74109-0
4-hydroxycoumarins [Presence] in Specimen by Screen method
Active
Term Description
Screening for 4-hydroxycoumarins, such as warfarin, difenacoum, bromadiolone, and coumatetralyl, is performed to detect intentional or accidental poisoning from rodenticides. The overall screen result may be reported as "positive" or "negative" based on individual results for 4-hydroxycoumarins (rodenticides) tested.
Source: Regenstrief LOINC
Part Description
LP173607-5 4-hydroxycoumarins
4-Hydroxycoumarins are a class of vitamin K antagonist (VKA) anticoagulant drug molecules derived from coumarin (chromen-2-one). The primary mechanism of the 4-hydroxycoumarin drugs is the inhibition of vitamin K epoxide reductase. The synthetic drugs in the 4-hydroxycoumarin class are all noted primarily for their use as anticoagulants, though they can have several additional effects. The simplest synthetic molecule in the 4-hydroxycoumarin class is warfarin, in which the aromatic 3-position substituent is a simple phenyl group. So called "super-warfarins" or second-generation anticoagulants in this class, were developed as rodenticides for rodents that have developed warfarin resistance. The second generation agents have even larger lipid-soluble substituents at the 3-position (e.g. brodifacoum), a chemical change that causes their half life in the body to be greatly increased (sometimes to months). The antirodenticide chemicals are sometimes incorrectly referred to as "coumadins" rather than 4-hydroxycoumarins (Coumadin is a brandname for warfarin).
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Source: Wikipedia, 4-hydroxycoumarins
Fully-Specified Name
- Component
- 4-hydroxycoumarins
- Property
- PrThr
- Time
- Pt
- System
- XXX
- Scale
- Ord
- Method
- Screen
Additional Names
- Short Name
- 4OH-coumarins Spec Ql Scn
- Display Name
- 4-hydroxycoumarins Screen Ql (Specimen)
- Consumer Name Alpha Get Info
- 4-hydroxycoumarins, Specimen
Example Answer List: LL360-9
Source: Regenstrief InstituteAnswer | Code | Score | Answer ID |
---|---|---|---|
PositiveCopyright http://snomed.info/sct ID:10828004 Positive (qualifier value) | LA6576-8 | ||
NegativeCopyright http://snomed.info/sct ID:260385009 Negative (qualifier value) | LA6577-6 |
Basic Attributes
- Class
- DRUG/TOX
- Type
- Laboratory
- First Released
- Version 2.46
- Last Updated
- Version 2.73
- Change Reason
- The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
- Order vs. Observation
- Both
- Common Test Rank Get Info
- 16879
Language Variants Get Info
Tag | Language | Translation |
---|---|---|
es-ES | Spanish (Spain) | 4-hidroxicumarina: |
es-MX | Spanish (Mexico) | 4-hidroxicumarinas: |
fr-FR | French (France) | 4-hydroxycoumarines: |
it-IT | Italian (Italy) | 4-idrossicumarina: Synonyms: Livelli farmacologici e tossicologia Presenza o Soglia Punto nel tempo (episodio) Screening tossicologico |
nl-NL | Dutch (Netherlands) | 4-hydroxycoumarinen: |
pt-BR | Portuguese (Brazil) | 4-hidroxicoumarinas: |
ru-RU | Russian (Russian Federation) | 4-гидроксикумарины: Synonyms: Порядковый Токсикологический скрининг Точка во времени; |
tr-TR | Turkish (Turkey) | 4-Hidroksikumarinler: Synonyms: Mevcut |
zh-CN | Chinese (China) | 4-羟基香豆素类: Synonyms: 4-羟基香豆素; |
LOINC Terminology Service (API) using HL7® FHIR® Get Info
Requests to this service require a free LOINC username and password. Below is a sample of the possible capabilities. See the LOINC Terminology Service documentation for more information.
- CodeSystem lookup
- https:
//fhir.loinc.org/CodeSystem/$lookup?system=http: //loinc.org&code=74109-0
Third Party Copyright
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LOINC Copyright
Copyright © 2024 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright