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Term Description

A translocation involving chromosomes 1 and 19, t(1;19)(q23;p13), results in a fused transcript between TCF3 (formerly E2A) and PBX1 (formerly prl) genes. The TCF3-PBX1 fusion gene is found in approximately 3% of childhood and adult precursor-B acute lymphoblastic leukemia (ALL). This code is based on, but not limited to, Ispogen's E2A-PBX1 FusionQuant® kit, which uses real-time Quantitative RQ-PCR to quantify the expression level of specific TCF3(E2A)-PBX1 fusion gene transcripts relative to a control gene transcript (e.g. ABL1). From the manufacturer's website (2012), "Quantification of E2A-PBX1 fusion gene transcripts has been standardized in the EAC (Europe Against Cancer) program [Gabert J et al. Leukemia. 2003, Beillard E et al. Leukemia. 2003], and IPSOGEN FusionQuant® kits use this validated technology to calibrate and normalize RQ-PCR results."

Part Description

LP19829-8   t(1;19)(q23.3;p13.3)(PBX1,TCF3)
Chromosomal translocation t(1;19)(q23.3;p13.3) PBX1/TCF3 is caused by a breakpoint in 19p13.3 and occurs in two different forms: 1) a balanced form found in one fourth of cases with a der(1) and a der(19) and 2) an unbalanced form found in 3/4 cases with 2 normal chromosomes 1, a der(19), and 1 normal chromosome 19. This translocation is mostly found in acute lymphoblastic leukemia (ALL), L1/L2 type, as well as L3-like ALL, T-lineage ALL (T-ALL), non-Hodgkin lymphomas (NHL), and acute myeloid leukemias (AML).[Atlas Genetics Oncology:t0119ID1048] Source: Regenstrief LOINC, t(1;19)(q23;p13) TCF3/PBX1

LOINC Names Get Info

Fully-Specified Name
t(1;19)(q23.3;p13.3)(PBX1,TCF3) fusion transcript/control transcript:NRto:Pt:Bld/Tiss:Qn:Molgen
Long Common Name
t(1;19)(q23.3;p13.3)(PBX1,TCF3) fusion transcript/control transcript [# Ratio] in Blood or Tissue by Molecular genetics method
Short Name
t(1;19)(PBX1,TCF3)/control Bld/T
Display Name
t(1;19)(q23.3;p13.3)(PBX1,TCF3) fusion transcript/control transcript Molgen (Bld/Tiss) [# ratio]
Consumer Name Alpha Get Info
t(1;19)(q23.3;p13.3)(PBX1,TCF3)/control Transcript, Blood or tissue specimen

Part Model Get Info

  • Component
    t(1;19)(q23.3;p13.3)(PBX1,TCF3) fusion transcript/control transcript
    LP287169-9
    • Analyte
      t(1;19)(q23.3;p13.3)(PBX1,TCF3) fusion transcript/control transcript
      LP287169-9
      • Component Numerator
        t(1;19)(q23.3;p13.3)(PBX1,TCF3) fusion transcript
        LP229723-4
        • Component Numerator Core
          t(1;19)(q23.3;p13.3)(PBX1,TCF3)
          LP19829-8
        • Component Numerator Core Suffix
          fusion transcript
          LP150217-0
      • Component Denominator
        control transcript
        LP150246-9
        • Component Denominator Core
          control transcript
          LP150246-9
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    NRto
    LP6840-5
  • Time
    Pt
    LP6960-1
  • System
    Bld/Tiss
    LP7061-7
    • System Core
      Bld/Tiss
      LP7061-7
    • Super System
      NULL
       
  • Scale
    Qn
    LP7753-9
  • Method
    Molgen
    LP6404-0

Basic Attributes

Class
MOLPATH.TRNLOC
Type
Laboratory
First Released
Version 2.42
Last Updated
Version 2.42 (MIN)
Order vs. Observation
Both

Member of these Panels

LOINCLong Common Name
72104-3Acute and chronic leukemia fusion transcript per control transcript panel - Blood or Tissue by Molecular genetics method

