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Part Description

LP18451-2   Phenyllactate
L-3-Phenyllactic acid (or PLA) is a chiral aromatic compound involved in phenylalanine metabolism. It is likely produced from phenylpyruvate via the action of lactate dehydrogenase. The D-form of this organic acid is typically derived from bacterial sources while the L-form is almost certainly endogenous. Levels of phenyllactate are normally very low in blood or urine. High levels of PLA in the urine or blood are often indicative of phenylketonuria (PKU) and hyperphenylalaninemia (HPA). PKU is due to lack of the enzyme phenylalanine hydroxylase (PAH), so that phenylalanine is converted not to tyrosine but to phenylpyruvic acid (a precursor of phenylactate). In particular, excessive phenylalanine is typically metabolized into phenylketones through, a transaminase pathway route involving glutamate. Metabolites of this transamination reaction include phenylacetate, phenylpyruvate and phenethylamine. In persons with PKU, dietary phenylalanine either accumulates in the body or some of it is converted to phenylpyruvic acid and then to phenyllactate through the action of lactate dehydrogenase. Individuals with PKU tend to excrete large quantities of phenylpyruvate, phenylacetate and phenyllactate, along with phenylalanine, in their urine. If untreated, mental retardation effects and microcephaly are evident by the first year along with other symptoms which include: unusual irritability, epileptic seizures and skin lesions. Hyperactivity, EEG abnormalities and seizures, and severe learning disabilities are major clinical problems later in life. A "musty or mousy" odor of skin, hair, sweat and urine (due to phenylacetate accumulation); and a tendency to hypopigmentation and eczema are also observed. The neural-development effects of PKU are primarily due to the disruption of neurotransmitter synthesis. In particular, phenylalanine is a large, neutral amino acid which moves across the blood-brain barrier (BBB) via the large neutral amino acid transporter (LNAAT). Excessive phenylalanine in the blood saturates the transporter. Thus, excessive levels of phenylalanine significantly decrease the levels of other LNAAs in the brain. But since these amino acids are required for protein and neurotransmitter synthesis, phenylalanine accumulation disrupts brain development, leading to mental retardation. Copyright Copyright ©2005-2009 Genome Alberta (Reference to original publication: Wishart DS, Knox C, Guo AC, et al. HMDB: a knowledgebase for the human metabolome. Nucleic Acids Res. 2009 37(Database issue):D603-610.) Source: Human Metabolome Database, Human Metabolome Database

LOINC Names Get Info

Fully-Specified Name
Phenyllactate:SCnc:Pt:Ser/Plas:Qn:
Long Common Name
Phenyllactate [Moles/volume] in Serum or Plasma
Short Name
Phenyllactate SerPl-sCnc
Display Name
Phenyllactate [Moles/Vol]
Consumer Name Alpha Get Info
Phenyllactate, Blood

Part Model Get Info

  • Component
    Phenyllactate
    LP18451-2
    • Analyte
      Phenyllactate
      LP18451-2
      • Component Numerator
        Phenyllactate
        LP18451-2
        • Component Numerator Core
          Phenyllactate
          LP18451-2
        • Component Numerator Core Suffix
          NULL
           
      • Component Denominator
        NULL
         
        • Component Denominator Core
          NULL
           
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    SCnc
    LP6860-3
  • Time
    Pt
    LP6960-1
  • System
    Ser/Plas
    LP7576-4
    • System Core
      Ser/Plas
      LP7576-4
    • Super System
      NULL
       
  • Scale
    Qn
    LP7753-9
  • Method
    NULL
     

Basic Attributes

Class
CHEM
Type
Laboratory
First Released
Version 2.42
Last Updated
Version 2.42 (MIN)
Order vs. Observation
Both

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)Fenyllaktát:Látková koncentrace:Časový bod:Sérum/plazma:Kvantitativní:
el-GRGreek (Greece)Φαινυλακτικό οξύ:SCnc:Pt:Ορός/Πλάσμα:Qn:
Synonyms: CHEM Pt Qn SCnc Ορός Ορός/Πλάσμα Πλάσμα Φαινυλακτικό οξύ
es-MXSpanish (Mexico)Fenilactato:Concentración de sustancias:Punto temporal:Suero o Plasma:Cuantitativo:
es-ESSpanish (Spain)Fenilactato:Concentración de sustancia:Punto temporal:Suero o Plasma:Qn:
Synonyms: Cuantitativo
et-EEEstonian (Estonia)Fenüüllaktaat:SCnc:Pt:S/P:Qn:
Synonyms: Aine kontsentratsioon Juhuslik Kvantitatiivne Plasma Seerum Seerum või plasma
fr-CAFrench (Canada)Phényllactate:Concentration de substance:Temps ponctuel:Sérum/Plasma:Quantitatif:
fr-FRFrench (France)3-phényllactate:Moles/Volume:Ponctuel:Sérum/Plasma:Numérique:
fr-BEFrench (Belgium)Phényllactate:Concentration de substance:Temps ponctuel:Sérum/Plasma:Quantitatif:
it-ITItalian (Italy)Fenillattato:SCnc:Pt:Siero/Plasma:Qn:
Synonyms: Chimica Concentrazione di Sostanza Plasma Punto nel tempo (episodio) Siero Siero o Plasma
nl-NLDutch (Netherlands)fenyllactaat:mol/volume:moment:serum of plasma:kwantitatief:
pl-PLPolish (Poland)Fenylomleczan:stężenie molowe:punkt w czasie:surowica lub osocze:ilościowy:
ru-RURussian (Russian Federation)Фениллактат:МолКонц:ТчкВрм:Сыв/Плаз:Колич:
Synonyms: Количественный Молярность;Молярная объёмная концентрация Плазма Сыворотка Сыворотка или Плазма Точка во времени;Момент
tr-TRTurkish (Turkey)Fenillaktat:SubKons:Zmlı:Ser/Plaz:Kant:
zh-CNChinese (China)苯乳酸:物质的量浓度:时间点:血清/血浆:定量型:
Synonyms: 克分子浓度;克分子浓度(单位体积);摩尔浓度;摩尔浓度(单位体积);物质的量浓度(单位体积) 化学;化学检验项目;化学检验项目类;化学类;化学试验;非刺激耐受型化学检验项目;非刺激耐受型化学检验项目类;非刺激耐受型化学试验;非刺激耐受型化学试验类 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 时刻;随机;随意;瞬间 血清或血浆

Example Units

UnitSource
umol/LExample UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=72437-7