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Status Information

Status
DEPRECATED
Reason
Erroneous
Comment
Both the Component and the System are incorrect. Because the mutations are reported independently for each gene, the "+" in the Component should have been "&", and the System is Plasma, not Isolate.
Map-ToLong Common NameMapping Guidance
80689-3HIV 1 RNA reverse transcriptase and protease and integrase gene mutations detected [Identifier] in Plasma by SequencingHIV 1 RNA reverse transcriptase and protease and integrase gene mutations detected [Identifier] in Plasma by Sequencing

Term Description

HIV-1 genotyping resistance assay starts with the isolation of HIV-1 RNA from blood plasma, followed by amplification of the protease (PR), reverse transcriptase (RT) and integrase (IT) coding regions using sequencing methods to determine drug susceptibility. This code is based on, but not limited in use to, the submitter's test kit (GenoSure PRIme),a DNA sequence assay that detects mutations within the protease (amino acids 1-99), reverse transciptase (amino acids 1-400), and integrase (amino acids 1-288) coding regions of HIV-1. Assessment of drug susceptibility is based on the interpretation of mutations identified. It is performed to assess treatment failure, assist in choosing alternate regimens, and to assist in choosing a regimen that will reduce vertical transmission in pregnant HIV infected women.

The answer list provided with this code represents example mutations that may be identified and is not a complete list.

LOINC Names Get Info

Fully-Specified Name
HIV reverse transcriptase+protease+integrase gene mutations detected:Prid:Pt:Isolate:Nom:
Long Common Name
Deprecated HIV reverse transcriptase+protease+integrase gene mutations detected [Identifier]
Short Name
Deprecated HIV RT+PR+IN Mut Det Islt
Display Name
HIV reverse transcriptase+protease+integrase gene mutations detected Nom (Isol)
Consumer Name Alpha Get Info
HIV reverse transcriptase+Protease+Integrase gene variant analysis

Part Model Get Info

  • Component
    HIV reverse transcriptase+protease+integrase gene mutations detected
    LP286220-1
    • Analyte
      HIV reverse transcriptase+protease+integrase gene mutations detected
      LP286220-1
      • Component Numerator
        HIV reverse transcriptase+protease+integrase gene mutations detected
        LP286220-1
        • Component Numerator Core
          HIV reverse transcriptase+protease+integrase gene
          LP171652-3
        • Component Numerator Core Suffix
          mutations detected
          LP32420-9
      • Component Denominator
        NULL
         
        • Component Denominator Core
          NULL
           
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    Prid
    LP6850-4
  • Time
    Pt
    LP6960-1
  • System
    Isolate
    LP7370-2
    • System Core
      Isolate
      LP7370-2
    • Super System
      NULL
       
  • Scale
    Nom
    LP7750-5
  • Method
    NULL
     

Example Answer List: LL2436-5

Source: Laboratory Corporation of America
AnswerCodeScoreAnswer ID
V234L

HIV mutation in the integrase (IN) coding region

LA24453-5
K13K/E

HIV mutation in the reverse transcriptase (RT) coding region

LA19752-7
K20R

HIV mutation in the reverse transcriptase (RT) coding region

LA19753-5
E28D

HIV mutation in the reverse transcriptase (RT) coding region

LA19754-3
M41M/L

HIV mutation in the reverse transcriptase (RT) coding region

LA19755-0
G359S

HIV mutation in the reverse transcriptase (RT) coding region

LA25848-5
V35I

HIV mutation in the reverse transcriptase (RT) coding region

LA25847-7
K14R

HIV mutation in the integrase (IN) coding region

LA19756-8
V31I

HIV mutation in the integrase (IN) coding region

LA19757-6
G193E

HIV mutation in the integrase (IN) coding region

LA24451-9
D288N

HIV mutation in the integrase (IN) coding region

LA24454-3
I62V

HIV mutation in the protease (PR) coding region

LA19758-4
Q18K

HIV mutation in the protease (PR) coding region

LA25851-9
E35D

HIV mutation in the protease (PR) coding region

LA25852-7

Basic Attributes

Class
ABXBACT
Type
Laboratory
First Released
Version 2.44
Last Updated
Version 2.56 (DEL)
Change Reason
This code was deprecated because the Component and System were both incorrect. The mutations are reported separately so the "+" should be an "&", and the System is Plasma, not Isolate.
Order vs. Observation
Both

