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Term Description

CSF testing of GABA is used to diagnose several inherited disorders, including SSADH deficiency, GABA-T deficiency, homocarnosinosis and pyridoxal-5-phosphate dependent seizures.

Part Description

LP173713-1   Gamma aminobutyrate free and total panel
Gamma-aminobutyric acid (GABA), a primary inhibitory neurotransmitter in the brain, is synthesized from glutamate by the pyridoxine dependent enzyme glutamic acid decarboxylase (GAD). The first step in the catabolism of GABA involves degradation to succinic semialdehyde in a reaction catalyzed by GABA-transaminase (GABA-T). Succinic acid is then converted to succinic semialdehyde by the enzyme succinic semialdehyde dehydrogenase (SSADH). GABA is also present in non-neuronal tissues and may exist in peripheral and central tissues in the form of a dipeptide with histidine, as a compound known as homocarnosine. Several inherited disorders of GABA metabolism have been identified; these are SSADH deficiency, GABA-T deficiency and homocarnosinosis. The later two are extremely rare and require CSF determination of both free and total GABA. The clinical presentation of these cases may vary considerably and include psychomotor retardation, convulsions, ataxia, hypotonia, hyperflexia and delayed speech development. In addition an autosomal recessive disorder has been characterized in a group of patients with pyridoxine-dependent seizures. In these cases the presumed abnormality is due to reduced binding of pyridoxal-5-phosphate to GAD. Elevation of CSF free and total GABA are characteristic of GABA-T and SSADH deficiency, where-as low CSF GABA has been reported in pyridoxal-5-phosphate dependent seizures. Source: Regenstrief Help

Panel Hierarchy

Details for each LOINC in Panel LHC-Forms

LOINCNameR/O/CCardinalityExample UCUM Units
74439-1GABA free and total panel - Cerebrospinal Fluid
Indent72420-3Gamma aminobutyrate.free [Moles/volume] in Cerebrospinal Fluidumol/L
Indent26594-2Gamma aminobutyrate [Moles/volume] in Cerebrospinal Fluidumol/L

LOINC Names Get Info

Fully-Specified Name
Gamma aminobutyrate free and total panel:-:Pt:CSF:-:
Long Common Name
GABA free and total panel - Cerebrospinal Fluid
Short Name
GABA free+total Pnl CSF
Display Name
GABA free and total panel (CSF)
Consumer Name Alpha Get Info
Free and Total GABA Panel, Spinal fluid

Part Model Get Info

  • Component
    Gamma aminobutyrate free and total panel
    LP173713-1
    • Analyte
      Gamma aminobutyrate free and total panel
      LP173713-1
      • Component Numerator
        Gamma aminobutyrate free and total panel
        LP173713-1
        • Component Numerator Core
          Gamma aminobutyrate free and total panel
          LP173713-1
        • Component Numerator Core Suffix
          NULL
           
      • Component Denominator
        NULL
         
        • Component Denominator Core
          NULL
           
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    -
    LP6769-6
  • Time
    Pt
    LP6960-1
  • System
    CSF
    LP7156-5
    • System Core
      CSF
      LP7156-5
    • Super System
      NULL
       
  • Scale
    -
    LP7747-1
  • Method
    NULL
     

Basic Attributes

Class
PANEL.CHEM
Type
Laboratory
First Released
Version 2.46
Last Updated
Version 2.83 (MIN)
Order vs. Observation
Order
Panel Type
Panel

