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Term Description

This term is used to identify a leukemia causing inversion on chromosome 16 resulting in gene fusion between CBFB (16q22) and MYH11 (16p13) genes. The term was created for (but not limited to) DNA Technology's HemaVision HV01-28N kit, a qualitative in vitro diagnostic test for 28 leukemia causing chromosomal alterations including more than 80 breakpoints plus associated mRNA splice variants. Reverse transcription followed by multiplex nested polymerase chain reactions (RT-PCR) and agarose gel electrophoresis are used to identify gene fusions caused by chromosomal translocations, gene deletions or inversions. Testing information is useful for predicting development of the disease and selection of treatment.

Part Description

LP146062-7   inv(16)(p13.1;q22.1)(MYH11,CBFB)
The inv(16)(p13.1;q22.1) CBFB-MYH11 fusion transcript is a chromosomal abnormality associated with acute myelomonocytic leukemia (AML). This results in the formation of a chimeric protein between core binding factor beta and smooth muscle myosin heavy chain 11. Positive results are indicative of AML subtype M4E0. Source: Regenstrief LOINC

LOINC Names Get Info

Fully-Specified Name
inv(16)(p13.1;q22.1)(MYH11,CBFB) fusion transcript:Arb:Pt:Bld/Tiss:Ord:Molgen
Long Common Name
inv(16)(p13.1;q22.1)(MYH11,CBFB) fusion transcript [Presence] in Blood or Tissue by Molecular genetics method
Short Name
inv(16)(p13;q22) Bld/T Ql
Display Name
inv(16)(p13.1;q22.1)(MYH11,CBFB) fusion transcript Molgen Ql (Bld/Tiss)
Consumer Name Alpha Get Info
inv(16)(p13.1;q22.1)(MYH11,CBFB) fusion transcript analysis, Blood or tissue specimen

Part Model Get Info

  • Component
    inv(16)(p13.1;q22.1)(MYH11,CBFB) fusion transcript
    LP228721-9
    • Analyte
      inv(16)(p13.1;q22.1)(MYH11,CBFB) fusion transcript
      LP228721-9
      • Component Numerator
        inv(16)(p13.1;q22.1)(MYH11,CBFB) fusion transcript
        LP228721-9
        • Component Numerator Core
          inv(16)(p13.1;q22.1)(MYH11,CBFB)
          LP146062-7
        • Component Numerator Core Suffix
          fusion transcript
          LP150217-0
      • Component Denominator
        NULL
         
        • Component Denominator Core
          NULL
           
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    Arb
    LP6781-1
  • Time
    Pt
    LP6960-1
  • System
    Bld/Tiss
    LP7061-7
    • System Core
      Bld/Tiss
      LP7061-7
    • Super System
      NULL
       
  • Scale
    Ord
    LP7751-3
  • Method
    Molgen
    LP6404-0

Example Answer List: LL360-9

Source: Regenstrief Institute
AnswerCodeScoreAnswer ID
PositiveCopyright http://snomed.info/sct ID:10828004 Positive (qualifier value)LA6576-8
NegativeCopyright http://snomed.info/sct ID:260385009 Negative (qualifier value)LA6577-6

Basic Attributes

Class
MOLPATH.INV
Type
Laboratory
First Released
Version 2.40
Last Updated
Version 2.73 (MIN)
Order vs. Observation
Both
Common Test Rank Get Info
5684

Member of these Panels

LOINCLong Common Name
72103-5Acute and chronic leukemia fusion transcript panel - Blood or Tissue by Molecular genetics method

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)Fúzní transkript inv(16)(p13.1;q22.1)(MYH11,CBFB):Arbitrární:Časový bod:Krev/tkáň:Ordinální:Molekulární genetika
de-ATGerman (Austria)Synonyms: MYH11-CBFB Inversion 16 (p13.1;q22.1)
el-GRGreek (Greece)inv(16)(p13.1;q22.1)(MYH11,CBFB) μεταγραφή συγχώνευσης:Arb:Pt:Αίμα/Ιστός:Ord:Μοριακή γενετική
Synonyms: Arb inv(16)(p13.1;q22.1)(MYH11,CBFB) MOLPATH MOLPATH.INV Ord Pt Αίμα Αίμα/Ιστός Ιστός μεταγραφή συγχώνευσης Μοριακή γενετική
es-ESSpanish (Spain)inv(16)(p13.1;q22.1)(MYH11,CBFB) Tránscritos de fusión:Arbitrario:Punto temporal:Sangre o tejido:Ord:Genética molecular
es-MXSpanish (Mexico)transcripción de fusión inv (16) (p13.1; q22.1) (MYH11, CBFB):Arbitrario:Punto temporal:Sangre o tejido:Ordinal:Genética molecular
fr-CAFrench (Canada)inv(16)(p13.1;q22.1)(MYH11,CBFB) transcrit de fusion:Arbitraire:Temps ponctuel:Sang/Tissu:Ordinal:Molgen
fr-FRFrench (France)inv(16)(p13.1;q22.1)(MYH11,CBFB) transcript de fusion:Arbitraire:Ponctuel:Sang/Tissu:Qualitatif:Biologie moléculaire
it-ITItalian (Italy)q22.1)(MYH11,CBFB)","inv(16)(p13.1, trascritto di fusione:Arb:Pt:Sangue/Tess:Ord:Molgen
Synonyms: Arbitrario Genetica molecolare Inversione genetica Patologia molecolare Punto nel tempo (episodio) q22.1)(MYH11,CBFB)",,06/08/2026 23:57:37 Sangue Sangue o Tessuto Tessuto & Strisci
nl-NLDutch (Netherlands)inv(16)(p13.1;q22.1)(MYH11,CBFB) fusietranscript:aanwezigheid:moment:bloed of weefsel:ordinaal:moleculair genetisch onderzoek
Synonyms: molgen
ru-RURussian (Russian Federation)inv(16)(p13.1;q22.1)(MYH11,CBFB) слияния транскрипт:Произв:ТчкВрм:Кр/Тк:Пор:МолГен
Synonyms: Кровь Кровь или Ткань Порядковый Произвольный Ткань и мазки Точка во времени;Момент химерная РНК, закодированная слитым геном
tr-TRTurkish (Turkey)inv(16)(p13.1;q22.1)(MYH11,CBFB) füzyon transkript:Sç:Zmlı:Kan/Dk:Srl:Molgen
zh-CNChinese (China)inv(16)(p13.1;q22.1)(MYH11,CBFB) 融合转录物:任意型:时间点:全血/组织:序数型:分子遗传学类实验室方法
Synonyms: 任意;任意的;人工型 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 倒位(16)(p13.1;q22.1)(MYH11,CBFB);基因倒位;基因倒置;倒位;倒置;gene inversion 全血或组织;血液/组织;血液或组织 分子病理学.基因倒位;分子病理学试验.基因倒位;分子病理学试验类.倒位 分子病理学;分子病理学试验 分子遗传学;分子遗传学方法;分子遗传学类方法;分子遗传学类检验方法;包括 RFL、PCR 及其他方法在内，用于在分子基础上检测遗传属性的方法的大类;聚合酶链反应;聚合酶链式反应 时刻;随机;随意;瞬间 未作说明的组织;组织;组织 & 涂片 融合转录物（转录本、转录产物、转录子、转录）;融合基因转录本;融合转录 血;血液

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