Version 2.78

Term Description

This term was created for (but not limited to) EUROIMMUN's Anti-Tyrosine Phosphatase (IA2) quantitative ELISA (IgG) test system for the in vitro determination of antibodies against tyrosine phosphatase (IA2) in human serum or EDTA plasma for the diagnosis of diabetes mellitus type I.
Source: Regenstrief LOINC

Part Description

LP28780-2   Islet cell 512
Islet cell antigen (ICA) 512 is a receptor-tyrosine phosphatase-like protein associated with the secretory granules of neuroendocrine cells. ICA-512 is also known as protein tyrosine phosphatase-IA2 (PTP-IA2) or tyrosine phosphatase (IA2). It is an autoantigen of type 1 diabetes. This is NOT the same as pancreatic islet cell. Studies on type-1 diabetic patient's relatives found that the development of one or more islet autoantibodies (including IA-2 antibody) was an early indicator of the relatives' progression to type-1 diabetes. Autoantibody profiles identifying patients destined to develop type-1 diabetes are usually detectable before age three. One study found that for relatives seropositive for IA-2 antibody, the likelihood of developing type-1 diabetes mellitus within five-years was 65.3%. Some type-1 diabetic patients are originally diagnosed as having type-2 diabetes due to symptom onset in adulthood, societal obesity, and initial insulin-independence. Detection of one or more islet auto-antibodies (including IA-2) may be used to distinguish these patients with "latent autoimmune diabetes" from type-2 diabetics. Source: Regenstrief Institute

Fully-Specified Name

Component
Islet cell 512 Ab.IgG
Property
PrThr
Time
Pt
System
Ser/Plas
Scale
Ord
Method
IA

Additional Names

Long Common Name
Islet cell 512 IgG Ab [Presence] in Serum or Plasma by Immunoassay
Short Name
Islet Cell512 IgG SerPl Ql IA
Display Name
Islet cell 512 IgG IA Ql
Consumer Name Alpha Get Info
Islet cell 512 IgG antibody, Blood

Example Answer List: LL360-9

Source: Regenstrief Institute
Answer Code Score Answer ID
PositiveCopyright http://snomed.info/sct ID:10828004 Positive (qualifier value) LA6576-8
NegativeCopyright http://snomed.info/sct ID:260385009 Negative (qualifier value) LA6577-6

Basic Attributes

Class
SERO
Type
Laboratory
First Released
Version 2.40
Last Updated
Version 2.56
Change Reason
The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.; The EIA method, which was always intended to cover more than just enzyme-linked immunoassay and whose display name for the long common name has always been Immunoassay, was renamed IA in order to eliminate ambiguity about whether the method has a broader meaning than just enzyme-linked immunoassay. Likewise, EIA.rapid was renamed IA.rapid. These changes were approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation
Both

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) Célula de los islotes 512 IgG:PrThr:Punto temporal:Suero o Plasma:Ord:IA
es-MX Spanish (Mexico) Celda de islotes 512 Ab.IgG:Presencia o umbral:Punto temporal:Suero o Plasma:Ordinal:Inmunoensayo
fr-CA French (Canada) ICA 512 d'îlots de Langerhans, IgG:Présence-Seuil:Temps ponctuel:Sérum/Plasma:Ordinal:IA
fr-FR French (France) Cellules îlots 512 anticorps IgG:Présence/Seuil:Ponctuel:Sérum/Plasma:Qualitatif:Immunoanalyse
fr-BE French (Belgium) ICA 512 d'îlots de Langerhans Anticorps. IgG:PrThr:Temps ponctuel:Sérum/Plasma:Ordinal:IA
Synonyms: Anticorps
it-IT Italian (Italy) Isola 512 cellula Ab.IgG:PrThr:Pt:Siero/Plasma:Ord:IA
Synonyms: anticorpi IgG anticorpo Immunoassay Plasma Presenza o Soglia Punto nel tempo (episodio) Siero Siero o Plasma Sierologia (anticorpi e la maggior parte degli ant
nl-NL Dutch (Netherlands) islet antigeen-2 As.IgG:aanwezigheid:moment:serum of plasma:ordinaal:immunoassay
Synonyms: antistof; antilichaam IA IA-2
pl-PL Polish (Poland) Komórki wyspowe 512 Ab.IgG:granica wykrywalności:punkt w czasie:surowica lub osocze:półilościowy:metoda immunologiczna
Synonyms: Antygen 512 komórek wyspowych IgG
pt-BR Portuguese (Brazil) Ilhotas células 512 Ac.IgG:Limiar:Pt:Soro/Plas:Ord:Imunoensaio
ru-RU Russian (Russian Federation) Островковая клетка 512 Ат.IgG:PrThr:ТчкВрм:Сыв/Плаз:Пор:IA
Synonyms: Антитело Плазма Порядковый Сыворотка Сыворотка или Плазма Точка во времени;Момент
tr-TR Turkish (Turkey) Adacık hücresi 512 Ab.IgG:MevcEşik:Zmlı:Ser/Plaz:Srl:İA
Synonyms: Ak Ak.IgG İmmünölçüm, immünoassay Mevcut
zh-CN Chinese (China) 岛细胞 512 抗体.IgG:存在情况或阈值:时间点:血清/血浆:序数型:免疫测定法
Synonyms: Ab.IgG;IgG;抗体 IgG Ab;自身抗体 IA-2;ICA;ICA512;小岛细胞 512;小岛细胞 512（Islet cell 512）;岛细胞 512（Islet cell 512）;这里的岛细胞（ Islet Cell）并不等同于胰岛细胞（ Pancreatic Islet Cell） ICA ICA512 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 免疫测定;免疫分析法;免疫检定法;免疫检定;免疫试验;酶免疫测定法;酶免疫测定;酶免疫分析法;酶免疫检定法;酶免疫检定;酶免疫试验 免疫球蛋白 G 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值） 小岛细胞 512 Ab 小岛细胞 512 抗体 岛细胞 512 Ab 时刻;随机;随意;瞬间 血清;血清学;血清学检验项目;血清学检验项目 (非微生物学);血清学检验项目（非微生物学）;血清学检验项目类;血清学检验项目类 (非微生物学);血清学类;血清学类检验项目;血清学类检验项目 (非微生物学);血清学类试验;血清学类试验 (非微生物学);血清学试验;血清学试验 (非微生物学);血清学试验（非微生物学）;血清学试验类 (非微生物学);血清类 血清或血浆

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