69002-4

Human papilloma virus E6+E7 mRNA [Presence] in Cervix by NAA with probe detection

Active

Term Description

This term was created for (but not limited to) Gen-Probe's Aptima HPV assay (Cat No. 302610) that detects the E6 and E7 polycistronic mRNA from 14 high-risk HPV genotypes (16,18,31,33,35,39,45,51,52,56,58,59,66,and 68) that can lead to cervical cancer. E6/E7 genes in high-risk HPV genotypes are known as oncogenes because of their continuous expression, which leads to disruption of cell-cycle check points and cell genome instability through alteration of cellular p53 and retinoblastoma protein functions. This test is similar to LOINC 69358-0, which measures cells containing E6+E7 mRNA via flow cytometry.
Source: Regenstrief LOINC

Part Description

LP135722-9 Human papilloma virus 16+18+31+33+35+39+45+51+52+56+58+59+66+68 E6+E7 mRNA
Most human papilloma virus (HPV) genomes encode for eight major proteins, six "early" (E1, E2, E3, E4, E6, and E7) and two "late" (L1 and L2). The "early" are regulatory in function. E6 and E7 genes in high-risk HPV genotypes are known as oncogenes because of their continuous expression, which leads to disruption of cell-cycle check points and cell genome instability through alteration of cellular p53 and retinoblastoma protein functions. Source: Regenstrief LOINC

Fully-Specified Name

Component: Human papilloma virus 16+18+31+33+35+39+45+51+52+56+58+59+66+68 E6+E7 mRNA
Property: PrThr
Time: Pt
System: Cvx
Scale: Ord
Method: Probe.amp.tar

Additional Names

Short Name: HPV E6+E7 mRNA Cvx Ql NAA+probe
Display Name: HPV E6+E7 mRNA NAA+probe Ql (Cvx)
Consumer Name Alpha Get Info: HPV E6+E7 MRNA, Cervix

Example Answer List: LL360-9

Source: Regenstrief Institute

Answer	Code	Score	Answer ID
PositiveCopyright http://snomed.info/sct ID:10828004 Positive (qualifier value)			LA6576-8
NegativeCopyright http://snomed.info/sct ID:260385009 Negative (qualifier value)			LA6577-6

Basic Attributes

Class: MICRO
Type: Laboratory
First Released: Version 2.38
Last Updated: Version 2.73
Change Reason: The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation: Both
Common Test Rank Get Info: 1194

Member of these Panels

LOINC	Long Common Name
86636-8	Family planning report - FPAR 2.0 set
72199-3	HEDIS 2013 panel
74234-6	HEDIS 2014 Value Sets
79544-3	HEDIS 2016 Value Sets
82955-6	HEDIS 2017 Value Sets
87625-0	HEDIS 2018 Value Sets
90766-7	HEDIS 2019 Value Sets
94137-7	HEDIS 2020 Value Sets
96068-2	HEDIS MY 2020 Value Sets

Member of these Groups Get Info

LOINC Group	Group Name
LG51639-9	Human papilloma virus 16+18+31+33+35+39+45+51+52+56+58+59+66+68 E6+E7 mRNA\|PrThr\|Sys:ANYGU

