72276-9

Mycobacterium tuberculosis gyrA gene fluoroquinolone resistance mutation [Presence] by Molecular method

Active

Term Description

Test is to detect resistance of Mycobacterium tuberculosis strains to fluoroquinolones (FLQs) due to mutations present in the gyrA gene (coding for DNA gyrase). The types of mutations present or absent indicate if the isolate is susceptible or resistant to fluoroquinolones. This code is based on, but not limited in use to, the submitter's test kit: HAIN Lifescience's GenoType MTBDRsl.

Part Description

LP267987-8 Mycobacterium tuberculosis gyrA gene fluoroquinolone resistance mutation
Fluorquinolones are among most beneficial drugs used to treat multi-drug resistant Mycobacterium tuberculosis (MDR-TB) infections. The fluorquinolones affect the activity of DNA gyrase by reducing the cell's ability for DNA replication and transcription. DNA gyrase in Mycobacterium tuberculosis (TB) is made of two subunits that are encoded by gyrA and gyrB. Mutations in the gyrA quinolone resistance-determining region (QRDR) are responsible for causing most of the drug resistance of TB to the fluoroquinolones. The gyrB mutations have a much smaller impact on TB resistance to the fluoroquinolones. PMID: 26763957 Source: Regenstrief LOINC

LOINC Names Get Info

Fully-Specified Name: Mycobacterium tuberculosis gyrA gene fluoroquinolone resistance mutation:PrThr:Pt:Isolate/Specimen:Ord:Molgen
Long Common Name: Mycobacterium tuberculosis gyrA gene fluoroquinolone resistance mutation [Presence] by Molecular method
Short Name: MTB gyrA fluoroquin res mut Islt/Spm Ql
Display Name: M. tuberculosis gyrA gene fluoroquinolone resistance mutation Molgen Ql (Islt/Spec)
Consumer Name Alpha Get Info: Mycobacterium tuberculosis gyrA gene fluoroquinolone resistance mutation

Part Model Get Info

Component
Mycobacterium tuberculosis gyrA gene fluoroquinolone resistance mutation
LP267987-8
- Analyte
  Mycobacterium tuberculosis gyrA gene fluoroquinolone resistance mutation
  LP267987-8
  - Component Numerator
    Mycobacterium tuberculosis gyrA gene fluoroquinolone resistance mutation
    LP267987-8
    - Component Numerator Core
      Mycobacterium tuberculosis gyrA gene fluoroquinolone resistance mutation
      LP267987-8
    - Component Numerator Core Suffix
      NULL
  - Component Denominator
    NULL
    - Component Denominator Core
      NULL
    - Component Denominator Core Suffix
      NULL
- Challenge
  NULL
- Adjustment
  NULL
- Count
  NULL
Property
PrThr
LP217195-9
Time
Pt
LP6960-1
- Time Core
  Pt
  LP6960-1
- Time Modifier
  NULL
System
Isolate/Specimen
LP266970-5
- System Core
  Isolate/Specimen
  LP266970-5
- Super System
  NULL
Scale
Ord
LP7751-3
Method
Molgen
LP6404-0

Example Answer List: LL1908-4

Source: LOINC partner 1

Answer	Code	Score	Answer ID
Sensitive			LA16549-0
Resistant			LA6676-6
Resistance possible			LA17970-7

Basic Attributes

Class: ABXBACT
Type: Laboratory
First Released: Version 2.42
Last Updated: Version 2.65 (NAM)
Change Reason: The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.; Updated Component to reflect that gyrA is a native gene in which a mutation causes fluoroquinolone resistance, System from "Isolate", and Method from "Probe.amp.tar" according to the new sustainable model for LOINC molecular resistance terms [Approved by LOINC Laboratory Committee in June 2018].
Order vs. Observation: Both

