74036-5
Abnormal Prion Protein [Identifier] in Tissue by Immunoblot
Active
Term Description
Western blot analysis is performed on tissues positive for prion protein to identify the type of TSE (e.g. BSE, atypical BSE, scrapie, Nor98, etc.).
Source: Regenstrief LOINC
Part Description
LP35078-2 Prion protein.abnormal
Transmissible spongiform encephalopathies (TSEs), also known as prion diseases, are a group of progressive conditions (encephalopathies) that affect the brain and nervous system of many animals, including humans. According to the most widespread hypothesis they are transmitted by abnormal prions, though some other data suggest an involvement of a Spiroplasma infection. Mental and physical abilities deteriorate and a myriad of tiny holes appear in the cortex causing it to appear like a sponge (hence spongiform) when brain tissue obtained at autopsy is examined under a microscope. The disorders cause impairment of brain function, including memory changes, personality changes and problems with movement that worsen over time. Most TSEs are sporadic and occur in animals. Prion diseases of animals in include classical bovine spongiform encephalopathy (BSE) (C-type), atypical (H or L-type) BSE, Scrapie, atypical scrapie, Nor98, and chronic wasting disease (CWE). H-type and L-type BSE were named based on abnormal prion bands migrating to a higher (H) or lower (L) position on western blot analysis compared to the classical BSE (C-type) prion protein. Prion diseases of humans include classic Creutzfeldt-Jakob disease, new variant Creutzfeldt-Jakob disease (nvCJD, a human disorder related to Bovine spongiform encephalopathy), Gerstmann-Sträussler-Scheinker syndrome, fatal familial insomnia and kuru. These conditions form a spectrum of diseases with overlapping signs and symptoms.
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Source: Wikipedia, Transmissible spongiform encephalopathy
Fully-Specified Name
- Component
- Prion protein.abnormal
- Property
- Prid
- Time
- Pt
- System
- Tiss
- Scale
- Nom
- Method
- IB
Additional Names
- Short Name
- Abn Prion Prot Tiss IB
- Display Name
- Abnormal Prion Protein IB Nom (Tiss)
- Consumer Name Alpha Get Info
- Abnormal prion protein, Tissue
Example Answer List: LL2536-2
Source: American Association of Veterinary Laboratory Diagnosticians| Answer | Code | Score | Answer ID |
|---|---|---|---|
| Bovine spongiform encephalopathy (BSE) - C type Classical BSE (C type) |
LA20104-8 | ||
| Atypical Bovine spongiform encephalopathy (BSE) - H type H type BSE are named by the band migration on western blot - higher position that Classical (C-type) BSE. |
LA20106-3 | ||
| Atypical Bovine spongiform encephalopathy (BSE) - L type L type BSE are named by the band migration on western blot - lower position that Classical (C-type) BSE. |
LA20107-1 | ||
| Scrapie | LA20108-9 | ||
| Atypical scrapie | LA20109-7 | ||
| Nor98 | LA20111-3 | ||
| Chronic wasting disease (CWD) | LA20110-5 | ||
| NegativeCopyright http://snomed.info/sct ID:260385009 Negative (qualifier value) | LA6577-6 |
Basic Attributes
- Class
- MICRO
- Type
- Laboratory
- First Released
- Version 2.46
- Last Updated
- Version 2.58
- Order vs. Observation
- Both
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| de-DE | German (Germany) | Prionenprotein.abnorm: |
| es-ES | Spanish (Spain) | Proteína priónica anormal: |
| es-MX | Spanish (Mexico) | Proteína priónica anormal: |
| fr-CA | French (Canada) | Protéines prion.anormales: |
| fr-FR | French (France) | Protéine prion anormale: |
| fr-BE | French (Belgium) | Protéines prion.anormales: |
| it-IT | Italian (Italy) | Proteina prionica.anormale: Synonyms: Immunoblot (IB) Microbiologia Presenza o Identità Proteina Prionica Anormale Punto nel tempo (episodio) Tessuto & |
| nl-NL | Dutch (Netherlands) | prioneiwit.abnormaal: Synonyms: IB |
| pt-BR | Portuguese (Brazil) | Proteína prion.anormal: |
| ru-RU | Russian (Russian Federation) | Прионный протеин.аномальный: Synonyms: Белок Иммуноблот (ИБ) Номинальный; |
| tr-TR | Turkish (Turkey) | Prion protein.anormal: |
| zh-CN | Chinese (China) | 朊病毒蛋白.异常: Synonyms: BSE; |
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