72726-3
t(4;14)(p16;q32)(FGFR3,IGH) fusion transcript [Identifier] in Blood or Tissue by FISH Nominal
Active
Term Description
Labs may report the X number of cells that have the translocation, t(4;14)(p16;q32), out of Y number of cells (e.g. 80 out of 100 cells, or 80%). Results are typically reported in ISCN (International System for Human Cytogenetic Nomenclature) format.
Source: Regenstrief LOINC
Part Descriptions
LP157496-3 t(4;14)(p16;q32)(FGFR3,IGH)
The t(4;14)(p16;q32)(FGFR3,IGH) is detected by FISH and PCR methods, but poorly analyzed by conventional cytogenetic methods (e.g. karyotyping). The breakpoints on chromosome 4 occur within a 113-kb gene cluster region involving the fibroblast growth factor receptor 3 (FGFR3) gene. The fusion results in overexpression and activation of FGFR3, which causes oncogenic signal enhancing cell proliferation and survival. The t(4;14) translocation provides important prognostic information in patients with plasma cell myeloma. It is often associated with poor survival and poor response to chemotherapy.
Source: Regenstrief LOINC
LP62864-1 FISH
FISH (fluorescence in situ hybridization) is a cytogenetic technique used to detect and localize the presence or absence of specific DNA sequences on chromosomes. FISH uses fluorescent probes that bind to only those parts of the chromosome with which they show a high degree of sequence similarity. Fluorescence microscopy can be used to find out where the fluorescent probe bound to the chromosomes. FISH is often used for finding specific features in DNA for use in genetic counseling, medicine, and species identification. FISH can also be used to detect and localize specific mRNAs within tissue samples. In this context, it can help define the spatial-temporal patterns of gene expression within cells and tissues.
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Source: Wikipedia, FISH
Fully-Specified Name
- Component
- t(4;14)(p16;q32)(FGFR3,IGH) fusion transcript
- Property
- Prid
- Time
- Pt
- System
- Bld/Tiss
- Scale
- Nom
- Method
- FISH
Additional Names
- Short Name
- t(4;14)(FGFR3,IGH) Bld/T FISH
- Display Name
- t(4;14)(p16;q32)(FGFR3,IGH) fusion transcript FISH Nom (Bld/Tiss)
- Consumer Name Alpha Get Info
- t(4;14)(p16;q32)(FGFR3,IGH) fusion transcript analysis, Blood or tissue specimen
Example Answer List: LL2356-5
Source: Estonian Society of Laboratory Medicine| Answer | Code | Score | Answer ID |
|---|---|---|---|
| (4p16,14q32)x2[100] | LA19546-3 | ||
| t(4;14)(p16;q32)[x80]/(4p16,14q32)x2[20] | LA19545-5 |
Basic Attributes
- Class
- MOLPATH.TRNLOC
- Type
- Laboratory
- First Released
- Version 2.42
- Last Updated
- Version 2.73
- Order vs. Observation
- Both
- Common Test Rank Get Info
- 16312
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| es-ES | Spanish (Spain) | t(4; |
| es-MX | Spanish (Mexico) | t (4; |
| fr-FR | French (France) | t(4; |
| fr-CA | French (Canada) | t(4; |
| it-IT | Italian (Italy) | t(4; Synonyms: Ibridazione in situ fluorescente (FISH) Patologia molecolare Presenza o Identità Punto nel tempo (episodio) Sangue Sangue o Tessuto Tessuto & |
| nl-NL | Dutch (Netherlands) | t(4; |
| pl-PL | Polish (Poland) | t (4; Synonyms: Translokacja (4; |
| pt-BR | Portuguese (Brazil) | t(4; |
| tr-TR | Turkish (Turkey) | t(4; |
| zh-CN | Chinese (China) | t(4; Synonyms: Fluorescent in situ hybridization; |
LOINC Terminology Service (API) using HL7® FHIR® Get Info
Requests to this service require a free LOINC username and password. Below is a sample of the possible capabilities. See the LOINC Terminology Service documentation for more information.
- CodeSystem lookup
- https:
//fhir.loinc.org/CodeSystem/$lookup?system=http: //loinc.org&code=72726-3
LOINC Copyright
Copyright © 2024 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright