72877-4

Deprecated CYP2B6 gene drug metabolism analysis overall interpretation [Interpretation] in Blood, Tissue or Saliva Qualitative by Molecular genetics method

Deprecated

Status Information

Status: DEPRECATED
Reason: Duplicate

Map-To	Long Common Name	Mapping Guidance
79720-9	CYP2B6 gene product metabolic activity interpretation in Blood or Tissue Qualitative by Molecular genetics method

Term Description

Overall predicted phenotype for drug metabolism for all markers and/or individual CYP2B6 alleles identified in a patient. The predicted phenotypes are derived from reference literature.

Part Descriptions

LP157451-8 CYP2B6 gene
CYP2B6 gene encodes a member of the cytochrome P450 enzymes, which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. CYP2B6, along with CYP2A6, is involved with metabolizing nicotine as well as many other substances. Transcript variants for the CYP2B6 gene have been described, including 415A>G (*8), 516G>T (*9), 983T>C (*16), and 1459C>T(*5), and are associated with altered drug metabolism. CYP2B6 gene is found in a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, CYP2B6 (Wikipedia)

LP157451-8 CYP2B6 gene
The CYP2B6 gene (cytochrome P450, family 2, subfamily B, polypeptide 6) [HGNC Gene ID:2615] is located on chromosome 19q13.2. This gene, CYP2B6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize some xenobiotics, such as the anti-cancer drugs cyclophosphamide and ifosphamide. Transcript variants for this gene have been described; however, it has not been resolved whether these transcripts are in fact produced by this gene or by a closely related pseudogene, CYP2B7. Both the gene and the pseudogene are located in the middle of a CYP2A pseudogene found in a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. [provided by RefSeq, Jul 2008] [NCBI Gene ID:1555] Source: National Center for Biotechnology Information (NCBI) Gene

LOINC Names Get Info

Fully-Specified Name: CYP2B6 gene drug metabolism analysis overall interpretation:Imp:Pt:Bld/Tiss/Sal:Ord:Molgen
Long Common Name: Deprecated CYP2B6 gene drug metabolism analysis overall interpretation [Interpretation] in Blood, Tissue or Saliva Qualitative by Molecular genetics method
Short Name: Deprecated CYP2B6 drg metab interp Bld/T/S-Imp
Display Name: CYP2B6 gene drug metabolism analysis overall interpretation Molgen Ql (Bld/Tiss/Sal) [Interp]
Consumer Name Alpha Get Info: CYP2B6 gene drug metabolism interpretation

Part Model Get Info

Component
CYP2B6 gene drug metabolism analysis overall interpretation
LP228236-8
- Analyte
  CYP2B6 gene drug metabolism analysis overall interpretation
  LP228236-8
  - Component Numerator
    CYP2B6 gene drug metabolism analysis overall interpretation
    LP228236-8
    - Component Numerator Core
      CYP2B6 gene
      LP157451-8
    - Component Numerator Core Suffix
      drug metabolism analysis overall interpretation
      LP157533-3
  - Component Denominator
    NULL
    - Component Denominator Core
      NULL
    - Component Denominator Core Suffix
      NULL
- Challenge
  NULL
- Adjustment
  NULL
- Count
  NULL
Property
Imp
LP6819-9
Time
Pt
LP6960-1
- Time Core
  Pt
  LP6960-1
- Time Modifier
  NULL
System
Bld/Tiss/Sal
LP171889-1
- System Core
  Bld/Tiss/Sal
  LP171889-1
- Super System
  NULL
Scale
Ord
LP7751-3
Method
Molgen
LP6404-0

Example Answer List: LL605-7

Source: Regenstrief LOINC

Answer	Code	Score	Answer ID
Ultrarapid metabolizer			LA10315-2
Extensive metabolizer			LA10316-0
Intermediate metabolizer			LA10317-8
Poor metabolizer			LA9657-3
InconclusiveCopyright http://snomed.info/sct ID:419984006 Inconclusive (qualifier value)			LA9663-1
Failure			LA9664-9

Basic Attributes

Class: MOLPATH.MUT
Type: Laboratory
First Released: Version 2.44
Last Updated: Version 2.67 (DEL)
Change Reason: Corrected Scale from "Nom" to "Ord" since results are ordinal.
Order vs. Observation: Observation

