Macroprolactin [Presence] in Serum or Plasma
Monomeric prolactin is the most common form of circulating prolactin. Prolactin also has several isoforms, including the dimeric form ("big-prolactin") that has a molecular weight of ~50 kD and polymeric form ("big-big prolactin") that has a molecular weight of ~ 150 kD). Big-big prolactin, known as macroprolactin, and big prolactin are formed in the circulation after secretion of prolactin from the pituitary. They have a longer half-life than monomeric prolactin are not biologically active. However, typical prolactin assays do not differentiate between the different forms of prolactin, and the presence of big and big-big prolactin can lead to a false diagnosis of hyperprolactinemia. Methods such as PEG precipitation can separate macroprolactin and big prolactin from monomeric prolactin in order to obtain a more accurate measurement of biologically active prolactin, and chromatography can be used to further characterize the isoforms if necessary. [PMCID: PMC3719302] Source: Regenstrief LOINC,
- Short Name
- Macroprolactin SerPl Ql
- Display Name
- Macroprolactin Ql
- Consumer Name Alpha Get Info
- Macroprolactin, Blood
Example Answer List: LL2010-8Source: Estonian Society of Laboratory Medicine
|PositiveCopyright http://snomed.info/sct ID:10828004 Positive (qualifier value)||LA6576-8|
|NegativeCopyright http://snomed.info/sct ID:260385009 Negative (qualifier value)||LA6577-6|
- First Released
- Version 2.42
- Last Updated
- Version 2.56
- Change Reason
- The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
- Order vs. Observation
Language Variants Get Info
Synonyms: Järgarvuline Juhuslik Plasma Seerum Seerum või plasma
Synonyms: Chimica Plasma Presenza o Soglia Punto nel tempo (episodio) Siero Siero o Plasma
|ru-RU||Russian (Russian Federation)||Макропролактин:
Synonyms: Плазма Порядковый Сыворотка Сыворотка или Плазма Точка во времени;
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