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Part Description

LP157497-1   CYP3A5 gene.c.6986A>G(*3)
Many drugs are metabolized by members of the cytochrome P450 CYP3A subfamily, which present considerable variation in gene expression. CYP3A4, CYP3A5, CYP3A7 and CYP3A43 genes are included in the 231-kb CYP3A locus. Several single nucleaotide polymorphisms (SNPs) with the CYP3A5 are associated with absence of CYP3A5 expression in the liver. The CYP3A5*1 allele (A6986) appears to be the main allele associated with CYP3A5 expression and activity. Individuals with a CYP3A5*1 allele may show more rapid than average metabolism of CYP3A substrates. Carriers of the mutation CYP3A5*3 (A6986G) appear not to express the enzyme due to the creation of a cryptic splice site. Since CYP3A5 expression in the liver is likely to be a useful predictor of metabolism of a variety of drugs, PCR-based assays are performed to identify a patient's genotype for the CYP3A5*1 and CYP3A5*3 alleles. Source: Regenstrief LOINC, PMID: 12814460

LOINC Names Get Info

Fully-Specified Name
CYP3A5 gene.c.6986A>G(*3):PrThr:Pt:Bld/Tiss:Ord:Molgen
Long Common Name
CYP3A5 gene c.6986A>G(*3) [Presence] in Blood or Tissue by Molecular genetics method
Short Name
CYP3A5*3 Bld/T Ql
Display Name
CYP3A5 gene c.6986A>G(*3) Molgen Ql (Bld/Tiss)
Consumer Name Alpha Get Info
CYP3A5 gene c.6986A>G(*3), Blood or tissue specimen

Part Model Get Info

  • Component
    CYP3A5 gene.c.6986A>G(*3)
    LP157497-1
    • Analyte
      CYP3A5 gene.c.6986A>G(*3)
      LP157497-1
      • Component Numerator
        CYP3A5 gene.c.6986A>G(*3)
        LP157497-1
        • Component Numerator Core
          CYP3A5 gene.c.6986A>G(*3)
          LP157497-1
        • Component Numerator Core Suffix
          NULL
           
      • Component Denominator
        NULL
         
        • Component Denominator Core
          NULL
           
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    PrThr
    LP217195-9
  • Time
    Pt
    LP6960-1
  • System
    Bld/Tiss
    LP7061-7
    • System Core
      Bld/Tiss
      LP7061-7
    • Super System
      NULL
       
  • Scale
    Ord
    LP7751-3
  • Method
    Molgen
    LP6404-0

Example Answer List: LL2014-0

Source: Estonian Society of Laboratory Medicine
AnswerCodeScoreAnswer ID
Wild typeLA9658-1
HeterozygousLA6706-1
HomozygousLA6705-3

Basic Attributes

Class
MOLPATH.PHARMG
Type
Laboratory
First Released
Version 2.42
Last Updated
Version 2.67 (MIN)
Change Reason
Release 2.67: CLASS: Updated to MOLPATH.PHARMG, the more representative LOINC Class for this concept.; Previous Releases: The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation
Both

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)Gen CYP3A5 c.6986A>G(*3):Přítomnost nebo práh:Časový bod:Krev/tkáň:Ordinální:Molekulární genetika
el-GRGreek (Greece)Γονίδιο CYP3A5 c.6986A>G(*3):PrThr:Pt:Αίμα/Ιστός:Ord:Μοριακή γενετική
Synonyms: C G MOLPATH MOLPATH.PHARMG Ord PrThr Pt Αίμα Αίμα/Ιστός Γονίδιο Γονίδιο CYP3A5 c.6986A>G(*3) Ιστός Μοριακή γενετική
es-ESSpanish (Spain)gen CYP3A5.c.6986A>G(*3):PrThr:Punto temporal:Sangre o tejido:Ord:Genética molecular
es-MXSpanish (Mexico)Gen CYP3A5 c.6986A> G (* 3):Presencia o umbral:Punto temporal:Sangre o tejido:Ordinal:Genética molecular
fr-FRFrench (France)CYP3A5 gène mutation c.6986A>G(*3):Présence/Seuil:Ponctuel:Sang/Tissu:Qualitatif:Biologie moléculaire
it-ITItalian (Italy)CYP3A5 gene.c.6986A>G(*3):PrThr:Pt:Sangue/Tess:Ord:Molgen
Synonyms: Farmacogenomica Gene CYP3A5 Genetica molecolare Patologia molecolare Presenza o Soglia Punto nel tempo (episodio) Sangue Sangue o Tessuto Tessuto & Strisci
nl-NLDutch (Netherlands)CYP3A5-gen.c.6986A>G(*3):aanwezigheid:moment:bloed of weefsel:ordinaal:moleculair genetisch onderzoek
Synonyms: molgen
pl-PLPolish (Poland)CYP3A5 gen c.6986A>G(*3):granica wykrywalności:punkt w czasie:krew lub tkanka:uporządkowany:genetyka molekularna
Synonyms: diagnostyka molekularna Gen CYP3A5 c.6986A>G(*3)
ru-RURussian (Russian Federation)CYP3A5 ген.c.6986A>G(*3):PrThr:ТчкВрм:Кр/Тк:Пор:МолГен
Synonyms: Кровь Кровь или Ткань Порядковый Ткань и мазки Точка во времени;Момент
tr-TRTurkish (Turkey)CYP3A5 geni.c.6986A>G(*3):MevcEşik:Zmlı:Kan/Dk:Srl:Molgen
Synonyms: Mevcut
zh-CNChinese (China)CYP3A5 基因.c.6986A>G(*3):存在情况或阈值:时间点:全血/组织:序数型:分子遗传学类实验室方法
Synonyms: Ⅲ C 型;丙;丙型 EC 1.14.14.1;细胞色素 P450 家族 3 亚家族 A 成员 5;细胞色素 P450, 亚家族 IIIA (硝苯吡啶氧化酶), 多肽 5;细胞色素 P450, 家族 3, 亚家族 A, 多肽 5;细胞色素 P450 HLp2;细胞色素 P450-PCN3;Cytochrome P450 Family 3 Subfamily A Member 5;Cytochrome P450, Subfamily IIIA (Niphedipine Oxidase), Polypeptide 5 G 型 III 三 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 全血或组织;血液/组织;血液或组织 分子病理学;分子病理学试验 分子遗传学;分子遗传学方法;分子遗传学类方法;分子遗传学类检验方法;包括 RFL、PCR 及其他方法在内，用于在分子基础上检测遗传属性的方法的大类;聚合酶链反应;聚合酶链式反应 叁 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值） 时刻;随机;随意;瞬间 未作说明的组织;组织;组织 & 涂片 细胞色素 P450, 家族 3, 亚家族 A, 多肽 5;cytochrome P450, family 3, subfamily A, polypeptide 5 血;血液 遗传基因;遗传因子;吉恩;生物基因

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=72697-6