Version 2.80

Term Description

Determining the ratio of urinary-free cortisol to cortisone is useful in evaluating patients with apparent mineralocorticoid excess (AME) syndrome and other forms of adrenal insufficiency. Higher ratios (> 0.5) are observed in patients with AME syndrome and indicate insufficient levels of 11-beta-hydroxy steroid dehydrogenase type 2 (11-beta HSD2), which converts cortisol to cortisone. Lower ratios (<0.15) suggests low activity of the 11-beta-HSD1 enzyme, which converts cortisone to cortisol, and may explain reduced effectiveness of cortisone treatment.

Part Descriptions

LP29041-8   Cortisol.free
Cortisol is a glucocorticoid produced in the adrenal cortex. A synthetic version of this same chemical is called hydrocortisone and manufactured as medication. Cortisol is not to be confused with cortisone, a closely related compound with much less (PubChem calls it "inactive") biologic activity. Cortisone is also offered as a drug, and it is converted to cortisol (the active form) in the liver. They both have a circadian rhythm with peak in the AM (around 8AM) and trough in the evening (around midnight), but this shifts according to sleep habits (work shifts). The morning measurement, which should be high, is most useful for diagnosing Addison's disease (too little cortisol) and the evening measurement, which should be low, is the most useful for diagnosing Cushing's disease (too much cortisol). Salivary cortisol may be a more sensitive measure than serum or plasma. Source: Regenstrief Help

LP70341-0   Cortisone.free
Cortisol is a glucocorticoid produced in the adrenal cortex. A synthetic version of this same chemical is called hydrocortisone and manufactured as medication. Cortisol is not to be confused with cortisone, a closely related compound with much less (PubChem calls it "inactive") biologic activity. Cortisone is also offered as a drug, and it is converted to cortisol (the active form) in the liver. They both have a circadian rhythm with peak in the AM (around 8AM) and trough in the evening (around midnight), but this shifts according to sleep habits (work shifts). The morning measurement, which should be high, is most useful for diagnosing Addison's disease (too little cortisol) and the evening measurement, which should be low, is the most useful for diagnosing Cushing's disease (too much cortisol). Salivary cortisol may be a more sensitive measure than serum or plasma. Source: Regenstrief Help

Fully-Specified Name

Component
Cortisol.free/Cortisone.free
Property
SRto
Time
Pt
System
Urine
Scale
Qn
Method

Additional Names

Long Common Name
Cortisol Free/Cortisone free [Molar ratio] in Urine
Short Name
Cortis F/Cortisone Free Ur-sRto
Display Name
Cortisol Free/Cortisone free (U) [Molar ratio]
Consumer Name Alpha Get Info
Free cortisol/Free Cortisone, Urine

Basic Attributes

Class
CHEM
Type
Laboratory
First Released
Version 2.40
Last Updated
Version 2.42 (MIN)
Order vs. Observation
Both

Language Variants Get Info

Tag Language Translation
el-GR Greek (Greece) Κορτιζόλη.ελεύθερη/Κορτιζόνη.ελεύθερη:SRto:Pt:Ούρα:Qn:
Synonyms: SRto Κορτιζόλη Κορτιζόλη.ελεύθερη Κορτιζόνη Κορτιζόνη.ελεύθερη
es-ES Spanish (Spain) Cortisol libre/Cortisona Libre:Relacion de Sustancia:Punto temporal:Orina:Qn:
Synonyms: Cuantitativo
es-MX Spanish (Mexico) Cortisol.libre/Cortisone.libre:Proporción de sustancia:Punto temporal:Orina:Cuantitativo:
fr-FR French (France) Cortisol libre/cortisone libre:Moles ratio:Ponctuel:Urine:Numérique:
it-IT Italian (Italy) Cortisolo.libero/Cortisone.libero:Srto:Pt:Urine:Qn:
Synonyms: Chimica Cortisolo Libero Punto nel tempo (episodio) Rapporto di sostanza
nl-NL Dutch (Netherlands) cortisol.vrij/cortison.vrij:molaire verhouding:moment:urine:kwantitatief:
pt-BR Portuguese (Brazil) Cortisol.livre/Cortisona.livre::Pt:Urina:Qn:
ru-RU Russian (Russian Federation) Кортизол.свободный/Кортизон.свободный:МольОтн:ТчкВрм:Моча:Колич:
Synonyms: Количественный Мольная доля;Молярная доля;Отношение концентраций Точка во времени;Момент
tr-TR Turkish (Turkey) Kortizol.serb/Kortizon.serb:SOrn:Zmlı:İdrar:Kant:
Synonyms: SubsOranı
zh-CN Chinese (China) 皮质醇.游离型/可的松.游离型:物质的量比率:时间点:尿液:定量型:
Synonyms: 17羟11脱氢皮甾酮;17-羟-11-脱氢皮甾酮;化合物 E 17-羟皮质甾酮;17-羟皮质酮;化合物 F;可的索;氢化可的松;皮质甾醇;考的索 化学;化学检验项目;化学检验项目类;化学类;化学试验;非刺激耐受型化学检验项目;非刺激耐受型化学检验项目类;非刺激耐受型化学试验;非刺激耐受型化学试验类 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 可的松.游离 可的松.游离;游离可的松;游离型可的松 尿;小便;下泉 时刻;随机;随意;瞬间 游离 物质的量比值;物质的量比;摩尔比;摩尔比率;摩尔比值 皮质醇（可的索、考的索）.游离型;游离型皮质醇;游离皮质醇;皮质醇.游离 非蛋白结合型 非蛋白质结合型

Example Units

Unit Source
mol/mol Example UCUM Units

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CodeSystem lookup
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