Version 2.80

Term Description

FISH techniques, such as whole chromosome painting (WCP) using a mixture of probes, is performed to identify a rare dicentric chromosome abnormality, dic(9;20)(p11-13;q11). This abnormality occurs in leukemia patients and may be specifically associated with acute lymphoblastic leukemia (ALL). The presence of the aberration is important for coordinating adequate therapy. The submitter's lab reports the X number of cells that have the probe deletion out of Y number of cells, which is usually 100% when present. Results are typically reported in ISCN (International System for Human Cytogenetic Nomenclature) format.

Part Descriptions

LP157492-2   dic(9;20)(p11-13;q11)(wcp9+,wcp20+)
A recurring chromosome aberration resulting in a dicentric chromosome, dic(9;20)(p11~13;q11), occurs in patients with acute lymphocytic leukemia (ALL), specifically B-cell precursor. Dic(9;20) occurs due to a breakpoint within the PAX5 gene on 9p, which fuses with one of a number of different genes on 20q. This usually results in loss of 9p and 20q material. It can occur as part of a complex karyotype or an individual cytogenetic abnormality. It is known to occur in the presence of the BCR-ABL1, t(9;22)(q34.1;q11), and ETV6-RUNX1, t(12;21)(p13;q22.3), fusion genes. Relapses after treatment are quite common. However, post-relapse treatment of many patients is successful. Source: Regenstrief LOINC

LP62864-1   FISH
FISH (fluorescence in situ hybridization) is a cytogenetic technique used to detect and localize the presence or absence of specific DNA sequences on chromosomes. FISH uses fluorescent probes that bind to only those parts of the chromosome with which they show a high degree of sequence similarity. Fluorescence microscopy can be used to find out where the fluorescent probe bound to the chromosomes. FISH is often used for finding specific features in DNA for use in genetic counseling, medicine, and species identification. FISH can also be used to detect and localize specific mRNAs within tissue samples. In this context, it can help define the spatial-temporal patterns of gene expression within cells and tissues. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia , FISH

Fully-Specified Name

Component
dic(9;20)(p11-13;q11)(wcp9+,wcp20+)
Property
Prid
Time
Pt
System
Bld/Tiss
Scale
Nom
Method
FISH

Additional Names

Long Common Name
dic(9;20)(p11-13;q11)(wcp9+,wcp20+) [Identifier] in Blood or Tissue by FISH Nominal
Short Name
dic(9;20)(wcp9+,wcp20+) Bld/T FISH
Display Name
dic(9;20)(p11-13;q11)(wcp9+,wcp20+) FISH Nom (Bld/Tiss)
Consumer Name Alpha Get Info
dic(9;20)(p11-13;q11)(wcp9+,wcp20+), Blood or tissue specimen

Example Answer List: LL2360-7

Source: Estonian Society of Laboratory Medicine
Answer Code Score Answer ID
(wcp9,wcp20)x2[100]

Normal result

 LA19547-1
der(9)t(9;20)(p11-13;q11)(wcp9+,wcp20+)

Pathologic result

 LA19548-9

Basic Attributes

Class
MOLPATH
Type
Laboratory
First Released
Version 2.42
Last Updated
Version 2.73 (MIN)
Order vs. Observation
Both
Common Test Rank Get Info
16053

Language Variants Get Info

Tag Language Translation
el-GR Greek (Greece) dic(9;20)(p11-13;q11)(wcp9+,wcp20+):Prid:Pt:Αίμα/Ιστός:Nom:Φθορίζουσα υβριδοποίηση in situ
Synonyms: dic(9;20)(p11-13;q11)(wcp9+,wcp20+) Prid
es-ES Spanish (Spain) dic(9;20)(p11-13;q11)(wcp9+,wcp20+):Presencia o identidad:Punto temporal:Sangre o tejido:Nom:Hibridación in situ fluoresente (FISH)
es-MX Spanish (Mexico) dic (9; 20) (p11-13; q11) (wcp9 +, wcp20 +):Presencia o identidad:Punto temporal:Sangre o tejido:Nominal:Hibridación fluorescente in situ (FISH)
fr-FR French (France) dic(9;20)(p11-13;q11)(wcp9+,wcp20+):Identification:Ponctuel:Sang/Tissu:Résultat nominal:FISH
it-IT Italian (Italy) dic(9;20)(p11-13;q11)(wcp9+,wcp20+):Prid:Pt:Sangue/Tess:Nom:FISH
Synonyms: Ibridazione in situ fluorescente (FISH) Patologia molecolare Presenza o Identità Punto nel tempo (episodio) Sangue Sangue o Tessuto Tessuto & Strisci
nl-NL Dutch (Netherlands) dic(9;20)(p11-13;q11)(wcp9+,wcp20+):identificator:moment:bloed of weefsel:nominaal:FISH
pt-BR Portuguese (Brazil) dic(9;20)(p11-13;q11)(wcp9+,wcp20+):Ident:Pt:Sg/Tecido:Nom:FISH
tr-TR Turkish (Turkey) dic(9;20)(p11-13;q11)(wcp9+,wcp20+):MevcKimlik:Zmlı:Kan/Dk:Snf:FISH
zh-CN Chinese (China) dic(9;20)(p11-13;q11)(wcp9+,wcp20+):存在与否或特征标识:时间点:全血/组织:名义型:FISH
Synonyms: dicentric chromosome;双着丝粒染色体 Fluorescent in situ hybridization;荧光原位杂交 全血或组织;血液/组织;血液或组织 分子病理学;分子病理学试验 分类型应答;分类型结果;名义性;名称型;名词型;名词性;标称性;没有自然次序的名义型或分类型应答 存在;存在与否;特征标识;身份;身份标识 时刻;随机;随意;瞬间 未作说明的组织;组织;组织 & 涂片 血;血液

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=72827-9