Version 2.78

Term Description

Th/To IgG class autoantibodies can be detected on immunoblot strips and visualized by enzyme-labeled reactions. Results may be interpreted by humans or automated methods and used for the diagnosis of system sclerosis (SSc, diffuse and limited forms) and overlapping syndromes. This code was created for, but not limited to, the detection of Th/To autoantibodies in Euroimmun's Systemic Sclerosis (Nucleoli) Profile EUROLINE (IgG) test kit.
Source: Regenstrief LOINC

Part Descriptions

LP157203-3   Th-To Ab.IgG
Patient's with Th/To autoantibodies immunoprecipitate two small RNAs, known as 7-2 RNA (also RNAase MRP or Th) and 8-2 RNA (also RNAase P, H1 and To). 7-2 RNA is involved in processing of pre-rRNA and 8-2 RNA is involved in maturation of tRNA. Anti-Th/To is frequently detected in the sera of patients with scleroderma and their presence may be associated with a less favorable prognosis. Source: Regenstrief LOINC, PMID: 20175839

LP157267-8   Th-To
Th/To are small nuclear ribonucleoproteins located in the nucleoli of cells. Anti-Th/To antibodies, a type of antinuclear antibodies (ANA), are present in a small subset (2-5%) of patients with with limited cutaneous systemic sclerosis (lSSc). But they present a higher risk for severe organ involvement and therefore a worse prognosis. Severe pulmonary fibrosis followed by pulmonary hypertension have been reported. Source: Regenstrief LOINC, PMID: 20175839

Fully-Specified Name

Component
Th-To Ab.IgG
Property
PrThr
Time
Pt
System
Ser/Plas
Scale
Ord
Method
IA

Additional Names

Short Name
Th-To IgG SerPl Ql IA
Display Name
Th-To IgG IA Ql
Consumer Name Alpha Get Info
Th-To IgG antibody, Blood

Example Answer List: LL2206-2

Source: Estonian Society of Laboratory Medicine
Answer Code Score Answer ID
NegativeCopyright http://snomed.info/sct ID:260385009 Negative (qualifier value) LA6577-6
Borderline LA4259-3
PositiveCopyright http://snomed.info/sct ID:10828004 Positive (qualifier value) LA6576-8
Strong positive LA18996-1

Basic Attributes

Class
SERO
Type
Laboratory
First Released
Version 2.42
Last Updated
Version 2.56
Change Reason
The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.; The EIA method, which was always intended to cover more than just enzyme-linked immunoassay and whose display name for the long common name has always been Immunoassay, was renamed IA in order to eliminate ambiguity about whether the method has a broader meaning than just enzyme-linked immunoassay. Likewise, EIA.rapid was renamed IA.rapid. These changes were approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation
Both

Language Variants Get Info

Tag Language Translation
de-AT German (Austria) Synonyms: Th/To AK IgG qualitativ
es-ES Spanish (Spain) Th-To IgG:PrThr:Punto temporal:Suero o Plasma:Ord:IA
es-MX Spanish (Mexico) Th-To Ab.IgG:Presencia o umbral:Punto temporal:Suero o Plasma:Ordinal:Inmunoensayo
fr-FR French (France) Th-To anticorps IgG:Présence/Seuil:Ponctuel:Sérum/Plasma:Qualitatif:Immunoanalyse
it-IT Italian (Italy) Th-To Ab.IgG:PrThr:Pt:Siero/Plasma:Ord:IA
Synonyms: anticorpi IgG anticorpo Immunoassay Plasma Presenza o Soglia Punto nel tempo (episodio) Siero Siero o Plasma Sierologia (anticorpi e la maggior parte degli ant
nl-NL Dutch (Netherlands) Th-To As.IgG:aanwezigheid:moment:serum of plasma:ordinaal:immunoassay
Synonyms: antistof; antilichaam IA
pt-BR Portuguese (Brazil) Th-To Ac.IgG:Limiar:Pt:Soro/Plas:Ord:Imunoensaio
ru-RU Russian (Russian Federation) Th-To Ат.IgG:PrThr:ТчкВрм:Сыв/Плаз:Пор:IA
Synonyms: Антитело Плазма Порядковый Сыворотка Сыворотка или Плазма Точка во времени;Момент
tr-TR Turkish (Turkey) Th-To Ab.IgG:MevcEşik:Zmlı:Ser/Plaz:Srl:İA
Synonyms: Ak Ak.IgG İmmünölçüm, immünoassay Mevcut
zh-CN Chinese (China) Th-To 抗体.IgG:存在情况或阈值:时间点:血清/血浆:序数型:免疫测定法
Synonyms: Ab.IgG;IgG;抗体 IgG Ab;自身抗体 Th/To;核内小核糖核蛋白;systemic sclerosis;系统性硬化病;硬皮病;SSc;PM/Scl overlap syndrome;系统性硬化病与多发性肌炎重叠综合征 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 免疫测定;免疫分析法;免疫检定法;免疫检定;免疫试验;酶免疫测定法;酶免疫测定;酶免疫分析法;酶免疫检定法;酶免疫检定;酶免疫试验 免疫球蛋白 G 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值） 时刻;随机;随意;瞬间 血清;血清学;血清学检验项目;血清学检验项目 (非微生物学);血清学检验项目（非微生物学）;血清学检验项目类;血清学检验项目类 (非微生物学);血清学类;血清学类检验项目;血清学类检验项目 (非微生物学);血清学类试验;血清学类试验 (非微生物学);血清学试验;血清学试验 (非微生物学);血清学试验（非微生物学）;血清学试验类 (非微生物学);血清类 血清或血浆 钍

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