+39+45+51+52+56+58+59+66+68 HPV 16 & 18;HPV 16 & 18 型;HPV16 & 18;人类乳头瘤病毒 16 & 18 型;高危 HPV;高危型 HPV;高危型人乳头瘤病毒;高危型人类乳头瘤病毒 HPV 16;HPV 16 型;HPV16;人类乳头瘤病毒 16 型;高危 HPV;高危型 HPV;高危型人乳头瘤病毒;高危型人类乳头瘤病毒 HPV 16+18;HPV 16+18 型;HPV16+18;人类乳头瘤病毒 16+18 型;高危 HPV;高危型 HPV;高危型人乳头瘤病毒;高危型人类乳头瘤病毒 HPV 16+18+31+33+35+39+45+51+52+56+58+59+66+68 E6+E7 型 mRNA HPV 16+18+31+33+35+39+45+51+52+56+58+59+66+68 型 HPV;人乳头瘤病毒（Human papilloma virus，HPV）;人类乳头瘤病毒;生殖器疣传染毒;传染毒素;滤过性病原体;病毒类;过滤性病原体依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型借助扩增的探针方法;借助扩增的探针法;探针法.扩增借助靶向扩增的探针方法;借助靶向扩增的探针法;探针法.扩增.靶向存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值）宫颈;生殖道微生物学;微生物学试验;微生物学试验（培养、DNA、抗原及抗体）扩增型扩增性时刻;随机;随意;瞬间经过扩增的脱氧核糖核酸探针

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LOINC Copyright

Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.