69380-4

t(9;22)(q34.1;q11)(ABL1,BCR) b2a2+b3a2 fusion transcript/control transcript (International Scale) [# Ratio] in Blood or Tissue by Molecular genetics method

Active

Term Description

The International Scale (IS) was established in 2005 to standardize quantitative BCR-ABL1 measurements across tests and laboratories. (Hughes et al., Blood 2006). The IS is anchored to the baseline BCR-ABL1 expression level from the International Randomized Study of Interferon vs STI571 (IRIS) trial (100% IS) with a major molecular response (MMR) corresponding to 0.1% IS. (Hughes et al., N Engl J Med 2003). The IRIS trial and follow up studies have demonstrated that achieving MMR, or a 3-log reduction in BCR-ABL1 expression from the standardized baseline level, is a key clinical outcome. Percent ratios on the IS are obtained by multiplying the percent ratio (100 x BCR-ABL1/control gene) determined at local labs by a test-specific conversion factor (IS % ratio = local % ratio x conversion factor).
Source: LOINC partner 1

Part Description

LP136109-8 control transcript (International Scale)
The International Scale (IS) was established in 2005 to standardize quantitative BCR-ABL1 measurements across tests and laboratories. (Hughes et al., Blood 2006). The IS is anchored to the baseline BCR-ABL1 expression level from the International Randomized Study of Interferon vs STI571 (IRIS) trial (100% IS) with a major molecular response (MMR) corresponding to 0.1% IS. (Hughes et al., N Engl J Med 2003). The IRIS trial and follow up studies have demonstrated that achieving MMR, or a 3-log reduction in BCR-ABL1 expression from the standardized baseline level, is a key clinical outcome. Percent ratios on the IS are obtained by multiplying the percent ratio (100 x BCR-ABL1/control gene) determined at local labs by a test-specific conversion factor (IS % ratio = local % ratio x conversion factor). Source: LOINC partner 1

Fully-Specified Name

Component: t(9;22)(q34.1;q11)(ABL1,BCR) b2a2+b3a2 fusion transcript/control transcript (International Scale)
Property: NRto
Time: Pt
System: Bld/Tiss
Scale: Qn
Method: Molgen

Additional Names

Long Common Name: t(9;22)(q34.1;q11)(ABL1,BCR) b2a2+b3a2 fusion transcript/control transcript (International Scale) [# Ratio] in Blood or Tissue by Molecular genetics method
Short Name: t(ABL1,BCR)p210/Control (IS) Bld/T
Display Name: t(9;22)(q34.1;q11)(ABL1,BCR) b2a2+b3a2 fusion transcript/control transcript (International Scale) Molgen (Bld/Tiss) [# ratio]
Consumer Name Alpha Get Info: t(9;22)(q34.1;q11)(ABL1,BCR) B2a2+b3a2/control Transcript (International Scale), Blood or tissue specimen

Basic Attributes

Class: MOLPATH.TRNLOC
Type: Laboratory
First Released: Version 2.38
Last Updated: Version 2.73
Change Reason: Release 2.69: PROPERTY: Property updated to be consistent with similar term 55147-3. RelRto was not correct as the ratio is comparing measurements from the same System.; Previous Releases: Updated Component part to harmonize with ISCN guidelines and current LOINC nomenclature.
Order vs. Observation: Both
Common Test Rank Get Info: 5224

Formula (Readable)

IS % ratio = local % ratio x conversion factor where local % ratio = 100 x BCR-ABL1/control gene

Member of these Panels

LOINC	Long Common Name
72104-3	Acute and chronic leukemia fusion transcript per control transcript panel - Blood or Tissue by Molecular genetics method

