Version 2.78

Status Information

Status
DEPRECATED
Reason
Duplicate
Map-To Long Common Name Mapping Guidance
79720-9 CYP2B6 gene product metabolic activity interpretation in Blood or Tissue Qualitative by Molecular genetics method

Term Description

Overall predicted phenotype for drug metabolism for all markers and/or individual CYP2B6 alleles identified in a patient. The predicted phenotypes are derived from reference literature.
Source: Regenstrief LOINC

Part Descriptions

LP157451-8   CYP2B6 gene
CYP2B6 gene encodes a member of the cytochrome P450 enzymes, which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. CYP2B6, along with CYP2A6, is involved with metabolizing nicotine as well as many other substances. Transcript variants for the CYP2B6 gene have been described, including 415A>G (*8), 516G>T (*9), 983T>C (*16), and 1459C>T(*5), and are associated with altered drug metabolism. CYP2B6 gene is found in a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, CYP2B6 (Wikipedia)

LP157451-8   CYP2B6 gene
The CYP2B6 gene (cytochrome P450, family 2, subfamily B, polypeptide 6) [HGNC Gene ID:2615] is located on chromosome 19q13.2. This gene, CYP2B6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize some xenobiotics, such as the anti-cancer drugs cyclophosphamide and ifosphamide. Transcript variants for this gene have been described; however, it has not been resolved whether these transcripts are in fact produced by this gene or by a closely related pseudogene, CYP2B7. Both the gene and the pseudogene are located in the middle of a CYP2A pseudogene found in a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. [provided by RefSeq, Jul 2008] [NCBI Gene ID:1555] Source: National Center for Biotechnology Information (NCBI) Gene

Fully-Specified Name

Component
CYP2B6 gene drug metabolism analysis overall interpretation
Property
Imp
Time
Pt
System
Bld/Tiss/Sal
Scale
Ord
Method
Molgen

Additional Names

Short Name
Deprecated CYP2B6 drg metab interp Bld/T/S-Imp
Display Name
CYP2B6 gene drug metabolism analysis overall interpretation Molgen Ql (Bld/Tiss/Sal) [Interp]
Consumer Name Alpha Get Info
CYP2B6 gene drug metabolism interpretation

Example Answer List: LL605-7

Source: Regenstrief LOINC
Answer Code Score Answer ID
Ultrarapid metabolizer LA10315-2
Extensive metabolizer LA10316-0
Intermediate metabolizer LA10317-8
Poor metabolizer LA9657-3
InconclusiveCopyright http://snomed.info/sct ID:419984006 Inconclusive (qualifier value) LA9663-1
Failure LA9664-9

Basic Attributes

Class
MOLPATH.MUT
Type
Laboratory
First Released
Version 2.44
Last Updated
Version 2.67
Change Reason
Corrected Scale from "Nom" to "Ord" since results are ordinal.
Order vs. Observation
Observation

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) gen CYP2B6 Interpretación total del metabolismo de drogas:Impresión/interpretación del estudio:Punto temporal:Bld/Tej/Sal:Ord:Genética molecular
es-MX Spanish (Mexico) Interpretación general del análisis del metabolismo de fármacos del gen CYP2B6:Impresión / interpretación del estudio:Punto temporal:Sangre, tejido o saliva:Ordinal:Genética molecular
fr-FR French (France) CYP2B6 gène métabolisme des médicaments interprétation globale:Interprétation:Ponctuel:Sang/Tissu/Salive:Qualitatif:Biologie moléculaire
it-IT Italian (Italy) CYP2B6, gene, farmaci, interpretazione complessiva analisi metabolismo:Imp:Pt:Sangue/Tessuto/Saliva:Ord:Molgen
Synonyms: Gene CYP2B6 Genetica molecolare Impressione/interpretazione di studio Interpretazione complessiva di analisi del metabol Mutazione genica Patologia molecolare Punto nel tempo (episodio) Sangue Sangue o Tessuto Sangue, Tessuto o Saliva Tessuto & Strisci
pt-BR Portuguese (Brazil) CYP2B6 gene análise do metabolismo de drogas interpretação global::Pt:Sg/Tecido:Nom:Genética molecular
ru-RU Russian (Russian Federation) CYP2B6 ген наркотик метаболизм анализ общая интерпретация:Впчт:ТчкВрм:Кр/Тк/Слюна:Пор:МолГен
Synonyms: Впечатление/интерпретация исследования Кровь Кровь или Ткань Кровь, Ткань или Слюна лекарства метаболизма анализ общая интерпретация Наркотик Порядковый Ткань и мазки Точка во времени;Момент
tr-TR Turkish (Turkey) CYP2B6 geni ilaç metabolizması analizi tüm değerlendirilme:İzlnm:Zmlı:Kan/Doku/Tükrük:Srl:Molgen
Synonyms: KISALTILMIŞINA BAK
zh-CN Chinese (China) CYP2B6 基因 药物代谢分析总体解释:印象:时间点:全血/组织/唾液:序数型:分子遗传学类实验室方法
Synonyms: cytochrome P450, family 2, subfamily B, polypeptide 6;细胞色素 P450, 家族 2, 亚家族 B, 多肽 6;CYP2B6 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 全血或组织;血液/组织;血液或组织 全血或组织或唾液;血液/组织/唾液;血液或组织或唾液;全血/组织/涎 全面;整体;总体情况 分子病理学.基因突变;分子病理学.突变;分子病理学试验.基因突变;分子病理学试验.突变;分子病理学试验类.突变;基因突变;突变 分子病理学;分子病理学试验 分子遗传学;分子遗传学方法;分子遗传学类方法;分子遗传学类检验方法;包括 RFL、PCR 及其他方法在内，用于在分子基础上检测遗传属性的方法的大类;聚合酶链反应;聚合酶链式反应 判读;解释说明;说明;释义;阐明 印象是一种诊断陈述，始终是对其他某种观察指标的解释或抽象（一系列检验项目结果、一幅图像或者整个某位病人），而且几乎总是由某位专业人员产生。;检查印象;检查印象/解释;检查的印象/解释;检查解释;解释;阐释 时刻;随机;随意;瞬间 未作说明的组织;组织;组织 & 涂片 毒品 毒品;麻醉药;麻醉品;麻药;兴奋剂;药品 毒品类 药品类 药物 药物（毒品、麻醉药、麻醉品、麻药、兴奋剂、药品）代谢（新陈代谢）分析总体（整体、宏观、大体、概括）解释（说明、阐释、诠释） 药物代谢分析总体解释（整体解释、全面解释） 药物类 血;血液 遗传基因;遗传因子;吉恩;生物基因

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