71805-6

Cortisol Free/Cortisone free [Molar ratio] in Urine

Active

Term Description

Determining the ratio of urinary-free cortisol to cortisone is useful in evaluating patients with apparent mineralocorticoid excess (AME) syndrome and other forms of adrenal insufficiency. Higher ratios (> 0.5) are observed in patients with AME syndrome and indicate insufficient levels of 11-beta-hydroxy steroid dehydrogenase type 2 (11-beta HSD2), which converts cortisol to cortisone. Lower ratios (<0.15) suggests low activity of the 11-beta-HSD1 enzyme, which converts cortisone to cortisol, and may explain reduced effectiveness of cortisone treatment.

Part Descriptions

LP29041-8 Cortisol.free
Cortisol is a glucocorticoid produced in the adrenal cortex. A synthetic version of this same chemical is called hydrocortisone and manufactured as medication. Cortisol is not to be confused with cortisone, a closely related compound with much less (PubChem calls it "inactive") biologic activity. Cortisone is also offered as a drug, and it is converted to cortisol (the active form) in the liver. They both have a circadian rhythm with peak in the AM (around 8AM) and trough in the evening (around midnight), but this shifts according to sleep habits (work shifts). The morning measurement, which should be high, is most useful for diagnosing Addison's disease (too little cortisol) and the evening measurement, which should be low, is the most useful for diagnosing Cushing's disease (too much cortisol). Salivary cortisol may be a more sensitive measure than serum or plasma. Source: Regenstrief Help

LP70341-0 Cortisone.free
Cortisol is a glucocorticoid produced in the adrenal cortex. A synthetic version of this same chemical is called hydrocortisone and manufactured as medication. Cortisol is not to be confused with cortisone, a closely related compound with much less (PubChem calls it "inactive") biologic activity. Cortisone is also offered as a drug, and it is converted to cortisol (the active form) in the liver. They both have a circadian rhythm with peak in the AM (around 8AM) and trough in the evening (around midnight), but this shifts according to sleep habits (work shifts). The morning measurement, which should be high, is most useful for diagnosing Addison's disease (too little cortisol) and the evening measurement, which should be low, is the most useful for diagnosing Cushing's disease (too much cortisol). Salivary cortisol may be a more sensitive measure than serum or plasma. Source: Regenstrief Help

LOINC Names Get Info

Fully-Specified Name: Cortisol.free/Cortisone.free:SRto:Pt:Urine:Qn:
Long Common Name: Cortisol Free/Cortisone free [Molar ratio] in Urine
Short Name: Cortis F/Cortisone Free Ur-sRto
Display Name: Cortisol Free/Cortisone free (U) [Molar ratio]
Consumer Name Alpha Get Info: Free cortisol/Free Cortisone, Urine

Part Model Get Info

Component
Cortisol.free/Cortisone.free
LP285810-0
- Analyte
  Cortisol.free/Cortisone.free
  LP285810-0
  - Component Numerator
    Cortisol.free
    LP29041-8
    - Component Numerator Core
      Cortisol.free
      LP29041-8
    - Component Numerator Core Suffix
      NULL
  - Component Denominator
    Cortisone.free
    LP70341-0
    - Component Denominator Core
      Cortisone.free
      LP70341-0
    - Component Denominator Core Suffix
      NULL
- Challenge
  NULL
- Adjustment
  NULL
- Count
  NULL
Property
SRto
LP6868-6
Time
Pt
LP6960-1
- Time Core
  Pt
  LP6960-1
- Time Modifier
  NULL
System
Urine
LP7681-2
- System Core
  Urine
  LP7681-2
- Super System
  NULL
Scale
Qn
LP7753-9
Method
NULL

Basic Attributes

Class: CHEM
Type: Laboratory
First Released: Version 2.40
Last Updated: Version 2.42 (MIN)
Order vs. Observation: Both

Language Variants Get Info

Tag	Language	Translation
cs-CZ	Czech (Czechia)	Kortizol.volný/kortizon.volný:Látkový poměr:Časový bod:Moč:Kvantitativní:
el-GR	Greek (Greece)	Κορτιζόλη.ελεύθερη/Κορτιζόνη.ελεύθερη:SRto:Pt:Ούρα:Qn: Synonyms: CHEM Pt Qn SRto Κορτιζόλη Κορτιζόλη.ελεύθερη Κορτιζόνη Κορτιζόνη.ελεύθερη Ούρα
es-ES	Spanish (Spain)	Cortisol libre/Cortisona Libre:Relacion de Sustancia:Punto temporal:Orina:Qn: Synonyms: Cuantitativo
es-MX	Spanish (Mexico)	Cortisol.libre/Cortisone.libre:Proporción de sustancia:Punto temporal:Orina:Cuantitativo:
fr-FR	French (France)	Cortisol libre/cortisone libre:Moles ratio:Ponctuel:Urine:Numérique:
it-IT	Italian (Italy)	Cortisolo.libero/Cortisone.libero:Srto:Pt:Urine:Qn: Synonyms: Chimica Cortisolo Libero Punto nel tempo (episodio) Rapporto di sostanza
nl-NL	Dutch (Netherlands)	cortisol.vrij/cortison.vrij:molaire verhouding:moment:urine:kwantitatief:
pl-PL	Polish (Poland)	Kortyzol.wolny/kortyzon wolny:współczynnik molowy:punkt w czasie:mocz:ilościowy: Synonyms: Wolny kortyzon
ru-RU	Russian (Russian Federation)	Кортизол.свободный/Кортизон.свободный:МольОтн:ТчкВрм:Моча:Колич: Synonyms: Количественный Мольная доля;Молярная доля;Отношение концентраций Точка во времени;Момент
tr-TR	Turkish (Turkey)	Kortizol.serb/Kortizon.serb:SOrn:Zmlı:İdrar:Kant: Synonyms: SubsOranı
zh-CN	Chinese (China)	皮质醇.游离型/可的松.游离型:物质的量比率:时间点:尿液:定量型: Synonyms: 17羟11脱氢皮甾酮;17-羟-11-脱氢皮甾酮;化合物 E 17-羟皮质甾酮;17-羟皮质酮;化合物 F;可的索;氢化可的松;皮质甾醇;考的索化学;化学检验项目;化学检验项目类;化学类;化学试验;非刺激耐受型化学检验项目;非刺激耐受型化学检验项目类;非刺激耐受型化学试验;非刺激耐受型化学试验类可用数量表示的;定量性;数值型;数量型;连续数值型标尺可的松.游离可的松.游离;游离可的松;游离型可的松尿;小便;下泉时刻;随机;随意;瞬间游离物质的量比值;物质的量比;摩尔比;摩尔比率;摩尔比值皮质醇（可的索、考的索）.游离型;游离型皮质醇;游离皮质醇;皮质醇.游离非蛋白结合型非蛋白质结合型

Example Units

Unit	Source
mol/mol	Example UCUM Units

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LOINC Copyright

Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.