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Term Description

Screening for 4-hydroxycoumarins, such as warfarin, difenacoum, bromadiolone, and coumatetralyl, is performed to detect intentional or accidental poisoning from rodenticides. The overall screen result may be reported as "positive" or "negative" based on individual results for 4-hydroxycoumarins (rodenticides) tested.

Part Description

LP173607-5   4-hydroxycoumarins
4-Hydroxycoumarins are a class of vitamin K antagonist (VKA) anticoagulant drug molecules derived from coumarin (chromen-2-one). The primary mechanism of the 4-hydroxycoumarin drugs is the inhibition of vitamin K epoxide reductase. The synthetic drugs in the 4-hydroxycoumarin class are all noted primarily for their use as anticoagulants, though they can have several additional effects. The simplest synthetic molecule in the 4-hydroxycoumarin class is warfarin, in which the aromatic 3-position substituent is a simple phenyl group. So called "super-warfarins" or second-generation anticoagulants in this class, were developed as rodenticides for rodents that have developed warfarin resistance. The second generation agents have even larger lipid-soluble substituents at the 3-position (e.g. brodifacoum), a chemical change that causes their half life in the body to be greatly increased (sometimes to months). The antirodenticide chemicals are sometimes incorrectly referred to as "coumadins" rather than 4-hydroxycoumarins (Coumadin is a brandname for warfarin). Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, 4-hydroxycoumarins

LOINC Names Get Info

Fully-Specified Name
4-hydroxycoumarins:PrThr:Pt:XXX:Ord:Screen
Long Common Name
4-hydroxycoumarins [Presence] in Specimen by Screen method
Short Name
4OH-coumarins Spec Ql Scn
Display Name
4-hydroxycoumarins Screen Ql (Specimen)
Consumer Name Alpha Get Info
4-hydroxycoumarins, Specimen

Part Model Get Info

  • Component
    4-hydroxycoumarins
    LP173607-5
    • Analyte
      4-hydroxycoumarins
      LP173607-5
      • Component Numerator
        4-hydroxycoumarins
        LP173607-5
        • Component Numerator Core
          4-hydroxycoumarins
          LP173607-5
        • Component Numerator Core Suffix
          NULL
           
      • Component Denominator
        NULL
         
        • Component Denominator Core
          NULL
           
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    PrThr
    LP217195-9
  • Time
    Pt
    LP6960-1
  • System
    XXX
    LP7735-6
    • System Core
      XXX
      LP7735-6
    • Super System
      NULL
       
  • Scale
    Ord
    LP7751-3
  • Method
    Screen
    LP6503-9

Example Answer List: LL360-9

Source: Regenstrief Institute
AnswerCodeScoreAnswer ID
PositiveCopyright http://snomed.info/sct ID:10828004 Positive (qualifier value)LA6576-8
NegativeCopyright http://snomed.info/sct ID:260385009 Negative (qualifier value)LA6577-6

Basic Attributes

Class
DRUG/TOX
Type
Laboratory
First Released
Version 2.46
Last Updated
Version 2.73 (MIN)
Change Reason
The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation
Both
Common Test Rank Get Info
16879

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)4-hydroxykumariny:Přítomnost nebo práh:Časový bod:XXX:Ordinální:Screening toxikologický
el-GRGreek (Greece)4-υδροξυκουμαρίνες:PrThr:Pt:XXX:Ord:Έλεγχος
Synonyms: 4-υδροξυκουμαρίνες DRUG/TOX Ord PrThr Pt XXX Έλεγχος
es-ESSpanish (Spain)4-hidroxicumarina:PrThr:Punto temporal:XXX:Ord:Cribado toxicológico
es-MXSpanish (Mexico)4-hidroxicumarinas:Presencia o umbral:Punto temporal:XXX:Ordinal:Pantalla de toxicología
fr-FRFrench (France)4-hydroxycoumarines:Présence/Seuil:Ponctuel:Milieux divers:Qualitatif:Dépistage
it-ITItalian (Italy)4-idrossicumarina:PrThr:Pt:XXX:Ord:Screening
Synonyms: Livelli farmacologici e tossicologia Presenza o Soglia Punto nel tempo (episodio) Screening tossicologico
nl-NLDutch (Netherlands)4-hydroxycoumarinen:aanwezigheid:moment:XXX:ordinaal:screening
pl-PLPolish (Poland)4-Hydroksykumaryny:granica wykrywalności:punkt w czasie:XXX:uporządkowany:metoda przesiewowa
ru-RURussian (Russian Federation)4-гидроксикумарины:PrThr:ТчкВрм:XXX:Пор:Скрининг
Synonyms: Порядковый Токсикологический скрининг Точка во времени;Момент
tr-TRTurkish (Turkey)4-Hidroksikumarinler:MevcEşik:Zmlı:XXX:Srl:Tarama
Synonyms: Mevcut
zh-CNChinese (China)4-羟基香豆素类:存在情况或阈值:时间点:XXX:序数型:毒理学筛查试验
Synonyms: 4-羟基香豆素;4-羟基香豆精类;4-羟基香豆精;4-羟香豆素类 不明的;其他;将在相应消息内其他部分之中加以详细说明;未作详细说明的;未作说明的;未做说明的标本;未加规定的;未加说明的标本;杂项 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值） 时刻;随机;随意;瞬间 毒品 毒品类 筛查 筛查方法;筛查法;筛查试验 筛查试验 筛选试验 药品类 药物 药物/毒理学;药物/毒理学试验;药物毒理学试验;药物毒理学试验类 药物类 过筛 过筛试验

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=74109-0