Version 2.78

Term Description

Test is to detect resistance of Mycobacterium tuberculosis strains to fluoroquinolones (FLQs) due to mutations present in the gyrA gene (coding for DNA gyrase). The types of mutations present or absent indicate if the isolate is susceptible or resistant to fluoroquinolones. This code is based on, but not limited in use to, the submitter's test kit: HAIN Lifescience's GenoType MTBDRsl.
Source: Regenstrief LOINC

Part Description

LP267987-8   Mycobacterium tuberculosis gyrA gene fluoroquinolone resistance mutation
Fluorquinolones are among most beneficial drugs used to treat multi-drug resistant Mycobacterium tuberculosis (MDR-TB) infections. The fluorquinolones affect the activity of DNA gyrase by reducing the cell's ability for DNA replication and transcription. DNA gyrase in Mycobacterium tuberculosis (TB) is made of two subunits that are encoded by gyrA and gyrB. Mutations in the gyrA quinolone resistance-determining region (QRDR) are responsible for causing most of the drug resistance of TB to the fluoroquinolones. The gyrB mutations have a much smaller impact on TB resistance to the fluoroquinolones. PMID: 26763957 Source: Regenstrief LOINC

Fully-Specified Name

Component
Mycobacterium tuberculosis gyrA gene fluoroquinolone resistance mutation
Property
PrThr
Time
Pt
System
Isolate/Specimen
Scale
Ord
Method
Molgen

Additional Names

Short Name
MTB gyrA fluoroquin res mut Islt/Spm Ql
Display Name
M. tuberculosis gyrA gene fluoroquinolone resistance mutation Molgen Ql (Islt/Spec)
Consumer Name Alpha Get Info
Mycobacterium tuberculosis gyrA gene fluoroquinolone resistance mutation

Example Answer List: LL1908-4

Source: LOINC partner 1
Answer Code Score Answer ID
Sensitive LA16549-0
Resistant LA6676-6
Resistance possible LA17970-7

Basic Attributes

Class
ABXBACT
Type
Laboratory
First Released
Version 2.42
Last Updated
Version 2.65
Change Reason
The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.; Updated Component to reflect that gyrA is a native gene in which a mutation causes fluoroquinolone resistance, System from "Isolate", and Method from "Probe.amp.tar" according to the new sustainable model for LOINC molecular resistance terms [Approved by LOINC Laboratory Committee in June 2018].
Order vs. Observation
Both

Language Variants Get Info

Tag Language Translation
de-AT German (Austria) Synonyms: M.tuberculosis-Fluorchinolon-Resistenz PCR /SM
de-DE German (Germany) Mycobacterium tuberculosis gyrA-Gen Fluorchinolon-Resistenz-Mutation:Nachweis oder Schwellenwert:Zeitpunkt:Isolat oder Probenmaterial:Ordinal:Molekulargenetisch
es-ES Spanish (Spain) Mutación del gen gyrA de Mycobacterium tuberculosis resistente a la fluoroquinolona:PrThr:Punto temporal:Muestra aislada:Ord:Genética molecular
es-MX Spanish (Mexico) Mutación de resistencia a fluoroquinolonas del gen gyrA de Mycobacterium tuberculosis:Presencia o umbral:Punto temporal:Aislado o espécimen:Ordinal:Genética molecular
fr-FR French (France) Mycobacterium tuberculosis résistance aux fluoroquinolones gyrA mutation gène:Présence/Seuil:Ponctuel:Isolat/échantillon:Qualitatif:Biologie moléculaire
it-IT Italian (Italy) Mycobacterium tuberculosis, gene gyrA fluorochinolone resistente:PrThr:Pt:Isolato/Campione:Ord:Molgen
Synonyms: Genetica molecolare Isolato o Campione Micobatterio della tubercolosi Presenza o Soglia Punto nel tempo (episodio) Suscettibilità agli antibiotici
nl-NL Dutch (Netherlands) Mycobacterium tuberculosis gyrA-gen fluorchinolonresistentie:aanwezigheid:moment:isolaat of monster:ordinaal:moleculair genetisch onderzoek
Synonyms: isolaat/specimen molgen
pt-BR Portuguese (Brazil) Mycobacterium tuberculosis fluoroquinolone resistente (gyrA) gene::Pt:Isolado:Ord:Sonda com limite de detecção da amplificação de alvo
zh-CN Chinese (China) 结核分枝杆菌 gyrA 基因氟喹诺酮耐药性突变:存在情况或阈值:时间点:分离株/标本:序数型:分子遗传学类实验室方法
Synonyms: AFB 供检查用的材料;待检物;待试验物;样品;样本;试料;试样 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 分子遗传学;分子遗传学方法;分子遗传学类方法;分子遗传学类检验方法;包括 RFL、PCR 及其他方法在内，用于在分子基础上检测遗传属性的方法的大类;聚合酶链反应;聚合酶链式反应 分支杆菌 分支杆菌属 分枝杆菌属 分离株/标本（样本、样品、试样） 分离物;分离菌;分离菌株;隔离种群 劳瘵 受检物 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值） 抗力 抗生素敏感性试验;药敏;药敏类;药敏试验;药敏试验类 抗耐性 抗酸 抗酸杆菌 抗酸杆菌（Acid fast bacillus，AFB） 抗酸菌 抵抗力 抵抗性 时刻;随机;随意;瞬间 样品 样本 氟喹诺酮类抗生素;氟喹诺酮类药物 电阻 痨 痨病 结核 结核;肺结核;痨;痨病;TB 结核分支杆菌;结核杆菌;结核菌 结核分枝杆菌（结核分支杆菌、结核杆菌、结核菌） gyrA 基因氟喹诺酮（氟喹诺酮类药物、氟喹诺酮类、氟化苯酚酮）耐药性（抗性、耐性、耐药、抗药、抗药性、耐受、耐药型）突变 结核病 耐性 肺结核 试样 遗传基因;遗传因子;吉恩;生物基因 阻力

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=72276-9