Version 2.78

Description

Many drugs are metabolized by members of the cytochrome P450 CYP3A subfamily, which present considerable variation in gene expression. CYP3A4, CYP3A5, CYP3A7 and CYP3A43 genes are included in the 231-kb CYP3A locus. Several single nucleaotide polymorphisms (SNPs) with the CYP3A5 are associated with absence of CYP3A5 expression in the liver. The CYP3A5*1 allele (A6986) appears to be the main allele associated with CYP3A5 expression and activity. Individuals with a CYP3A5*1 allele may show more rapid than average metabolism of CYP3A substrates. Carriers of the mutation CYP3A5*3 (A6986G) appear not to express the enzyme due to the creation of a cryptic splice site. Since CYP3A5 expression in the liver is likely to be a useful predictor of metabolism of a variety of drugs, PCR-based assays are performed to identify a patient's genotype for the CYP3A5*1 and CYP3A5*3 alleles. Source: Regenstrief LOINC, PMID: 12814460

Basic Part Properties

Part Display Name
CYP3A5 gene c.6986A>G(*3)
Part Type
Component (Describes the core component or analyte measured)
Created On
2012-10-01
Construct for LOINC Short Name
CYP3A5*3

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=LP157497-1

Language Variants Get Info

Tag Language Translation
zh-CN Chinese (China) CYP3A5 基因.c.6986A>G(*3)
Synonyms: 细胞色素 P450, 家族 3, 亚家族 A, 多肽 5;cytochrome P450, family 3, subfamily A, polypeptide 5
es-ES Spanish (Spain) gen CYP3A5.c.6986A>G(*3)
it-IT Italian (Italy) CYP3A5 gene.c.6986A>G(*3)
tr-TR Turkish (Turkey) CYP3A5 geni.c.6986A>G(*3)
ru-RU Russian (Russian Federation) CYP3A5 ген.c.6986A>G(*3)
nl-NL Dutch (Netherlands) CYP3A5-gen.c.6986A>G(*3)