Language Variants Get Info

Tag	Language	Translation
cs-CZ	Czech (Czechia)	Mycobacterium tuberculosis gen gyrA rezistence na fluorochinolony mutace:Přítomnost nebo práh:Časový bod:Izolát/vzorek:Ordinální:Molekulární genetika
de-AT	German (Austria)	Synonyms: M.tuberculosis-Fluorchinolon-Resistenz PCR /SM
de-DE	German (Germany)	Mycobacterium tuberculosis gyrA-Gen Fluorchinolon-Resistenz-Mutation:Nachweis oder Schwellenwert:Zeitpunkt:Isolat oder Probenmaterial:Ordinal:Molekulargenetisch
el-GR	Greek (Greece)	Μετάλλαξη ανθεκτικότητας του γονιδίου gyrA του Mycobacterium tuberculosis (Μυκοβακτηρίδιο της φυματίωσης) στις φθοριοκινολόνες:PrThr:Pt:Απομονωθέν στέλεχος/Δείγμα:Ord:Μοριακή γενετική Synonyms: ABXBACT Mycobacterium tuberculosis (Μυκοβακτηρίδιο της φυματίωσης) Ord PrThr Pt Απομονωθέν στέλεχος/Δείγμα Απομονωμένο στέλεχος Γονίδιο Δείγμα Μετάλλαξη ανθεκτικότητας του γονιδίου gyrA του Mycobacterium tuberculosis (Μυκοβακτηρίδιο της φυματίωσης) στις φθοριοκινολόνες Μοριακή γενετική Φθοριοκινολόνη
es-ES	Spanish (Spain)	Mutación del gen gyrA de Mycobacterium tuberculosis resistente a la fluoroquinolona:PrThr:Punto temporal:Muestra aislada:Ord:Genética molecular
es-MX	Spanish (Mexico)	Mutación de resistencia a fluoroquinolonas del gen gyrA de Mycobacterium tuberculosis:Presencia o umbral:Punto temporal:Aislado o espécimen:Ordinal:Genética molecular
fr-FR	French (France)	Mycobacterium tuberculosis mutation de résistance aux fluoroquinolones gène gyrA:Présence/Seuil:Ponctuel:Isolat/échantillon:Qualitatif:Biologie moléculaire
it-IT	Italian (Italy)	Mycobacterium tuberculosis, gene gyrA fluorochinolone resistente:PrThr:Pt:Isolato/Campione:Ord:Molgen Synonyms: Genetica molecolare Isolato o Campione Micobatterio della tubercolosi Presenza o Soglia Punto nel tempo (episodio) Suscettibilità agli antibiotici
nl-NL	Dutch (Netherlands)	Mycobacterium tuberculosis gyrA-gen fluorchinolonresistentie:aanwezigheid:moment:isolaat of monster:ordinaal:moleculair genetisch onderzoek Synonyms: isolaat/specimen molgen
pl-PL	Polish (Poland)	Mycobacterium tuberculosis gyrA gen mutacja oporności na fluorochinolony:granica wykrywalności:punkt w czasie:szczep/izolat lub próbka:uporządkowany:genetyka molekularna Synonyms: diagnostyka molekularna Mutacja w genie gyrA Mycobacterium tuberculosis warunkująca oporność na fluorochinolony;Mutacja w genie gyrA Mycobacterium tuberculosis odpowiedzialna za oporność na fluorochinolony Prątek gruźlicy
zh-CN	Chinese (China)	结核分枝杆菌 gyrA 基因氟喹诺酮耐药性突变:存在情况或阈值:时间点:分离株/标本:序数型:分子遗传学类实验室方法 Synonyms: AFB 供检查用的材料;待检物;待试验物;样品;样本;试料;试样依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型分子遗传学;分子遗传学方法;分子遗传学类方法;分子遗传学类检验方法;包括 RFL、PCR 及其他方法在内，用于在分子基础上检测遗传属性的方法的大类;聚合酶链反应;聚合酶链式反应分支杆菌分支杆菌属分枝杆菌属分离株/标本（样本、样品、试样）分离物;分离菌;分离菌株;隔离种群劳瘵受检物存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值）抗力抗生素敏感性试验;药敏;药敏类;药敏试验;药敏试验类抗耐性抗酸抗酸杆菌抗酸杆菌（Acid fast bacillus，AFB）抗酸菌抵抗力抵抗性时刻;随机;随意;瞬间样品样本氟喹诺酮类抗生素;氟喹诺酮类药物电阻痨痨病结核结核;肺结核;痨;痨病;TB 结核分支杆菌;结核杆菌;结核菌结核分枝杆菌（结核分支杆菌、结核杆菌、结核菌） gyrA 基因氟喹诺酮（氟喹诺酮类药物、氟喹诺酮类、氟化苯酚酮）耐药性（抗性、耐性、耐药、抗药、抗药性、耐受、耐药型）突变结核病耐性肺结核试样遗传基因;遗传因子;吉恩;生物基因阻力

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Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.