Version 2.80

Part Descriptions

LP16475-3   Interleukin 7
Interleukin 7 (IL7) is a protein[1] that is encoded by the IL7 gene in humans.

IL-7 a hematopoietic growth factor secreted by stromal cells in the red marrow and thymus. It is also produced by keratinocytes, dendritic cells, neurons and endothelial cells, but is not produced by lymphocytes. IL-7 stimulates the differentiation of multipotent (pluripotent) hematopoietic stem cells into lymphoid progenitor cells (as opposed to myeloid progenitor cells where differentiation is stimulated by IL-3). It also stimulates proliferation of all cells in the lymphoid lineage (B cells, T cells and NK cells). It is important for proliferation during certain stages of B-cell maturation, T and NK cell survival, development and homeostasis.

IL-7 is a cytokine important for B and T cell development. This cytokine and the hepatocyte growth factor (HGF) form a heterodimer that functions as a pre-pro-B cell growth-stimulating factor. This cytokine is found to be a cofactor for V(D)J rearrangement of the T cell receptor beta (TCRB) during early T cell development. This cytokine can be produced locally by intestinal epithelial and epithelial goblet cells, and may serve as a regulatory factor for intestinal mucosal lymphocytes. Knockout studies in mice suggested that this cytokine plays an essential role in lymphoid cell survival.

IL-7 receptor knockout mice exhibit thymic atrophy, arrest of T-cell development at the double positive stage, and severe lymphopenia. Administration of IL-7 to mice results in an increase in thymic migrants, increases in B and T cells, and increased recovery of T cells after cyclophosphamide administration or after bone marrow transplantation.

Il-7 promotes hematological malignacies (acute lymphoblastic leukemia, T cell lymphoma). Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia , Wikipedia

LP16475-3   Interleukin 7
The Interleukins belong to the family termed cytokines. They are peptides used by immune and inflammatory cells to communicate and control cell operations. The cytokines have some similar actions to the Growth Factors but Growth Factors regulate proliferation of non-immune cells. Interleukin 7 is a 25,000 molecular weight glycoprotein produced primarily in bone marrow stromal cells. Its primary target cells are B cells. Interleukin 7 supports long term culture of B cells. Interleukin 7 plays an important role in maintenance of a population of pre B lymphocytes although it does not stimulate differention of pre B cells to B cells. Interleukin 7 also activates myeloid cell proliferation and differentiation. Source: Inter Science Institute , Inter Science Institute

LP7238-1   Body fld
The LOINC "Body fld" System represents body fluids other than serum, plasma, blood, urine, and cerebrospinal fluid. When a LOINC term with the System "Body fld" is used, the specific specimen source or body fluid type should be reported elsewhere with the result. Where more specific terms for pleural, peritoneal, synovial fluid, etc. exist, we encourage you to use the more specific terms. In contrast to "Body fld", the System "Asp" in LOINC represents the fluid withdrawn during an aspiration procedure from an abnormal collection of fluid, such as from an abscess or cyst. "Asp" is used for abnormal fluid collections that are aspirated, while "Body fld" is used for named body fluids, such as synovial fluid or peritoneal fluid, that are not inherently pathologic. Source: Regenstrief LOINC

Fully-Specified Name

Component
Interleukin 7
Property
MCnc
Time
Pt
System
Body fld
Scale
Qn
Method

Additional Names

Long Common Name
Interleukin 7 [Mass/volume] in Body fluid
Short Name
Il7 Fld-mCnc
Display Name
Interleukin 7 (Body fld) [Mass/Vol]
Consumer Name Alpha Get Info
Interleukin 7, Body fluid

Basic Attributes

Class
CHEM
Type
Laboratory
First Released
Version 2.40
Last Updated
Version 2.70 (MIN)
Order vs. Observation
Both

Language Variants Get Info

Tag Language Translation
el-GR Greek (Greece) Ιντερλευκίνη 7:MCnc:Pt:Σωματικό υγρό:Qn:
Synonyms: MCnc Ιντερλευκίνη 7
es-ES Spanish (Spain) Interleuquina 7:Concentración de masa:Punto temporal:Fluido corporal:Qn:
Synonyms: Cuantitativo
es-MX Spanish (Mexico) Interleucina 7:Concentración de masa:Punto temporal:Fluído corporal:Cuantitativo:
fr-CA French (Canada) Interleukine 7:Concentration de masse:Temps ponctuel:Liquide biologique:Quantitatif:
fr-FR French (France) Interleukine-7:Masse/Volume:Ponctuel:Liquide biologique:Numérique:
fr-BE French (Belgium) Interleukine 7:Concentration de masse:Temps ponctuel:Liquide biologique:Quantitatif:
Synonyms: Il7
it-IT Italian (Italy) Interleuchina 7:MCnc:Pt:Liquido corporeo:Qn:
Synonyms: Chimica Concentrazione di Massa Liquido corporeo Punto nel tempo (episodio)
nl-NL Dutch (Netherlands) interleukine 7:massa/volume:moment:lichaamsvocht:kwantitatief:
pt-BR Portuguese (Brazil) Interleucina 7::Pt:LiqOrg:Qn:
ru-RU Russian (Russian Federation) Интерлейкин 7:МассКонц:ТчкВрм:Тело ждк:Колич:
Synonyms: Количественный Массовая концентрация Тела жидкость Точка во времени;Момент
tr-TR Turkish (Turkey) İnterlökin 7:KütlKons:Zmlı:Vücut sv:Kant:
zh-CN Chinese (China) 白细胞介素 7:质量浓度:时间点:体液:定量型:
Synonyms: I L7;Il7;IL-7;Lymphopoietin-1;促淋巴细胞生成素-1;白介素 7;白介素-7;白细胞介素-7 IL 化学;化学检验项目;化学检验项目类;化学类;化学试验;非刺激耐受型化学检验项目;非刺激耐受型化学检验项目类;非刺激耐受型化学试验;非刺激耐受型化学试验类 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 时刻;随机;随意;瞬间 水平;浓度;质量浓度(单位体积) 物体 白介 白介素 白细胞介素（Interleukin，白介素，IL）

Example Units

Unit Source
pg/mL Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=70088-0