Version 2.80

Term Description

The count of spots (0 to >20) in a patient's T cells that represent IFN-γ released in response to the presence of M. tuberculosis culture filtrate protein 10 (CFP10) antigens. The spot count provides a measurement of the abundance of Mycobacterium tuberculosis sensitive effector T cells in the peripheral blood. This term is based on, but not limited in use to, Oxford Immunotec's T-SPOT.TB assay, used to diagnose M. tuberculosis. T-SPOT.TB assay uses enzyme-linked immunospot (ELISPOT) methodology to enumerate M. tuberculosis-sensitized T cells by capturing interferon-gamma (IFN-y) in the vicinity of T cells in the patient's whole blood. In the T-SPOT.TB assay, the test result is positive if [ESAT-6 (Panel A) - negative control spots] and/or [CFP10 (Panel B) - negative control spots] is greater than or equal to 8 spots. The test result is negative if both [Panel A - negative control] and/or [Panel B - negative control] is less than or equal to 4 spots.

Part Description

LP173644-8   Mycobacterium tuberculosis stimulated gamma interferon.CFP10 Ag spot count
CFP10, also known as ESAT-6-like protein esxB, is a protein that is encoded by the esxB gene. CFP10 is a 10 kDa secreted antigen from Mycobacterium tuberculosis. It forms a 1:1 heterodimeric complex with ESAT-6. Both genes are expressed from the RD1 region of the bacterial genome and play a key role in the virulence of the infection. It is used in tuberculosis diagnosis by whole blood interferon γ tests, e.g. QuantiFERON-TB Gold and T-SPOT.TB, in conjunction with ESAT-6 and TB7.7 (QuantiFERON-TB Gold). Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia , CFP10

Fully-Specified Name

Component
Mycobacterium tuberculosis stimulated gamma interferon.CFP10 Ag spot count
Property
Num
Time
Pt
System
Bld
Scale
Qn
Method

Additional Names

Long Common Name
Mycobacterium tuberculosis stimulated gamma interferon CFP10 Ag spot count [#] in Blood
Short Name
M TB IFN-g.CFP10 Ag Bld
Display Name
M. tuberculosis stim IFN-g CFP10 Ag spot count (Bld) [#]
Consumer Name Alpha Get Info
Mycobacterium tuberculosis stimulated gamma interferon.CFP10 Ag spot count, Blood

Basic Attributes

Class
MICRO
Type
Laboratory
First Released
Version 2.46
Last Updated
Version 2.64 (MIN)
Order vs. Observation
Both

Formula (Readable)

Total Panel B (CFP-10 Ag) spot count = Panel B (CFP-10 Ag) spot count - Negative control spot count

Member of these Panels

LOINC Long Common Name
74281-7 Mycobacterium tuberculosis stimulated gamma interferon and spot count panel - Blood

Language Variants Get Info

Tag Language Translation
el-GR Greek (Greece) Διεγερμένη από Mycobacterium tuberculosis (Μυκοβακτηρίδιο της φυματίωσης) γ-ιντερφερόνη.μέτρηση κηλίδων αντιγόνου CFP10:Αρ.:Pt:Αίμα:Qn:
Synonyms: Mycobacterium tuberculosis (Μυκοβακτηρίδιο της φυματίωσης) Αρ. Διεγερμένη από Mycobacterium tuberculosis (Μυκοβακτηρίδιο της φυματίωσης) γ-ιντερφερόνη Διεγερμένη από Mycobacterium tuberculosis (Μυκοβακτηρίδιο της φυματίωσης) γ-ιντερφερόνη.μέτρηση κηλίδων αντιγόνου CFP10 Ιντερφερόνη
es-ES Spanish (Spain) Mycobacterium tuberculosis estimulado con interferón gamma antígeno CFP10 recuento de manchas:Número (recuento):Punto temporal:Sangre:Qn:
Synonyms: Cuantitativo
es-MX Spanish (Mexico) Interferón gamma estimulado por Mycobacterium tuberculosis.CFP10 Ag spot count:Número (recuento):Punto temporal:Sangre:Cuantitativo:
fr-FR French (France) Interféron gamma stimulé par mycobacterium tuberculosis antigène CFP10 spots comptés:Nombre:Ponctuel:Sang:Numérique:
it-IT Italian (Italy) Interferone gamma stimolato da bacillo di Koch.Antigeni CFP10 numero di spot:Num:Pt:Sangue:Qn:
Synonyms: Gamma interferone stimolato da Mycobacterium tuber Micobatterio della tubercolosi Microbiologia Numero (conta) Punto nel tempo (episodio) Sangue
nl-NL Dutch (Netherlands) Mycobacterium tuberculosis-gestimuleerde gamma-interferon CFP10-Ag spot count:aantal:moment:bloed:kwantitatief:
pl-PL Polish (Poland) Stymulowany przez Mycobacterium tuberculosis interferon gamma.Liczba spotów Ag CFP10:liczba:punkt w czasie:krew:ilościowy:
Synonyms: Stymulowany przez Mycobacterium tuberculosis interferon gamma.Liczba spotów Ag CFP10
pt-BR Portuguese (Brazil) Mycobacterium tuberculosis estimulada gama interferon.CFP10 Ag contagem de ponto::Pt:SgTotal:Qn:
ru-RU Russian (Russian Federation) Mycobacterium tuberculosis стимулированный гамма интерферон.CFP10 Аг пятно количество панель:Кол:ТчкВрм:Кр:Колич:
Synonyms: Количественный Количество Кровь Точка во времени;Момент
tr-TR Turkish (Turkey) Mycobacterium tuberculosis uyarılmış gamma interferon.CFP10 Ag spot sayım:Say:Zmlı:Kan:Kant:
zh-CN Chinese (China) 结核分枝杆菌刺激型 gamma 干扰素.CFP10 抗原斑点计数:数量(计数):时间点:全血:定量型:
Synonyms: AFB IFN 个数;数量;数量或计数（非负整数）;计数 分支杆菌 分支杆菌属 分枝杆菌属 劳瘵 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 微生物学;微生物学试验;微生物学试验（培养、DNA、抗原及抗体） 抗酸 抗酸杆菌 抗酸杆菌（Acid fast bacillus，AFB） 抗酸菌 时刻;随机;随意;瞬间 痨 痨病 结核 结核;肺结核;痨;痨病;TB 结核分支杆菌;结核杆菌;结核菌 结核分枝杆菌刺激型 gamma 干扰素（γ干扰素、IFN-γ） 结核分枝杆菌刺激型 gamma 干扰素（γ干扰素、IFN-γ）.CFP10 抗原斑点（斑、点）计数 结核病 肺结核 血;血液

Example Units

Unit Source
{#} Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=74277-5