Version 2.77

Term Description

Immunohistochemistry is performed on tissues positive for prion protein to identify the type of TSE (e.g. BSE type-C, atypical BSE H or L types, scrapie, Nor98, etc.).
Source: Regenstrief LOINC

Part Description

LP35078-2   Prion protein.abnormal
Transmissible spongiform encephalopathies (TSEs), also known as prion diseases, are a group of progressive conditions (encephalopathies) that affect the brain and nervous system of many animals, including humans. According to the most widespread hypothesis they are transmitted by abnormal prions, though some other data suggest an involvement of a Spiroplasma infection. Mental and physical abilities deteriorate and a myriad of tiny holes appear in the cortex causing it to appear like a sponge (hence spongiform) when brain tissue obtained at autopsy is examined under a microscope. The disorders cause impairment of brain function, including memory changes, personality changes and problems with movement that worsen over time. Most TSEs are sporadic and occur in animals. Prion diseases of animals in include classical bovine spongiform encephalopathy (BSE) (C-type), atypical (H or L-type) BSE, Scrapie, atypical scrapie, Nor98, and chronic wasting disease (CWE). H-type and L-type BSE were named based on abnormal prion bands migrating to a higher (H) or lower (L) position on western blot analysis compared to the classical BSE (C-type) prion protein. Prion diseases of humans include classic Creutzfeldt-Jakob disease, new variant Creutzfeldt-Jakob disease (nvCJD, a human disorder related to Bovine spongiform encephalopathy), Gerstmann-Sträussler-Scheinker syndrome, fatal familial insomnia and kuru. These conditions form a spectrum of diseases with overlapping signs and symptoms. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See for details. Source: Wikipedia, Transmissible spongiform encephalopathy

Fully-Specified Name

Prion protein.abnormal
Immune stain

Additional Names

Short Name
Abn Prion Prot Tiss ImStn
Display Name
Abnormal Prion Protein Immune stain Nom (Tiss)
Consumer Name Alpha Get Info
Abnormal prion protein, Tissue

Example Answer List: LL2536-2

Source: American Association of Veterinary Laboratory Diagnosticians
Answer Code Score Answer ID
Bovine spongiform encephalopathy (BSE) - C type

Classical BSE (C type)

Atypical Bovine spongiform encephalopathy (BSE) - H type

H type BSE are named by the band migration on western blot - higher position that Classical (C-type) BSE.

Atypical Bovine spongiform encephalopathy (BSE) - L type

L type BSE are named by the band migration on western blot - lower position that Classical (C-type) BSE.

Scrapie LA20108-9
Atypical scrapie LA20109-7
Nor98 LA20111-3
Chronic wasting disease (CWD) LA20110-5
NegativeCopyright ID:260385009 Negative (qualifier value) LA6577-6

Basic Attributes

First Released
Version 2.46
Last Updated
Version 2.46
Order vs. Observation

Language Variants Get Info

Tag Language Translation
de-DE German (Germany) Prionenprotein.abnorm:Nachweis oder Identität:Zeitpunkt:Gewebe:Nominal:Immunfärbung
es-ES Spanish (Spain) Proteína priónica anormal:Presencia o identidad:Punto temporal:Tejido:Nom:Tinción de inmunohistoquímica
es-MX Spanish (Mexico) Proteína priónica anormal:Presencia o identidad:Punto temporal:Tejido y frotis:Nominal:Mancha inmune
fr-CA French (Canada) Protéines prion.anormales:Présence ou identité:Temps ponctuel:Tissu:Nominal:Coloration immunologique
fr-FR French (France) Protéine prion anormale:Identification:Ponctuel:Tissu:Résultat nominal:Coloration immune
fr-BE French (Belgium) Protéines prion.anormales:Présence ou identité:Temps ponctuel:Tissu:Nominal:Coloration immunologique
Synonyms: Coloration. Méthode mmunologique
it-IT Italian (Italy) Proteina prionica.anormale:Prid:Pt:Tessuto:Nom:Colorazione immunologica
Synonyms: Microbiologia Presenza o Identità Proteina Prionica Anormale Punto nel tempo (episodio) Tessuto & Strisci
nl-NL Dutch (Netherlands) prioneiwit.abnormaal:identificator:moment:weefsel en uitstrijkjes:nominaal:immunokleuring
pt-BR Portuguese (Brazil) Proteína prion.anormal:Ident:Pt:Tecido:Nom:Imunocoloração
ru-RU Russian (Russian Federation) Прионный протеин.аномальный:ПрИд:ТчкВрм:Тк:Ном:Иммуногистохимическая окраска
Synonyms: Белок Номинальный;Именной Прионный белок.аномальный Присутствие или Идентификация Ткань и мазки Точка во времени;Момент
tr-TR Turkish (Turkey) Prion protein.anormal:MevcKimlik:Zmlı:Doku:Snf:İmmün boyama
zh-CN Chinese (China) 朊病毒蛋白.异常:存在与否或特征标识:时间点:组织与涂片:名义型:免疫染色法
Synonyms: BSE;Scrapie;亲染子蛋白.异常;异常亲染子蛋白;异常感染性蛋白质;异常朊病毒蛋白;异常蛋白感染素;感染性蛋白质.异常;牛海绵状脑病;牛海绵状脑病(Bovine spongiform encephalopathy,BSE);疯牛病;羊痒病;羊瘙痒病;羊瘙痒病(Scrapie);蛋白感染素.异常 PR;Prot;成分 - 化学 - 蛋白质类;蛋白;朊;蛋白质类;蛋白质类物质 不平常的 不正常的 亲染子蛋白 免疫染色;免疫组化;免疫组化染色;免疫组化染色法;免疫组化法;免疫组织化学染色;免疫组织化学染色法;细胞免疫染色;细胞免疫染色法 分类型应答;分类型结果;名义性;名称型;名词型;名词性;标称性;没有自然次序的名义型或分类型应答 反常的 存在;存在与否;特征标识;身份;身份标识 异常的 微生物学;微生物学试验;微生物学试验(培养、DNA、抗原及抗体) 感染性蛋白质 时刻;随机;随意;瞬间 未作说明的组织;组织;组织 & 涂片 染法 染色方法 染色法 着色 着色方法 着色法 蛋白感染素 非一般的 非惯例的

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