73695-9

Deprecated HIV reverse transcriptase+protease+integrase gene mutations detected [Identifier]

Deprecated

Status Information

Status: DEPRECATED
Reason: Erroneous
Comment: Both the Component and the System are incorrect. Because the mutations are reported independently for each gene, the "+" in the Component should have been "&", and the System is Plasma, not Isolate.

Map-To	Long Common Name	Mapping Guidance
80689-3	HIV 1 RNA reverse transcriptase and protease and integrase gene mutations detected [Identifier] in Plasma by Sequencing	HIV 1 RNA reverse transcriptase and protease and integrase gene mutations detected [Identifier] in Plasma by Sequencing

Term Description

HIV-1 genotyping resistance assay starts with the isolation of HIV-1 RNA from blood plasma, followed by amplification of the protease (PR), reverse transcriptase (RT) and integrase (IT) coding regions using sequencing methods to determine drug susceptibility. This code is based on, but not limited in use to, the submitter's test kit (GenoSure PRIme),a DNA sequence assay that detects mutations within the protease (amino acids 1-99), reverse transciptase (amino acids 1-400), and integrase (amino acids 1-288) coding regions of HIV-1. Assessment of drug susceptibility is based on the interpretation of mutations identified. It is performed to assess treatment failure, assist in choosing alternate regimens, and to assist in choosing a regimen that will reduce vertical transmission in pregnant HIV infected women.

The answer list provided with this code represents example mutations that may be identified and is not a complete list.
Source: Regenstrief LOINC

Fully-Specified Name

Component: HIV reverse transcriptase+protease+integrase gene mutations detected
Property: Prid
Time: Pt
System: Isolate
Scale: Nom
Method

Additional Names

Short Name: Deprecated HIV RT+PR+IN Mut Det Islt
Display Name: HIV reverse transcriptase+protease+integrase gene mutations detected Nom (Isol)
Consumer Name Alpha Get Info: HIV reverse transcriptase+Protease+Integrase gene variant analysis

Example Answer List: LL2436-5

Source: Laboratory Corporation of America

Answer	Code	Score	Answer ID
V234L HIV mutation in the integrase (IN) coding region			LA24453-5
K13K/E HIV mutation in the reverse transcriptase (RT) coding region			LA19752-7
K20R HIV mutation in the reverse transcriptase (RT) coding region			LA19753-5
E28D HIV mutation in the reverse transcriptase (RT) coding region			LA19754-3
M41M/L HIV mutation in the reverse transcriptase (RT) coding region			LA19755-0
G359S HIV mutation in the reverse transcriptase (RT) coding region			LA25848-5
V35I HIV mutation in the reverse transcriptase (RT) coding region			LA25847-7
K14R HIV mutation in the integrase (IN) coding region			LA19756-8
V31I HIV mutation in the integrase (IN) coding region			LA19757-6
G193E HIV mutation in the integrase (IN) coding region			LA24451-9
D288N HIV mutation in the integrase (IN) coding region			LA24454-3
I62V HIV mutation in the protease (PR) coding region			LA19758-4
Q18K HIV mutation in the protease (PR) coding region			LA25851-9
E35D HIV mutation in the protease (PR) coding region			LA25852-7

Basic Attributes

Class: ABXBACT
Type: Laboratory
First Released: Version 2.44
Last Updated: Version 2.56
Change Reason: This code was deprecated because the Component and System were both incorrect. The mutations are reported separately so the "+" should be an "&", and the System is Plasma, not Isolate.
Order vs. Observation: Both

Language Variants Get Info

Tag	Language	Translation
es-ES	Spanish (Spain)	gen transcriptasa reversa VIH+poteasa+integrasa Detección de mutaciones:Presencia o identidad:Punto temporal:Aislado:Nom:
es-MX	Spanish (Mexico)	Se detectaron mutaciones en el gen de la transcriptasa inversa + proteasa + integrasa del VIH:Presencia o identidad:Punto temporal:Aislado:Nominal:
it-IT	Italian (Italy)	HIV, Trascrittasi Inversa+Geni Proteasi+Integrasi, mutazioni identificate:Prid:Pt:Isolato:Nom: Synonyms: Presenza o Identità Punto nel tempo (episodio) Suscettibilità agli antibiotici
nl-NL	Dutch (Netherlands)	HIV reverse transcriptase + protease + integrase gen gedetecteerde mutaties:identificator:moment:isolaat:nominaal:
pt-BR	Portuguese (Brazil)	HIV reverse transcriptase+protease+integrase gene detecção de mutação:Ident:Pt:Isolado:Nom:
ru-RU	Russian (Russian Federation)	HIV обратная транскриптаза+протеаза+интеграза ген мутации выявлены:ПрИд:ТчкВрм:Изолят:Ном: Synonyms: ВИЧ ВИЧ обратная транскриптаза+протеаза+интеграза ген Номинальный;Именной Присутствие или Идентификация Точка во времени;Момент
tr-TR	Turkish (Turkey)	HIV ters transkriptaz+proteaz+integraz geni mutasyonlar, saptanmış:MevcKimlik:Zmlı:İzolat:Snf:
zh-CN	Chinese (China)	HIV 逆转录酶+蛋白酶+整合酶基因已检出的突变:存在与否或特征标识:时间点:分离株:名义型: Synonyms: AIDS;AIDS 病毒;人类免疫缺陷病毒;人类免疫缺陷病毒（Human immunodeficiency virus，HIV）;爱滋病;艾滋病;艾滋病病毒;获得性免疫缺陷综合征;获得性免疫缺陷综合征（Acquired Immure Deficiency Syndrome，AIDS，艾滋病） HIV（人类免疫缺陷病毒、人免疫缺陷病毒、艾滋病病毒、AIDS 病毒）逆转录酶（反转录酶、逆录酶、RT）与蛋白酶（Prot）与整合酶（IN）基因 RT RTase 倒倒的倒转倒转的分离物;分离菌;分离菌株;隔离种群分类型应答;分类型结果;名义性;名称型;名词型;名词性;标称性;没有自然次序的名义型或分类型应答反向反向的反常反常的反的反相反相的反转录酶存在;存在与否;特征标识;身份;身份标识已发现的突变抗生素敏感性试验;药敏;药敏类;药敏试验;药敏试验类时刻;随机;随意;瞬间朊酶相反相反的突变突变类;基因突变蛋白质酵素逆逆的逆转录酶（Reverse transcriptase，RT）遗传基因;遗传因子;吉恩;生物基因颠倒颠倒的

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