LP157451-8
CYP2B6 gene
Active
Descriptions
CYP2B6 gene encodes a member of the cytochrome P450 enzymes, which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. CYP2B6, along with CYP2A6, is involved with metabolizing nicotine as well as many other substances. Transcript variants for the CYP2B6 gene have been described, including 415A>G (*8), 516G>T (*9), 983T>C (*16), and 1459C>T(*5), and are associated with altered drug metabolism. CYP2B6 gene is found in a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, CYP2B6 (Wikipedia)
The CYP2B6 gene (cytochrome P450, family 2, subfamily B, polypeptide 6) [HGNC Gene ID:2615] is located on chromosome 19q13.2. This gene, CYP2B6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize some xenobiotics, such as the anti-cancer drugs cyclophosphamide and ifosphamide. Transcript variants for this gene have been described; however, it has not been resolved whether these transcripts are in fact produced by this gene or by a closely related pseudogene, CYP2B7. Both the gene and the pseudogene are located in the middle of a CYP2A pseudogene found in a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. [provided by RefSeq, Jul 2008] [NCBI Gene ID:1555] Source: National Center for Biotechnology Information (NCBI) Gene
Basic Part Properties
- Part Display Name
- CYP2B6 gene
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2012-09-25
- Construct for LOINC Short Name
- CYP2B6
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | CYP2B6 基因 Synonyms: cytochrome P450, family 2, subfamily B, polypeptide 6; |
| es-ES | Spanish (Spain) | gen CYP2B6 |
| it-IT | Italian (Italy) | CYP2B6, gene Synonyms: Gene CYP2B6 |
| tr-TR | Turkish (Turkey) | CYP2B6 geni |
| ru-RU | Russian (Russian Federation) | CYP2B6 ген |
| nl-NL | Dutch (Netherlands) | CYP2B6-gen |
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