70251-4

Pyruvate dehydrogenase IgG Ab [Units/volume] in Serum by Immunoassay

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Part Description

LP18605-3 Pyruvate dehydrogenase
Pyruvate dehydrogenase (E1) is the first component enzyme of pyruvate dehydrogenase complex (PDC). The pyruvate dehydrogenase complex contributes to transforming pyruvate into acetyl-CoA by a process called pyruvate decarboxylation. Acetyl-CoA may then be used in the citric acid cycle to carry out cellular respiration, so pyruvate dehydrogenase contributes to linking the glycolysis metabolic pathway to the citric acid cycle and releasing energy via NADH. EC 1.2.4.1.

Pyruvate dehydrogenase is an autoantigen recognized in primary biliary cirrhosis, a form of acute liver failure. These antibodies appear to recognize oxidized protein that has resulted from inflammatory immune responses. Some of these inflammatory responses are explained by gluten sensitivity.

Pyruvate dehydrogenase (PDH) deficiency is a congenital degenerative metabolic disease resulting from a mutation of the pyruvate dehydrogenase complex (PDC) located on the X chromosome. Although defects have been identified in all 3 enzymes of the complex, the E1-α subunit is predominantly the culprit. Malfunction of the citric acid cycle due to PDH deficiency deprives the body of energy and leads to an abnormal buildup of lactate. PDH deficiency is a common cause of lactic acidosis in newborns and often presents with severe lethargy, poor feeding, tachypnea, and cases of death have occurred. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Pyruvate dehydrogenase

LOINC Names Get Info

Fully-Specified Name: Pyruvate dehydrogenase Ab.IgG:ACnc:Pt:Ser:Qn:IA
Long Common Name: Pyruvate dehydrogenase IgG Ab [Units/volume] in Serum by Immunoassay
Short Name: PDH IgG Ser IA-aCnc
Display Name: Pyruvate dehydrogenase IgG IA Qn (S)
Consumer Name Alpha Get Info: Pyruvate dehydrogenase IgG antibody, Blood

Part Model Get Info

Component
Pyruvate dehydrogenase Ab.IgG
LP146026-2
- Analyte
  Pyruvate dehydrogenase Ab.IgG
  LP146026-2
  - Component Numerator
    Pyruvate dehydrogenase Ab.IgG
    LP146026-2
    - Component Numerator Core
      Pyruvate dehydrogenase
      LP18605-3
    - Component Numerator Core Suffix
      Ab.IgG
      LP32401-9
  - Component Denominator
    NULL
    - Component Denominator Core
      NULL
    - Component Denominator Core Suffix
      NULL
- Challenge
  NULL
- Adjustment
  NULL
- Count
  NULL
Property
ACnc
LP6773-8
Time
Pt
LP6960-1
- Time Core
  Pt
  LP6960-1
- Time Modifier
  NULL
System
Ser
LP7567-3
- System Core
  Ser
  LP7567-3
- Super System
  NULL
Scale
Qn
LP7753-9
Method
IA
LP217197-5

Basic Attributes

Class: SERO
Type: Laboratory
First Released: Version 2.40
Last Updated: Version 2.70 (MIN)
Change Reason: The EIA method, which was always intended to cover more than just enzyme-linked immunoassay and whose display name for the long common name has always been Immunoassay, was renamed IA in order to eliminate ambiguity about whether the method has a broader meaning than just enzyme-linked immunoassay. Likewise, EIA.rapid was renamed IA.rapid. These changes were approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation: Both

Language Variants Get Info

Tag	Language	Translation
cs-CZ	Czech (Czechia)	Pyruvátdehydrogenáza IgG:Arbitrární koncentrace:Časový bod:Sérum:Kvantitativní:Imunoanalýza
el-GR	Greek (Greece)	Πυροσταφυλική αφυδρογονάση Αντισώματα IgG:ACnc:Pt:Ορός:Qn:IA Synonyms: ACnc IA Pt Qn SERO Ανοσοσφαιρίνη G Αντίσωμα Αντισώματα IgG Ορός Πυροσταφυλική αφυδρογονάση Πυροσταφυλικό οξύ
es-ES	Spanish (Spain)	Piruvato deshidrogenasa IgG:Concentración arbitraria:Punto temporal:Suero:Qn:IA Synonyms: Cuantitativo
es-MX	Spanish (Mexico)	Piruvato deshidrogenasa Ab.IgG:Concentración arbitraria:Punto temporal:Suero:Cuantitativo:Inmunoensayo
fr-FR	French (France)	Pyruvate déshydrogénase Ac IgG:Arbitraire/Volume:Ponctuel:Sérum:Numérique:Immunoanalyse
it-IT	Italian (Italy)	Piruvato deidrogenasi Ab.IgG:ACnc:Pt:Siero:Qn:IA Synonyms: anticorpi IgG anticorpo Concentrazione Arbitraria Immunoassay Punto nel tempo (episodio) Siero Sierologia (anticorpi e la maggior parte degli ant
nl-NL	Dutch (Netherlands)	pyruvaatdehydrogenase As.IgG:eenheid/volume:moment:serum:kwantitatief:immunoassay Synonyms: antistof; antilichaam IA
ru-RU	Russian (Russian Federation)	Пируват дегидрогеназа Ат.IgG:ПроизвКонц:ТчкВрм:Сыв:Колич:IA Synonyms: Антитело Количественный Пируватдегидрогеназа Произвольная концентрация Сыворотка Точка во времени;Момент
tr-TR	Turkish (Turkey)	Piruvat dehidrojenaz Ab.IgG:SçKons:Zmlı:Ser:Kant:İA Synonyms: Ak Ak.IgG İmmünölçüm, immünoassay
zh-CN	Chinese (China)	丙酮酸脱氢酶抗体.IgG:任意型浓度:时间点:血清:定量型:免疫测定法 Synonyms: Ab.IgG;IgG;抗体 IgG Ab;自身抗体 PDH;丙酮酸脱氢酶（Pyruvate Dehydrogenase，PDH）丙酮酸盐;丙酮酸酯任意型浓度(单位体积);任意浓度;单位体积的任意单位数;人工型浓度免疫测定;免疫分析法;免疫检定法;免疫检定;免疫试验;酶免疫测定法;酶免疫测定;酶免疫分析法;酶免疫检定法;酶免疫检定;酶免疫试验免疫球蛋白 G 去氢酶可用数量表示的;定量性;数值型;数量型;连续数值型标尺时刻;随机;随意;瞬间血清;血清学;血清学检验项目;血清学检验项目 (非微生物学);血清学检验项目（非微生物学）;血清学检验项目类;血清学检验项目类 (非微生物学);血清学类;血清学类检验项目;血清学类检验项目 (非微生物学);血清学类试验;血清学类试验 (非微生物学);血清学试验;血清学试验 (非微生物学);血清学试验（非微生物学）;血清学试验类 (非微生物学);血清类

Example Units

Unit	Source
[arb'U]/mL	Example UCUM Units

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LOINC Copyright

Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.