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)GABA volná a GABA panel:-:Časový bod:Mozkomíšní mok:-:
el-GRGreek (Greece)Πίνακας ελεύθερου & ολικού γ-αμινοβουτυρικού:-:Pt:ΕΝΥ:-:
Synonyms: - CHEM PANEL.CHEM Pt Γ-αμινοβουτυρικό Γ-αμινοβουτυρικό.ελεύθερο ΕΝΥ Πίνακας ελεύθερου & ολικού γ-αμινοβουτυρικού
es-ESSpanish (Spain)Gamma aminobutirato libre y total:Propiedades mixtas (sólo paneles):Punto temporal:Líquido Cefalorraquideo:-:
es-MXSpanish (Mexico)Panel total y libre de gamma aminobutirato:-:Punto temporal:Fluído espinal cerebral:-:
fr-FRFrench (France)Gamma aminobutyrate libre et total panel:-:Ponctuel:Liquide céphalorachidien:-:
it-ITItalian (Italy)Gamma amminobutirrato libero e totale, panel:-:Pt:LCS:-:
Synonyms: Chimica Liquido cerebrospinale Punto nel tempo (episodio) Set di prescrizione chimica
nl-NLDutch (Netherlands)gamma-aminobutyraat vrij en totaal panel:-:moment:liquor cerebrospinalis:-:
pl-PLPolish (Poland)Panel kwasu gamma-aminomasłowego wolnego i całkowitego:-:punkt w czasie:płyn mózgowo-rdzeniowy:-:
Synonyms: Kwas gamma-aminomasłowy;GABA Panel GABA wolny i całkowity Wolny kwas gamma-aminomasłowy;wolny GABA
ru-RURussian (Russian Federation)Гамма аминобутират свободный и общий панель:-:ТчкВрм:ЦСЖ:-:
Synonyms: ГАМК.свободный Гамма-аминобутират Точка во времени;Момент Цереброспинальная жидкость
zh-CNChinese (China)Gamma 氨基丁酸游离型与总计组套:-:时间点:脑脊液:-:
Synonyms: 4-氨基丁酸;GABA;Gamma 氨基丁酸（Gamma aminobutyric acid，GABA）;Gamma-氨基丁酸;G-氨基丁酸;γ氨基丁酸;γ-氨基丁酸;哌啶酸 CSF CSF;脊髓液;Cerebral spinal fluid;脑脊髓液 Gamma 氨基丁酸（γ氨基丁酸、4-氨基丁酸、GABA、Gamma-氨基丁酸、G-氨基丁酸、γ-氨基丁酸）游离型与总计组套（组合、医嘱组、套餐、套餐医嘱、医嘱套餐、组合申请、组合项目）;游离型与总 Gamma 氨基丁酸医嘱组;γ氨基丁酸游离型与总计医嘱组 全体数量 全部 共计 化学;化学检验项目;化学检验项目类;化学类;化学试验;非刺激耐受型化学检验项目;非刺激耐受型化学检验项目类;非刺激耐受型化学试验;非刺激耐受型化学试验类 医嘱套餐 医嘱套餐类 医嘱套餐组 医嘱组 医嘱组.化学试验;化学组套（组合、医嘱组、套餐、套餐医嘱、医嘱套餐、组合申请、组合项目）;化学医嘱组类;医嘱组.化学;医嘱组.化学检验项目;医嘱组类.化学;医嘱组类.化学检验项目;医嘱组类.化学试验;实验室医嘱组类.化学;实验室医嘱组类.化学检验项目;实验室医嘱组类.化学试验 医嘱组合 医嘱组合类 医嘱组套 医嘱组套类 医嘱组类 多重;多重型;多重标尺类型;多重精度类型 套餐 套餐医嘱 套餐医嘱组 套餐医嘱组类 实验室医嘱套餐 实验室医嘱套餐类 实验室医嘱组 实验室医嘱组合类 实验室医嘱组套 实验室医嘱组套类 实验室套餐医嘱组 实验室套餐医嘱组类 实验室检验项目医嘱组合类 实验室检验项目组合类 总 总和 总数 总量 总额 时刻;随机;随意;瞬间 检验医嘱组合类 检验项目医嘱组合类 检验项目组合类 氨基-n-丁酸 氨基丁酸盐 氨基丁酸酯 汇总 游离 游离型 4-氨基丁酸;GABA;Gamma 氨基丁酸（Gamma aminobutyric acid，GABA）;游离型 Gamma-氨基丁酸;游离型 G-氨基丁酸;游离型γ氨基丁酸;游离型γ-氨基丁酸;哌啶酸 组 组合 组合医嘱 组合类 组套 脊液 脊髓液 脑脊液（Cerebral spinal fluid，CSF） 脑脊髓液 非蛋白结合型 非蛋白质结合型

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=74439-1
Questionnaire definition
https://fhir.loinc.org/Questionnaire/?url=http://loinc.org/q/74439-1