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Term Description

The Carba NP (Carbapenemase Nordmann-Poirel) test rapidly (<2 hrs) detects carbapenemase production in isolates of Enterobacteriaceae and Pseudomonas aeruginosa. Carbapenemases are detected and can be differentiated by the CarbaNP test when the test isolate produces the enzyme (in the absence of a chemical inhibitor) that hydrolyzes imipenem (a carbapenem antibiotic) into the carboxylic form of the antibiotic, thereby lowering the pH of the reaction solution which contains phenol red indicator. The acidification changes the red color of the reaction solution to orange-yellow color (positive result) that can be visualized easily with the naked eye. Carba NP testing can detect the following carbapenemase types: Klebsiella pneumoniae carbapenemase (KPC; Ambler class A); Verona integron-encoded metallo-β-lactamase (VIM), imipenemase (IMP), New Delhi metallo-β-lactamase (NDM) (all Ambler class B); and oxacillinase-48 (OXA-48; Ambler class D).

For this test, each test isolate is inoculated into 4 reaction wells or tubes: one without any antibiotic or chemical inhibitor against carbapenemases, one containing imipenem without any chemical inhibitor, one containing impenem and tazobactam (which inhibits KPC carbapenemases), one containing imipenem and EDTA (which inhibits VIM, IMP, and NDM carbapenemases). Based on the presence and absence of color change among the 4 reaction wells or tubes, one can differentiate among the 3 classes of carbapenemases. However, differentiation is not possible with this test in isolates that produce more than one class of carbapenemases simultaneously.

Part Description

LP105133-5   Carbapenemase
Carbapenems are famously stable to AmpC β-lactamases and extended-spectrum-β-lactamases. Carbapenemases are a diverse group of β-lactamases that are active not only against the oxyimino-cephalosporins and cephamycins but also against the carbapenems. Carbapenemases were formerly believed to derive only from classes A, B, and D, but a class C carbapenemase has been described. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Carbapenemase

LOINC Names Get Info

Fully-Specified Name
Carbapenemase:Type:Pt:Isolate:Nom:Carbapenemase Nordmann-Poirel
Long Common Name
Carbapenemase [Type] in Isolate by Carba NP
Short Name
Carbapenemase Islt
Display Name
Carbapenemase Carba NP Nom (Isol)
Consumer Name Alpha Get Info
Carbapenemase

Part Model Get Info

  • Component
    Carbapenemase
    LP105133-5
    • Analyte
      Carbapenemase
      LP105133-5
      • Component Numerator
        Carbapenemase
        LP105133-5
        • Component Numerator Core
          Carbapenemase
          LP105133-5
        • Component Numerator Core Suffix
          NULL
           
      • Component Denominator
        NULL
         
        • Component Denominator Core
          NULL
           
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    Type
    LP6886-8
  • Time
    Pt
    LP6960-1
  • System
    Isolate
    LP7370-2
    • System Core
      Isolate
      LP7370-2
    • Super System
      NULL
       
  • Scale
    Nom
    LP7750-5
  • Method
    Carbapenemase Nordmann-Poirel
    LP182452-5

Example Answer List: LL2781-4

Source: Mayo Medical Laboratories
AnswerCodeScoreAnswer ID
KPC carbapenemase detectedLA20670-8
VIM, IMP, and/or NDM carbapenemase(s) detectedLA20671-6
OXA-48 carbapenemase detectedLA20672-4
Carbapenemases detected, but unable to determine the type present, and more than one type of carbapenamase may be present.LA20673-2

Basic Attributes

Class
MICRO
Type
Laboratory
First Released
Version 2.48
Last Updated
Version 2.73 (MIN)
Order vs. Observation
Both
Common Test Rank Get Info
17381

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)Karbapenemáza:Typ:Časový bod:Izolát:Nominální:Test Carba NP
el-GRGreek (Greece)Καρβαπενεμάση:Type:Pt:Απομονωμένο στέλεχος:Nom:Καρβαπενεμάση Nordmann-Poirel
Synonyms: MICRO Nom Pt Type Απομονωμένο στέλεχος Καρβαπενεμάση Καρβαπενεμάση Nordmann-Poirel
es-ESSpanish (Spain)Carbapenemasa:Tipo:Punto temporal:Aislado:Nom:Carba NP
es-MXSpanish (Mexico)Carbapenemasa:Tipo:Punto temporal:Aislado:Nominal:Carba NP
fr-FRFrench (France)Carbapénèmase:Type:Ponctuel:Isolat:Résultat nominal:Carbapénémase Nordmann-Poirel
it-ITItalian (Italy)Carbapenemasi:Tipo:Pt:Isolato:Nom:Carbapenemasi Nordmann-Poirel
Synonyms: Carba NP Microbiologia Punto nel tempo (episodio)
nl-NLDutch (Netherlands)carbapenemase:type:moment:isolaat:nominaal:Carba NP
Synonyms: Carbapenemase Nordmann-Poirel
pl-PLPolish (Poland)Karbapenemaza:typ:punkt w czasie:izolat:skala nominalna:karbapenemaza Nordmanna i Porela
Synonyms: wynik kategorialny
pt-BRPortuguese (Brazil)Carbapenemase:Tipo:Pt:Isolado:Nom:Carbapenemase Nordmann-Poirel
zh-CNChinese (China)碳青霉烯酶:类型:时间点:分离株:名义型:碳青霉烯酶 Nordmann-Poirel 试验
Synonyms: 分离物;分离菌;分离菌株;隔离种群 分类型应答;分类型结果;名义性;名称型;名词型;名词性;标称性;没有自然次序的名义型或分类型应答 型 微生物学;微生物学试验;微生物学试验（培养、DNA、抗原及抗体） 时刻;随机;随意;瞬间 碳青霉烯酶（碳青黴烯酶、碳青霉烯水解酶） Nordmann-Poirel 试验;Carba NP 试验;碳青霉烯酶 NP 试验;Carbapenemase Nordmann-Poirel Test;Carba NP 确证试验 碳青黴烯酶;碳青霉烯水解酶

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=74676-8