Version 2.78

Part Description

LP417565-1   CYP1A2 gene allele
Genetic screening for abnormal CYP1A2 metabolism is focused on the presence of *1C (-3860G>A), *1F (163C>A) and *1K (-729C>T) genetic polymorphisms. Individuals homozygous for *1F have higher CYP1A2 activity in the presence of CYP1A2 inducers. The *1C and *1K alleles are associated with decreased CYP1A2 activity with intermediate metabolism when 1 allele is present and slow (poor) metabolism when 2 alleles are present. Inducers for CYP1A2 activity include smoking, coffee, omeprazole, insulin. Inhibitors include oral contraceptives. The genotype results may be used to determine a patient's drug dose adjustment. Source: Regenstrief LOINC

Fully-Specified Name

Component
CYP1A2 gene allele
Property
Geno
Time
Pt
System
Bld/Tiss
Scale
Nom
Method
Molgen

Additional Names

Long Common Name
CYP1A2 gene allele [Genotype] in Blood or Tissue by Molecular genetics method Nominal
Short Name
CYP1A2 allele Geno Bld/T
Display Name
CYP1A2 gene allele genotype Molgen (Bld/Tiss)
Consumer Name Alpha Get Info
CYP1A2 gene allele genotype, Blood or tissue specimen

Example Answer List: LL2235-1

Source: Regenstrief LOINC
Answer Code Score Answer ID
CYP1A2 *1C/*1C LA19108-2
CYP1A2 *1F/*1F LA19106-6
CYP1A2 *1F/*1K LA19107-4
CYP1A2 *1K/*1C LA19109-0

Basic Attributes

Class
MOLPATH.PHARMG
Type
Laboratory
First Released
Version 2.44
Last Updated
Version 2.68
Change Reason
Release 2.68: CLASS: Updated to MOLPATH.PHARMG, the more representative LOINC Class for this concept.; COMPONENT: Updated Component to align with the LOINC term naming model for concepts used to report allelic genotypes (e.g. CYP1A2*1C/*1F ), which was the original intent for this term.; Release 2.67: CLASS: Updated to MOLPATH.PHARMG, the more representative LOINC Class for this concept.; Previous Releases: Based on LOINC Committee review (June 2016), "targeted" was added to the Component to clarify that this test is looking for a specific set of mutations as described in the LOINC User Guide under the Molecular Genetics section.
Order vs. Observation
Both

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) Alelo del gen CYP1A2:Genotipo:Punto temporal:Sangre o tejido:Nom:Genética molecular
es-MX Spanish (Mexico) Alelo del gen CYP1A2:Genotipo:Punto temporal:Sangre o tejido:Nominal:Genética molecular
fr-FR French (France) CYP1A2 gène allèle:Génotype:Ponctuel:Sang/Tissu:Résultat nominal:Biologie moléculaire
it-IT Italian (Italy) CYP1A2, gene allele:Geno:Pt:Sangue/Tess:Nom:Molgen
Synonyms: Farmacogenomica Gene CYP1A2 Genetica molecolare Genotipo Patologia molecolare Punto nel tempo (episodio) Sangue Sangue o Tessuto Tessuto & Strisci
nl-NL Dutch (Netherlands) CYP1A2-allel:genotype:moment:bloed of weefsel:nominaal:moleculair genetisch onderzoek
Synonyms: molgen
pt-BR Portuguese (Brazil) CYP1A2 gene análise de mutação:Ident:Pt:Sg/Tecido:Nom:Genética molecular
zh-CN Chinese (China) CYP1A2 基因等位基因:基因型:时间点:全血/组织:名义型:分子遗传学类实验室方法
Synonyms: 全血或组织;血液/组织;血液或组织 分子病理学;分子病理学试验 分子遗传学;分子遗传学方法;分子遗传学类方法;分子遗传学类检验方法;包括 RFL、PCR 及其他方法在内，用于在分子基础上检测遗传属性的方法的大类;聚合酶链反应;聚合酶链式反应 分类型应答;分类型结果;名义性;名称型;名词型;名词性;标称性;没有自然次序的名义型或分类型应答 时刻;随机;随意;瞬间 未作说明的组织;组织;组织 & 涂片 细胞色素P450, 家族1, 亚家族A, 肽2;cytochrome P450, family 1, subfamily A, polypeptide 2;铁离子结合;氧结合;血红素结合;金属离子结合;非特异性单加氧酶 血;血液 遗传基因;遗传因子;吉恩;生物基因

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=72884-0