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)HIV reverzní transkriptáza+proteáza+integráza genové mutace detekované:Přítomnost nebo identita:Časový bod:Izolát:Nominální:
el-GRGreek (Greece)Γονίδιο αντίστροφης μεταγραφάσης του ιού της ανθρώπινης ανοσοανεπάρκειας+πρωτεάσης+ιντεγκράσης ανιχνευθείσες μεταλλάξεις:Prid:Pt:Απομονωμένο στέλεχος:Nom:
Synonyms: ABXBACT Nom Prid Pt ανιχνευθείσες μεταλλάξεις Απομονωμένο στέλεχος Γονίδιο Γονίδιο αντίστροφης μεταγραφάσης του ιού της ανθρώπινης ανοσοανεπάρκειας+πρωτεάσης+ιντεγκράσης Ιός ανθρώπινης ανοσοανεπάρκειας Μεταλλάξεις
es-ESSpanish (Spain)gen transcriptasa reversa VIH+poteasa+integrasa Detección de mutaciones:Presencia o identidad:Punto temporal:Aislado:Nom:
es-MXSpanish (Mexico)Se detectaron mutaciones en el gen de la transcriptasa inversa + proteasa + integrasa del VIH:Presencia o identidad:Punto temporal:Aislado:Nominal:
it-ITItalian (Italy)HIV, Trascrittasi Inversa+Geni Proteasi+Integrasi, mutazioni identificate:Prid:Pt:Isolato:Nom:
Synonyms: Presenza o Identità Punto nel tempo (episodio) Suscettibilità agli antibiotici
nl-NLDutch (Netherlands)HIV reverse transcriptase + protease + integrase gen gedetecteerde mutaties:identificator:moment:isolaat:nominaal:
pl-PLPolish (Poland)HIV Odwrotna transkryptaza+proteaza+integraza gen wykryte mutacje:obecność lub identyfikacja:punkt w czasie:izolat:skala nominalna:
Synonyms: Geny odwrotnej transkryptazy, proteazy i integrazy HIV;Geny odwrotnej transkryptazy, proteazy i integrazy ludzkiego wirusa niedoboru odporności Ludzki wirus niedoboru odporności wynik kategorialny
pt-BRPortuguese (Brazil)HIV reverse transcriptase+protease+integrase gene detecção de mutação:Ident:Pt:Isolado:Nom:
ru-RURussian (Russian Federation)HIV обратная транскриптаза+протеаза+интеграза ген мутации выявлены:ПрИд:ТчкВрм:Изолят:Ном:
Synonyms: ВИЧ ВИЧ обратная транскриптаза+протеаза+интеграза ген Номинальный;Именной Присутствие или Идентификация Точка во времени;Момент
tr-TRTurkish (Turkey)HIV ters transkriptaz+proteaz+integraz geni mutasyonlar, saptanmış:MevcKimlik:Zmlı:İzolat:Snf:
zh-CNChinese (China)HIV 逆转录酶+蛋白酶+整合酶基因 已检出的突变:存在与否或特征标识:时间点:分离株:名义型:
Synonyms: AIDS;AIDS 病毒;人类免疫缺陷病毒;人类免疫缺陷病毒（Human immunodeficiency virus，HIV）;爱滋病;艾滋病;艾滋病病毒;获得性免疫缺陷综合征;获得性免疫缺陷综合征（Acquired Immure Deficiency Syndrome，AIDS，艾滋病） HIV（人类免疫缺陷病毒、人免疫缺陷病毒、艾滋病病毒、AIDS 病毒）逆转录酶（反转录酶、逆录酶、RT）与蛋白酶（Prot）与整合酶（IN）基因 RT RTase 倒 倒的 倒转 倒转的 分离物;分离菌;分离菌株;隔离种群 分类型应答;分类型结果;名义性;名称型;名词型;名词性;标称性;没有自然次序的名义型或分类型应答 反向 反向的 反常 反常的 反的 反相 反相的 反转录酶 存在;存在与否;特征标识;身份;身份标识 已发现的突变 抗生素敏感性试验;药敏;药敏类;药敏试验;药敏试验类 时刻;随机;随意;瞬间 朊酶 相反 相反的 突变 突变类;基因突变 蛋白质酵素 逆 逆的 逆转录酶（Reverse transcriptase，RT） 遗传基因;遗传因子;吉恩;生物基因 颠倒 颠倒的

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