Version 2.78

Term Description

Wilm's tumor (WT1) gene expression is calculated by measuring the copy numbers of transcripts within exon 1 and 2 of the WTI gene compared to transcripts from a control gene. The WT1 gene expression is used as a specific molecular marker to improve diagnosis, prognosis and follow-up of adult acute myeloid leukemia (AML) patients. Early decreased expression of WT1 copy number in peripheral blood predicts better outcome for AML patients PMID: 20107153. This code is based on, but not limited in use to, the submitter's package insert, Ipsogen's ProfileQuant® kit. This kit uses real-time quantitative PCR to quantify WT1 gene expression relative to ABL1 control gene.
Source: Regenstrief LOINC

Part Description

LP157474-0   WT1 gene exon 1+2 transcript
WT1 gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an important role in cell growth and differentiation. Initially isolated as the gene responsible for Wilms' tumor, it is implicated in several cancers. WT1 is expressed at high levels in most acute myeloid leukemias, AML (and in ALL too), making it a tumor marker for leukemic blasts. It is also expressed at high levels in solid tumors. The WT1 gene expression is used as a specific molecular marker to improve diagnosis, prognosis and follow-up of adult acute myeloid leukemia (AML) patients. Early decreased expression of WT1 copy number in peripheral blood predicts better outcome for AML patients. Regarding mutations, multiple transcript variants, resulting from alternative splicing at two coding exons, have been well characterized. There is also evidence for the use of non-AUG (CUG) translation initiation site upstream of, and in-frame with the first AUG, leading to additional isoforms. Authors of PMID: 7926762 also provide evidence that WT1 mRNA undergoes RNA editing in human and rat, and that this process is tissue-restricted and developmentally regulated. Source: Regenstrief LOINC

Fully-Specified Name

Component
WT1 gene exon 1+2 transcript/control transcript
Property
NRto
Time
Pt
System
Bld/Tiss
Scale
Qn
Method
Molgen

Additional Names

Long Common Name
WT1 gene exon 1+2 transcript/control transcript [# Ratio] in Blood or Tissue by Molecular genetics method
Short Name
WT1 ex 1+2/control Bld/T
Display Name
WT1 gene exon 1+2 transcript/control transcript Molgen (Bld/Tiss) [# ratio]
Consumer Name Alpha Get Info
WT1 gene Exon 1+2 transcript/control Transcript, Blood or tissue specimen

Basic Attributes

Class
MOLPATH.MUT
Type
Laboratory
First Released
Version 2.42
Last Updated
Version 2.42
Order vs. Observation
Both

Formula (Readable)

Normalized copy number (NCN) = [WT1 copy number/ABL1 copy number] x 10000

Language Variants Get Info

Tag Language Translation
de-AT German (Austria) Synonyms: WT1 Gen Transkript qn.
es-ES Spanish (Spain) Transcrito del gen WT1 exón 1+2/transcrito control:Relación de número:Punto temporal:Sangre o tejido:Qn:Genética molecular
Synonyms: Cuantitativo
es-MX Spanish (Mexico) Transcripción del exón 1 + 2 del gen WT1 / transcripción de control:Proporción numérica:Punto temporal:Sangre o tejido:Cuantitativo:Genética molecular
fr-FR French (France) WT1 gène exons 1+2 transcrits/transcrit de référence:Nombre/Nombre:Ponctuel:Sang/Tissu:Numérique:Biologie moléculaire
it-IT Italian (Italy) WT1, gene, esoni 1+2 trascritti/trascritto di controllo:NRto:Pt:Sangue/Tess:Qn:Molgen
Synonyms: Esoni 1+2 trascritti del gene WT1 Gene WT1 Genetica molecolare Mutazione genica Patologia molecolare Punto nel tempo (episodio) Rapporto numerico Sangue Sangue o Tessuto Tessuto & Strisci
nl-NL Dutch (Netherlands) WT1-gen exon 1+2 transcript/controle transcript:aantalsverhouding:moment:bloed of weefsel:kwantitatief:moleculair genetisch onderzoek
Synonyms: molgen WT1 gen
pt-BR Portuguese (Brazil) WT1 gene exon 1+2 transcrição/transcrição controle::Pt:Sg/Tecido:Qn:Genética molecular
ru-RU Russian (Russian Federation) WT1 ген экзон 1+2 транскрипт/контрольный транскрипт:КолОтн:ТчкВрм:Кр/Тк:Колич:МолГен
Synonyms: Количественное отношение Количественный Кровь Кровь или Ткань Ткань и мазки Точка во времени;Момент
tr-TR Turkish (Turkey) WT1 geni ekzon 1+2 transkript/kontrol transkripti:SayOr:Zmlı:Kan/Dk:Kant:Molgen
zh-CN Chinese (China) WT1 基因外显子 1+2 转录物/对照转录物:计数型比率:时间点:全血/组织:定量型:分子遗传学类实验室方法
Synonyms: Ⅰ Ⅱ GUD GUD;Nephroblastoma;Wilms 瘤;Wilms 肿瘤 1;威尔姆氏肿瘤 1;肾母细胞瘤;肾母细胞瘤 1;肾胚细胞肿瘤;肾胚胎瘤;肾胚胎瘤 1;胚胎性恶性混合瘤 I II WAGR Wilms 瘤 1 WIT-2 WT1 基因外显子 1+2 转录物（转录本、转录产物、转录子、转录）;WT1 基因外显子 1+2 转录;WT1 基因外显子 1+2 转录物 全血或组织;血液/组织;血液或组织 分子病理学.基因突变;分子病理学.突变;分子病理学试验.基因突变;分子病理学试验.突变;分子病理学试验类.突变;基因突变;突变 分子病理学;分子病理学试验 分子遗传学;分子遗传学方法;分子遗传学类方法;分子遗传学类检验方法;包括 RFL、PCR 及其他方法在内，用于在分子基础上检测遗传属性的方法的大类;聚合酶链反应;聚合酶链式反应 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 同一样本内两种不同实体的数量之比;数量型比;数量型比值;数量型比率;数量或计数型比;数量或计数型比值;计数型比;计数型比值;数量或计数型比率 对照转录物（转录本、转录产物、转录子、转录）;对照基因转录本;控制转录本 时刻;随机;随意;瞬间 未作说明的组织;组织;组织 & 涂片 肾母细胞瘤 1 肾母细胞瘤 1（Wilms tumor 1，WT1） 肾胚胎瘤 1 血;血液 遗传基因;遗传因子;吉恩;生物基因

Example Units

Unit Source
% Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
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