74036-5

Abnormal Prion Protein [Identifier] in Tissue by Immunoblot

Active

Term Description

Western blot analysis is performed on tissues positive for prion protein to identify the type of TSE (e.g. BSE, atypical BSE, scrapie, Nor98, etc.).

Part Description

LP35078-2   Prion protein.abnormal
Transmissible spongiform encephalopathies (TSEs), also known as prion diseases, are a group of progressive conditions (encephalopathies) that affect the brain and nervous system of many animals, including humans. According to the most widespread hypothesis they are transmitted by abnormal prions, though some other data suggest an involvement of a Spiroplasma infection. Mental and physical abilities deteriorate and a myriad of tiny holes appear in the cortex causing it to appear like a sponge (hence spongiform) when brain tissue obtained at autopsy is examined under a microscope. The disorders cause impairment of brain function, including memory changes, personality changes and problems with movement that worsen over time. Most TSEs are sporadic and occur in animals. Prion diseases of animals in include classical bovine spongiform encephalopathy (BSE) (C-type), atypical (H or L-type) BSE, Scrapie, atypical scrapie, Nor98, and chronic wasting disease (CWE). H-type and L-type BSE were named based on abnormal prion bands migrating to a higher (H) or lower (L) position on western blot analysis compared to the classical BSE (C-type) prion protein. Prion diseases of humans include classic Creutzfeldt-Jakob disease, new variant Creutzfeldt-Jakob disease (nvCJD, a human disorder related to Bovine spongiform encephalopathy), Gerstmann-Sträussler-Scheinker syndrome, fatal familial insomnia and kuru. These conditions form a spectrum of diseases with overlapping signs and symptoms. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Transmissible spongiform encephalopathy

LOINC Names Get Info

Fully-Specified Name

Prion protein.abnormal:Prid:Pt:Tiss:Nom:IB

Long Common Name

Abnormal Prion Protein [Identifier] in Tissue by Immunoblot

Short Name

Abn Prion Prot Tiss IB

Display Name

Abnormal Prion Protein IB Nom (Tiss)

Consumer Name Alpha Get Info

Abnormal prion protein, Tissue

Part Model Get Info

• Component

  Prion protein.abnormal
  LP35078-2

  • Analyte

    Prion protein.abnormal
    LP35078-2

    • Component Numerator

      Prion protein.abnormal
      LP35078-2

      • Component Numerator Core

        Prion protein.abnormal
        LP35078-2

      • Component Numerator Core Suffix

        NULL
         

    • Component Denominator

      NULL
       

      • Component Denominator Core

        NULL
         

      • Component Denominator Core Suffix

        NULL
         

  • Challenge

    NULL
     

  • Adjustment

    NULL
     

  • Count

    NULL
     

• Property

  Prid
  LP6850-4

• Time

  Pt
  LP6960-1

  • Time Core

    Pt
    LP6960-1

  • Time Modifier

    NULL
     

• System

  Tiss
  LP7641-6

  • System Core

    Tiss
    LP7641-6

  • Super System

    NULL
     

• Scale

  Nom
  LP7750-5

• Method

  IB
  LP6320-8

Example Answer List: LL2536-2

Basic Attributes

Class

MICRO

Type

Laboratory

First Released

Version 2.46

Last Updated

Version 2.58 (MIN)

Order vs. Observation

Both

Language Variants Get Info

Related Names

• abn
• Abn Prion Prot
• abnorm
• Blt
• Bovine spongiform encephalopathy
• BSE
• Identity or presence
• Immune blot
• Immunobl
• Immunoblot
• Microbiology
• Neuro
• Neurology
• Nominal
• Point in time
• PR
• Prot
• PrP
• Random
• RIBA
• Scrapie
• Tissue
• Tissue, unspecified
• WB
• WBLOT
• West blot
• West blt
• Western blot

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CodeSystem lookup

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Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.