Language Variants Get Info

Tag	Language	Translation
es-ES	Spanish (Spain)	t(9;22)(q34.1;q11)(ABL1,BCR) b2a2+b3a2 Tránscritos de fusión/transcrito control (escala internacional):Relación de número:Punto temporal:Sangre o tejido:Qn:Genética molecular Synonyms: Cuantitativo
es-MX	Spanish (Mexico)	t (9; 22) (q34.1; q11) (ABL1, BCR) transcripción de fusión b2a2 + b3a2 / transcripción de control (escala internacional):Proporción numérica:Punto temporal:Sangre o tejido:Cuantitativo:Genética molecular
fr-CA	French (Canada)	t(9;22)(q34.1;q11)(ABL1,BCR) b2a2+b3a2 transcrit de fusion/Transcrit de contrôle (échelle internationale):Ratio de numérique:Temps ponctuel:Sang/Tissu:Quantitatif:Molgen
fr-FR	French (France)	t(9;22)(q34.1;q11)(ABL1,BCR) b2a2+b3a2 transcrit de fusion/transcrit de référence (échelle internationale):Nombre/Nombre:Ponctuel:Sang/Tissu:Numérique:Biologie moléculaire
it-IT	Italian (Italy)	t(9;22)(q34.1;q11)(ABL1,BCR) b2a2+b3a2, trascritto di fusione/trascritto di controllo (Scala Internazionale):NRto:Pt:Sangue/Tess:Qn:Molgen Synonyms: Genetica molecolare Patologia molecolare Punto nel tempo (episodio) Rapporto numerico Sangue Sangue o Tessuto Tessuto & Strisci Traslocazione genetica
nl-NL	Dutch (Netherlands)	t(9;22)(q34.1;q11)(ABL1,BCR) b2a2+b3a2 fusietranscript/controle transcript (internationale schaal):aantalsverhouding:moment:bloed of weefsel:kwantitatief:moleculair genetisch onderzoek Synonyms: molgen
ru-RU	Russian (Russian Federation)	t(9;22)(q34.1;q11)(ABL1,BCR) b2a2+b3a2 слияния транскрипт/контроль транскрипция (Международная Шкала):КолОтн:ТчкВрм:Кр/Тк:Колич:МолГен Synonyms: Количественное отношение Количественный Кровь Кровь или Ткань Ткань и мазки Точка во времени;Момент химерная РНК, закодированная слитым геном
tr-TR	Turkish (Turkey)	t(9;22)(q34.1;q11)(ABL1,BCR) b2a2+b3a2 füzyon transkript/kontrol transkripti (Uluslararası Ölçek):SayOr:Zmlı:Kan/Dk:Kant:Molgen
zh-CN	Chinese (China)	t(9;22)(q34.1;q11)(ABL1,BCR) b2a2+b3a2 融合转录物/对照转录物 (国际标尺):计数型比率:时间点:全血/组织:定量型:分子遗传学类实验室方法 Synonyms: ABL CML JTK7 p150 v-abl Abelson murine leukemia viral oncogene homolog 1 v-abl Abelson 小鼠白血病病毒癌基因同源体 1 v-abl Abelson 小鼠白血病病毒肿瘤基因同源体 1 v-abl Abelson 小鼠白血病病毒致癌基因同源体 1 v-abl Abelson 鼠科动物白血病病毒致癌基因同源体 1 v-abl Abelson 鼠科白血病病毒致癌基因同源体 1 全血或组织;血液/组织;血液或组织分子病理学.基因易位;分子病理学.易位;分子病理学试验.基因易位;分子病理学试验.易位;分子病理学试验类.易位;基因易位分子病理学;分子病理学试验分子遗传学;分子遗传学方法;分子遗传学类方法;分子遗传学类检验方法;包括 RFL、PCR 及其他方法在内，用于在分子基础上检测遗传属性的方法的大类;聚合酶链反应;聚合酶链式反应可用数量表示的;定量性;数值型;数量型;连续数值型标尺同一样本内两种不同实体的数量之比;数量型比;数量型比值;数量型比率;数量或计数型比;数量或计数型比值;计数型比;计数型比值;数量或计数型比率对照转录物（转录本、转录产物、转录子、转录）;对照基因转录本;控制转录本;International Scale 慢性粒细胞性白血病慢性粒细胞白血病慢性粒细胞白血病（Chronic myeloid leukemia，CML）慢性髓系白血病断点簇集区断裂点丛集区断裂点簇集区断裂点聚集区断裂点集中区断裂点集中区（Breakpoint cluster region，BCR）时刻;随机;随意;瞬间易位(9;22)(q34.1;q11)(ABL1,BCR) 易位(9;22)(q34.1;q11)(ABL1,BCR) b2a2 易位(9;22)(q34.1;q11)(ABL1,BCR) b2a2+b3a2 未作说明的组织;组织;组织 & 涂片融合转录物（转录本、转录产物、转录子、转录）;融合基因转录本;融合转录血;血液限制性断裂区

Example Units

Unit	Source
%	Example UCUM Units

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