74278-3
Mycobacterium tuberculosis stimulated gamma interferon ESAT-6 Ag spot count [#] in Blood
Active
Term Description
The count of spots (0 to >20) in a patient's T cells that represent IFN-γ released in response to the presence of M. tuberculosis early secretory antigenic target-6 (ESAT-6) antigens. The spot count provides a measurement of the abundance of Mycobacterium tuberculosis sensitive effector T cells in the peripheral blood. This term is based on, but not limited in use to, Oxford Immunotec's T-SPOT.TB assay, used to diagnose M. tuberculosis. T-SPOT.TB assay uses enzyme-linked immunospot (ELISPOT) methodology to enumerate M. tuberculosis-sensitized T cells by capturing interferon-gamma (IFN-y) in the vicinity of T cells in the patient's whole blood. In the T-SPOT.TB assay, the test result is positive if [ESAT-6 (Panel A) - negative control spots] and/or [CFP10 (Panel B) - negative control spots] is greater than or equal to 8 spots. The test result is negative if both [Panel A - negative control] and/or [Panel B - negative control] is less than or equal to 4 spots.
Part Description
LP173642-2 Mycobacterium tuberculosis stimulated gamma interferon.ESAT-6 Ag spot count
ESAT-6, the 6 kDa early secretory antigenic target of Mycobacterium tuberculosis, is a secretory protein and potent T cell antigen. It is used in tuberculosis diagnosis by whole blood interferon γ tests, e.g. QuantiFERON-TB Gold and T-SPOT.TB, in conjunction with CFP-10 and TB7.7 (QuantiFERON-TB Gold). ESAT-6 has been shown to directly bind to the TLR2 receptor, inhibiting downstream signal transduction.
Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details.
Source: Wikipedia
, ESAT-6
Fully-Specified Name
- Component
- Mycobacterium tuberculosis stimulated gamma interferon.ESAT-6 Ag spot count
- Property
- Num
- Time
- Pt
- System
- Bld
- Scale
- Qn
- Method
Additional Names
- Long Common Name
- Mycobacterium tuberculosis stimulated gamma interferon ESAT-6 Ag spot count [#] in Blood
- Short Name
- M TB IFN-g.ESAT-6 Ag Bld
- Display Name
- M. tuberculosis stim IFN-g ESAT-6 Ag spot count (Bld) [#]
- Consumer Name Alpha Get Info
- Mycobacterium tuberculosis stimulated gamma interferon.ESAT-6 Ag spot count, Blood
Basic Attributes
- Class
- MICRO
- Type
- Laboratory
- First Released
- Version 2.46
- Last Updated
- Version 2.64 (MIN)
- Order vs. Observation
- Both
Member of these Panels
LOINC | Long Common Name |
---|---|
74281-7 | Mycobacterium tuberculosis stimulated gamma interferon and spot count panel - Blood |
Language Variants Get Info
Tag | Language | Translation |
---|---|---|
el-GR | Greek (Greece) | Διεγερμένη από Mycobacterium tuberculosis (Μυκοβακτηρίδιο της φυματίωσης) γ-ιντερφερόνη.μέτρηση κηλίδων αντιγόνου ESAT-6: Synonyms: Mycobacterium tuberculosis (Μυκοβακτηρίδιο της φυματίωσης) Αρ. Διεγερμένη από Mycobacterium tuberculosis (Μυκοβακτηρίδιο της φυματίωσης) γ-ιντερφερόνη Διεγερμένη από Mycobacterium tuberculosis (Μυκοβακτηρίδιο της φυματίωσης) γ-ιντερφερόνη.μέτρηση κηλίδων αντιγόνου ESAT-6 Ιντερφερόνη |
es-ES | Spanish (Spain) | Mycobacterium tuberculosis estimulado con interferón gamma antígeno ESAT-6 recuento de manchas: Synonyms: Cuantitativo |
es-MX | Spanish (Mexico) | Interferón gamma estimulado por Mycobacterium tuberculosis.ESAT-6 Ag spot count: |
fr-FR | French (France) | Interféron gamma stimulé par mycobacterium tuberculosis antigène ESAT-6 spots comptés: |
it-IT | Italian (Italy) | Interferone gamma stimolato da mycobacterium tuberculosis.antigeni ESAT6 numero di spot: Synonyms: Gamma interferone stimolato da Mycobacterium tuber Interferone gamma stimolato da microbatterio della Micobatterio della tubercolosi Microbiologia Numero (conta) Punto nel tempo (episodio) Sangue |
nl-NL | Dutch (Netherlands) | Mycobacterium tuberculosis-gestimuleerde gamma-interferon ESAT-6-Ag spot count: |
pl-PL | Polish (Poland) | Stymulowany przez Mycobacterium tuberculosis interferon gamma.Liczba spotów Ag ESAT-6: Synonyms: Stymulowany przez Mycobacterium tuberculosis interferon gamma.Liczba spotów Ag ESAT-6 |
pt-BR | Portuguese (Brazil) | Mycobacterium tuberculosis estimulada gama interferon.ESAT-6 Ag contagem de ponto: |
ru-RU | Russian (Russian Federation) | Mycobacterium tuberculosis стимулированный гамма интерферон.ESAT-6 Аг пятно количество панель: Synonyms: Количественный Количество Кровь Точка во времени; |
tr-TR | Turkish (Turkey) | Mycobacterium tuberculosis uyarılmış gamma interferon.ESAT-6 Ag spot sayım: |
zh-CN | Chinese (China) | 结核分枝杆菌刺激型 gamma 干扰素.ESAT-6 抗原斑点计数: Synonyms: AFB IFN 个数; |
Example Units
Unit | Source |
---|---|
{#} | Example UCUM Units |
LOINC Terminology Service (API) using HL7® FHIR® Get Info
Requests to this service require a free LOINC username and password. Below is a sample of the possible capabilities. See the LOINC Terminology Service documentation for more information.
- CodeSystem lookup
- https:
//fhir.loinc.org/CodeSystem/$lookup?system=http: //loinc.org&code=74278-3
LOINC Copyright
Copyright © 2025 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://