Language Variants Get Info

Tag	Language	Translation
es-ES	Spanish (Spain)	ARN m de Papilomavirus humano 16+18+31+33+35+39+45+51+52+56+58+59+66+68 E6+E7:PrThr:Punto temporal:Cuello uterino:Ord:Sonda con amplificación dirigida
es-MX	Spanish (Mexico)	Virus del papiloma humano 16 + 18 + 31 + 33 + 35 + 39 + 45 + 51 + 52 + 56 + 58 + 59 + 66 + 68 ARNm de E6 + E7:Presencia o umbral:Punto temporal:Cuello uterino:Ordinal:Amplificación de ácidos nucleicos con detección de sonda
fr-FR	French (France)	Papillomavirus humain 16+18+31+33+35+39+45+51+52+56+58+59+66+68 E6+E7 ARNm:Présence/Seuil:Ponctuel:Col de l'utérus:Qualitatif:PCR amplification de cible
it-IT	Italian (Italy)	Papilloma virus umano 16+18+31+33+35+39+45+51+52+56+58+59+66+68 E6+E7 mRNA:PrThr:Pt:Cvx:Ord:Sonda.amp.tar Synonyms: Cervice uterina HPV 16+18+31+33+35+39+45+51+52+56+58+59+66+68 Microbiologia mRNA di E6+E7 papilloma virus umano Papilloma virus umano 16 e 18 Presenza o Soglia Punto nel tempo (episodio) Sonda con amplificazione Sonda con amplificazione del target Sonda di DNA
nl-NL	Dutch (Netherlands)	Humaan papillomavirus 16+18+31+33+35+39+45+51+52+56+58+59+66+68 E6+E7 mRNA:aanwezigheid:moment:cervix:ordinaal:probe-detectie Synonyms: baarmoederhals probe.amp.tar
ru-RU	Russian (Russian Federation)	Вирус папилломы человека 16+18+31+33+35+39+45+51+52+56+58+59+66+68 E6+E7 мРНК:PrThr:ТчкВрм:Шейка:Пор:Проба.усил.миш Synonyms: ДНК проба;ДНК зонд Порядковый Проба с мишени усилением Точка во времени;Момент
tr-TR	Turkish (Turkey)	Human papilloma virüsü 16+18+31+33+35+39+45+51+52+56+58+59+66+68 E6+E7 mRNA:MevcEşik:Zmlı:Cvx:Srl:Prob.amf.hdf Synonyms: Mevcut
zh-CN	Chinese (China)	人乳头瘤病毒 16+18+31+33+35+39+45+51+52+56+58+59+66+68 E6+E7 型 mRNA:存在情况或阈值:时间点:子宫颈:序数型:探针法.基因扩增.靶向 Synonyms: HPV 16 & 18 & 31+33+35+39+45+51+52+56+58+59+66+68 HPV 16 & 18;HPV 16 & 18 型;HPV16 & 18;人类乳头瘤病毒 16 & 18 型;高危 HPV;高危型 HPV;高危型人乳头瘤病毒;高危型人类乳头瘤病毒 HPV 16;HPV 16 型;HPV16;人类乳头瘤病毒 16 型;高危 HPV;高危型 HPV;高危型人乳头瘤病毒;高危型人类乳头瘤病毒 HPV 16+18;HPV 16+18 型;HPV16+18;人类乳头瘤病毒 16+18 型;高危 HPV;高危型 HPV;高危型人乳头瘤病毒;高危型人类乳头瘤病毒 HPV 16+18+31+33+35+39+45+51+52+56+58+59+66+68 E6+E7 型 mRNA HPV 16+18+31+33+35+39+45+51+52+56+58+59+66+68 型 HPV;人乳头瘤病毒（Human papilloma virus，HPV）;人类乳头瘤病毒;生殖器疣传染毒;传染毒素;滤过性病原体;病毒类;过滤性病原体依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型借助扩增的探针方法;借助扩增的探针法;探针法.扩增借助靶向扩增的探针方法;借助靶向扩增的探针法;探针法.扩增.靶向存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值）宫颈;生殖道微生物学;微生物学试验;微生物学试验（培养、DNA、抗原及抗体）扩增型扩增性时刻;随机;随意;瞬间经过扩增的脱氧核糖核酸探针

LOINC Terminology Service (API) using HL7^® FHIR^® Get Info

CodeSystem lookup: https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=69002-4

Third Party Copyright

This material includes SNOMED Clinical Terms® (SNOMED CT®) which is used by permission of the International Health Terminology Standards Development Organisation (IHTSDO) under license. All rights reserved. SNOMED CT® was originally created by The College of American Pathologists. "SNOMED" and "SNOMED CT" are registered trademarks of the IHTSDO.

This material includes content from the US Edition to SNOMED CT, which is developed and maintained by the U.S. National Library of Medicine and is available to authorized UMLS Metathesaurus Licensees from the UTS Downloads site at https://uts.nlm.nih.gov.

Use of SNOMED CT content is subject to the terms and conditions set forth in the SNOMED CT Affiliate License Agreement. It is the responsibility of those implementing this product to ensure they are appropriately licensed and for more information on the license, including how to register as an Affiliate Licensee, please refer to http://www.snomed.org/snomed-ct/get-snomed-ct or info@snomed.org<mailto:info@snomed.org>. This may incur a fee in SNOMED International non-Member countries.

LOINC Copyright

Copyright © 2024 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © 1995-2024, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.