Language Variants Get Info

Tag	Language	Translation
cs-CZ	Czech (Czechia)	Gen CYP2B6 analýza lékového metabolismu celková interpretace:Interpretace:Časový bod:Krev/tkáň/sliny:Ordinální:Molekulární genetika
el-GR	Greek (Greece)	Γονίδιο CYP2B6 γενική ερμηνεία ανάλυσης μεταβολισμού φαρμάκου:Imp:Pt:Αίμα/Ιστός/Σίελος:Ord:Μοριακή γενετική Synonyms: Imp MOLPATH MOLPATH.MUT Ord Pt Αίμα Αίμα/Ιστός Αίμα/Ιστός/Σίελος γενική ερμηνεία ανάλυσης μεταβολισμού φαρμάκου Γονίδιο Γονίδιο CYP2B6 Ερμηνεία Ιστός Μοριακή γενετική Φάρμακο
es-ES	Spanish (Spain)	gen CYP2B6 Interpretación total del metabolismo de drogas:Impresión/interpretación del estudio:Punto temporal:Bld/Tej/Sal:Ord:Genética molecular
es-MX	Spanish (Mexico)	Interpretación general del análisis del metabolismo de fármacos del gen CYP2B6:Impresión / interpretación del estudio:Punto temporal:Sangre, tejido o saliva:Ordinal:Genética molecular
fr-FR	French (France)	CYP2B6 gène métabolisme des médicaments interprétation globale:Interprétation:Ponctuel:Sang/Tissu/Salive:Qualitatif:Biologie moléculaire
it-IT	Italian (Italy)	CYP2B6, gene, farmaci, interpretazione complessiva analisi metabolismo:Imp:Pt:Sangue/Tessuto/Saliva,Sangue, Tessuto o Saliva:Ord:Molgen Synonyms: Gene CYP2B6 Genetica molecolare Impressione/interpretazione di studio Interpretazione complessiva di analisi del metabol Mutazione genica Patologia molecolare Punto nel tempo (episodio) Sangue Sangue o Tessuto Tessuto & Strisci
pl-PL	Polish (Poland)	CYP2B6 gen ogólna interpretacja analizy metabolizmu leku:ocena:punkt w czasie:krew/Tkanka/Ślina:uporządkowany:genetyka molekularna Synonyms: diagnostyka molekularna Gen CYP2B6
ru-RU	Russian (Russian Federation)	CYP2B6 ген наркотик метаболизм анализ общая интерпретация:Впчт:ТчкВрм:Кр/Тк/Слюна:Пор:МолГен Synonyms: Впечатление/интерпретация исследования Кровь Кровь или Ткань Кровь, Ткань или Слюна лекарства метаболизма анализ общая интерпретация Наркотик Порядковый Ткань и мазки Точка во времени;Момент
tr-TR	Turkish (Turkey)	CYP2B6 geni ilaç metabolizması analizi tüm değerlendirilme:İzlnm:Zmlı:Kan/Doku/Tükrük:Srl:Molgen Synonyms: KISALTILMIŞINA BAK
zh-CN	Chinese (China)	CYP2B6 基因药物代谢分析总体解释:印象:时间点:全血/组织/唾液:序数型:分子遗传学类实验室方法 Synonyms: cytochrome P450, family 2, subfamily B, polypeptide 6;细胞色素 P450, 家族 2, 亚家族 B, 多肽 6;CYP2B6 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型全血或组织;血液/组织;血液或组织全血或组织或唾液;血液/组织/唾液;血液或组织或唾液;全血/组织/涎全面;整体;总体情况分子病理学.基因突变;分子病理学.突变;分子病理学试验.基因突变;分子病理学试验.突变;分子病理学试验类.突变;基因突变;突变分子病理学;分子病理学试验分子遗传学;分子遗传学方法;分子遗传学类方法;分子遗传学类检验方法;包括 RFL、PCR 及其他方法在内，用于在分子基础上检测遗传属性的方法的大类;聚合酶链反应;聚合酶链式反应判读;解释说明;说明;释义;阐明印象是一种诊断陈述，始终是对其他某种观察指标的解释或抽象（一系列检验项目结果、一幅图像或者整个某位病人），而且几乎总是由某位专业人员产生。;检查印象;检查印象/解释;检查的印象/解释;检查解释;解释;阐释时刻;随机;随意;瞬间未作说明的组织;组织;组织 & 涂片毒品毒品;麻醉药;麻醉品;麻药;兴奋剂;药品毒品类药品类药物药物（毒品、麻醉药、麻醉品、麻药、兴奋剂、药品）代谢（新陈代谢）分析总体（整体、宏观、大体、概括）解释（说明、阐释、诠释）药物代谢分析总体解释（整体解释、全面解释）药物类血;血液遗传基因;遗传因子;吉恩;生物基因

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