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)Fúzní transkript t(1;19)(q23.3;p13.3)(PBX1,TCF3)/kontrolní transkript:Početní poměr:Časový bod:Krev/tkáň:Kvantitativní:Molekulární genetika
el-GRGreek (Greece)t(1;19)(q23.3;p13.3)(PBX1,TCF3) μεταγραφή συγχώνευσης/μεταγραφή ελέγχου:NRto:Pt:Αίμα/Ιστός:Qn:Μοριακή γενετική
Synonyms: MOLPATH MOLPATH.TRNLOC NRto Pt Qn t(1;19)(q23.3;p13.3)(PBX1,TCF3) Αίμα Αίμα/Ιστός Ιστός μεταγραφή ελέγχου μεταγραφή συγχώνευσης Μοριακή γενετική
es-ESSpanish (Spain)t(1;19)(q23.3;p13.3)(PBX1,TCF3) Tránscritos de fusión/transcrito control:Relación de número:Punto temporal:Sangre o tejido:Qn:Genética molecular
Synonyms: Cuantitativo
es-MXSpanish (Mexico)t (1; 19) (q23.3; p13.3) (PBX1, TCF3) transcripción de fusión / transcripción de control:Proporción numérica:Punto temporal:Sangre o tejido:Cuantitativo:Genética molecular
fr-FRFrench (France)t(1;19)(q23.3;p13.3)(PBX1,TCF3) transcript de fusion/transcrit de référence:Nombre/Nombre:Ponctuel:Sang/Tissu:Numérique:Biologie moléculaire
fr-CAFrench (Canada)t(1;19)(q23.3;p13.3)(PBX1,TCF3) transcrit de fusion/Transcrit de contrôle:Ratio de numérique:Temps ponctuel:Sang/Tissu:Quantitatif:Molgen
it-ITItalian (Italy)t(1,19)(q23.3,p13.3)(PBX1,TCF3), trascritto di fusione/trascritto di controllo:NRto:Pt:Sangue/Tess:Qn:Molgen
Synonyms: Genetica molecolare Patologia molecolare Punto nel tempo (episodio) Rapporto numerico Sangue Sangue o Tessuto Tessuto & Strisci Traslocazione genetica
nl-NLDutch (Netherlands)t(1;19)(q23.3;p13.3)(PBX1,TCF3) fusietranscript/controle transcript:aantalsverhouding:moment:bloed of weefsel:kwantitatief:moleculair genetisch onderzoek
Synonyms: molgen
ru-RURussian (Russian Federation)t(1;19)(q23.3;p13.3)(PBX1,TCF3) слияния транскрипт/контрольный транскрипт:КолОтн:ТчкВрм:Кр/Тк:Колич:МолГен
Synonyms: Количественное отношение Количественный Кровь Кровь или Ткань Ткань и мазки Точка во времени;Момент химерная РНК, закодированная слитым геном
tr-TRTurkish (Turkey)t(1;19)(q23.3;p13.3)(PBX1,TCF3) füzyon transkript/kontrol transkripti:SayOr:Zmlı:Kan/Dk:Kant:Molgen
zh-CNChinese (China)t(1;19)(q23.3;p13.3)(PBX1,TCF3) 融合转录物/对照转录物:计数型比率:时间点:全血/组织:定量型:分子遗传学类实验室方法
Synonyms: Ⅰ E2A 免疫球蛋白增强子结合因子 E12/E47 E2A 免疫球蛋白增强子结合因子 E12/E47（E2A Immunoglobulin enhancer binding factors E12/E47） I ITF1 PBXP1 T(1,19)(PBX1,TCF3) 基因易位;T(1,19)(PBX1,TCF3) 易位 免疫球蛋白转录因子 1 免疫球蛋白转录因子 1（Immunoglobulin transcription factor 1，ITF1） 全血或组织;血液/组织;血液或组织 分子病理学.基因易位;分子病理学.易位;分子病理学试验.基因易位;分子病理学试验.易位;分子病理学试验类.易位;基因易位 分子病理学;分子病理学试验 分子遗传学;分子遗传学方法;分子遗传学类方法;分子遗传学类检验方法;包括 RFL、PCR 及其他方法在内，用于在分子基础上检测遗传属性的方法的大类;聚合酶链反应;聚合酶链式反应 前 B 细胞白血病转录因子-1 前 B-细胞白血病转录因子-1 前 B-细胞白血病转录因子-1（Pre-B cell leukemia transcription factor-1，PBX1，PBXP1） 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 同一样本内两种不同实体的数量之比;数量型比;数量型比值;数量型比率;数量或计数型比;数量或计数型比值;计数型比;计数型比值;数量或计数型比率 对照转录物（转录本、转录产物、转录子、转录）;对照基因转录本;控制转录本 时刻;随机;随意;瞬间 未作说明的组织;组织;组织 & 涂片 融合转录物（转录本、转录产物、转录子、转录）;融合基因转录本;融合转录 血;血液 转录因子 3 转录因子 3（Transcription factor 3，TCF3）

Example Units

UnitSource
%Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=72312-2