72216-5

t(15;17)(q24.1;q21.1)(PML,RARA) bcr1 fusion transcript/control transcript [# Ratio] in Blood or Tissue by Molecular genetics method

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Term Description

A balanced reciprocal translocation involving chromosomes 15 and 17, (15;17)(q22;q21), results in a fused transcript between PML and RARA genes. This gene fusion produces the PML-RARA fusion protein, a transcriptional repressor, which causes acute promyelocytic Leukemia (APL). Depending on the breakpoint within the PML gene, various fusion transcripts will be generated: long (L or bcr1), variant (V or bcr2), and short (S or bcr3). Techniques like real-time PCR are used to detect the PML-RARA fused transcripts and breakpoints. An endogenous control gene transcript (e.g. ABL1, GUS or BCR) is amplified along with the fusion transcript of interest. Standard curves of known amounts of both the control and fusion transcript are used to calculate the ratio of the fusion transcript signal to the control gene signal.
Source: Regenstrief LOINC

Part Description

LP101592-6 t(15;17)(q24.1;q21.1)(PML,RARA) bcr1
Three different breakpoint cluster regions (BCR1, BCR2, BCR3) on chromosome 15 leads to the formation of various types of PML-RARA fusion transcripts. BCR1 and BCR3 are most frequently involved in acute promyelocytic leukemia (APL), and BCR2 leads to several different products due to different breakpoints within this cluster. Source: Regenstrief LOINC

Fully-Specified Name

Component: t(15;17)(q24.1;q21.1)(PML,RARA) bcr1 fusion transcript/control transcript
Property: NRto
Time: Pt
System: Bld/Tiss
Scale: Qn
Method: Molgen

Additional Names

Long Common Name: t(15;17)(q24.1;q21.1)(PML,RARA) bcr1 fusion transcript/control transcript [# Ratio] in Blood or Tissue by Molecular genetics method
Short Name: t(15;17) BCR1/control Bld/T
Display Name: t(15;17)(q24.1;q21.1)(PML,RARA) bcr1 fusion transcript/control transcript Molgen (Bld/Tiss) [# ratio]
Consumer Name Alpha Get Info: t(15;17)(q24.1;q21.1)(PML,RARA) Bcr1/control Transcript, Blood or tissue specimen

Basic Attributes

Class: MOLPATH.TRNLOC
Type: Laboratory
First Released: Version 2.42
Last Updated: Version 2.73
Order vs. Observation: Both
Common Test Rank Get Info: 8858

Member of these Panels

LOINC	Long Common Name
72104-3	Acute and chronic leukemia fusion transcript per control transcript panel - Blood or Tissue by Molecular genetics method

Language Variants Get Info

Tag	Language	Translation
de-AT	German (Austria)	Synonyms: PML-RARA/BCR1 quantitativ
es-ES	Spanish (Spain)	bcr1 t(15;17)(q24.1;q21.1)(PML,RARA) Tránscritos de fusión/transcrito control:Relación de número:Punto temporal:Sangre o tejido:Qn:Genética molecular Synonyms: Cuantitativo
es-MX	Spanish (Mexico)	t (15; 17) (q24.1; q21.1) (PML, RARA) transcripción de fusión bcr1 / transcripción de control:Proporción numérica:Punto temporal:Sangre o tejido:Cuantitativo:Genética molecular
fr-FR	French (France)	t(15;17)(q24.1;q21.1)(PML,RARA) bcr1 transcrit de fusion/transcrit de référence:Nombre/Nombre:Ponctuel:Sang/Tissu:Numérique:Biologie moléculaire
fr-CA	French (Canada)	t(15;17)(q24.1;q21.1)(PML,RARA) bcr1 transcrit de fusion/Transcrit de contrôle:Ratio de numérique:Temps ponctuel:Sang/Tissu:Quantitatif:Molgen
it-IT	Italian (Italy)	t(15;17)(q24.1;q21.1)(PML,RARA) bcr1, trascritto di fusione/trascritto di controllo:NRto:Pt:Sangue/Tess:Qn:Molgen Synonyms: Genetica molecolare Patologia molecolare Punto nel tempo (episodio) Rapporto numerico Sangue Sangue o Tessuto Tessuto & Strisci Traslocazione genetica
nl-NL	Dutch (Netherlands)	t(15;17)(q24.1;q21.1)(PML,RARA) bcr1 fusietranscript/controle transcript:aantalsverhouding:moment:bloed of weefsel:kwantitatief:moleculair genetisch onderzoek Synonyms: molgen
pt-BR	Portuguese (Brazil)	t(15;17)(q24.1;q21.1)(PML,RARA) bcr1 transcrição de fusão/controle de transcrição::Pt:Sg/Tecido:Qn:Genética molecular
ru-RU	Russian (Russian Federation)	t(15;17)(q24.1;q21.1)(PML,RARA) bcr1 слияния транскрипт/контрольный транскрипт:КолОтн:ТчкВрм:Кр/Тк:Колич:МолГен Synonyms: Количественное отношение Количественный Кровь Кровь или Ткань Промиелоцитарный лейкоз Ткань и мазки Точка во времени;Момент химерная РНК, закодированная слитым геном
tr-TR	Turkish (Turkey)	t(15;17)(q24.1;q21.1)(PML,RARA) bcr1 füzyon transkript/kontrol transkripti:SayOr:Zmlı:Kan/Dk:Kant:Molgen
zh-CN	Chinese (China)	t(15;17)(q24.1;q21.1)(PML,RARA) bcr1 融合转录物/对照转录物:计数型比率:时间点:全血/组织:定量型:分子遗传学类实验室方法 Synonyms: MYL NR1B1 PML-1 PML-2 PML-3 PML-3B PML-X RAR alpha 型 RAR α型 RARalpha RARα 全血或组织;血液/组织;血液或组织分子病理学.基因易位;分子病理学.易位;分子病理学试验.基因易位;分子病理学试验.易位;分子病理学试验类.易位;基因易位分子病理学;分子病理学试验分子遗传学;分子遗传学方法;分子遗传学类方法;分子遗传学类检验方法;包括 RFL、PCR 及其他方法在内，用于在分子基础上检测遗传属性的方法的大类;聚合酶链反应;聚合酶链式反应前髓细胞白血病可用数量表示的;定量性;数值型;数量型;连续数值型标尺同一样本内两种不同实体的数量之比;数量型比;数量型比值;数量型比率;数量或计数型比;数量或计数型比值;计数型比;计数型比值;数量或计数型比率对照转录物（转录本、转录产物、转录子、转录）;对照基因转录本;控制转录本早幼粒细胞性白血病早幼粒细胞白血病早幼粒细胞白血病（Promyelocytic leukemia，PML）时刻;随机;随意;瞬间易位(15;17)(q24.1;q21.1)(PML,RARA) 易位(15;17)(q24.1;q21.1)(PML,RARA) bcr1 未作说明的组织;组织;组织 & 涂片融合转录物（转录本、转录产物、转录子、转录）;融合基因转录本;融合转录血;血液视黄酸受体 alpha 视黄酸受体 alpha（Retinoic acid receptor alpha，RARA，RARalpha，RAR alpha）视黄酸受体 α

Example Units

Unit	Source
%	Example UCUM Units

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