LOINC
Version 2.67

74680-0Amphetamine [Presence] in Saliva (oral fluid) by Confirmatory methodActive

Part Descriptions

LP18868-7   Amphetamine
Amphetamine (AMPH) is a drug that stimulates both the central and peripheral nervous systems and is used to treat attention-deficit/hyperactivity disorder, narcolepsy and obesity. [PMID: 17209801] AMPH increases extracellular monoamine neurotransmitters in the brain including dopamine, serotonin and norepinephrine. AMPH promotes presynaptic release of the neurotransmitters rather than blocking their re-uptake. Physiological responses to AMPH use include increased blood pressure, increased heart rate, increased body temperature, relaxed bronchial muscle and depressed appetite. Abuse of AMPH can cause powerful psychological dependence, tolerance, mild physical dependence associated with tachycardia, restlessness, irritability, insomnia, personality changes and an intense form of chronic intoxication psychosis similar to schizophrenia. Long-term users of AMPH can experience depression, impaired memory and motor skills most likely due to a drop in dopamine transporters and damage to dopaminergic and serotonergic neurons. Excretion of AMPH is in the urine and the rate of elimination is dependent on the pH of the urine. Urine with an alkaline pH has an excretion rate of 18-34 hours while that of acid urine is 7-14 hours.(Tietz Fundamentals of Clinical Chemistry and Molecular Diagnostics, Seventh Edition; Carl A. Burtis; David E. Bruns) Source: Regenstrief LOINC

LP7565-7   Saliva
Saliva is produced primarily by the parotid, submaxillary, and sublingual glands. It is secreted at the rate of 0-3 milliliters per minute which is affected by various factors including anxiety, hydration and hunger. Oral fluid is broadly used to test for drugs of abuse in employment and forensic settings, and is especially useful since it is difficult to adulterate, is quick and is non-invasive. Oral fluid is used to test a variety of analytes, including to test alcohol, HIV and other antibodies, therapeutic drugs and steroids, but its primary use is to test for drugs of abuse including amphetamines, cocaine and metabolites, opioids, methadone, cannabis and heroin. [PMID: 17268583] Source: Regenstrief LOINC

LP262420-5   Saliva DRUG/TOX
Oral fluid (or saliva) is produced primarily by the parotid, submaxillary, and sublingual glands. It is secreted at the rate of 0-3 milliliters per minute which is affected by various factors including anxiety, hydration and hunger. Oral fluid is broadly used to test for drugs of abuse in employment and forensic settings, and is especially useful since it is difficult to adulterate, is quick and is non-invasive. Oral fluid is used to test a variety of analytes, including to test alcohol, HIV and other antibodies, therapeutic drugs and steroids, but its primary use is to test for drugs of abuse including amphetamines, cocaine and metabolites, opioids, methadone, cannabis and heroin. The test procedures that use oral fluid for drug screening are usually similar to those for other specimens but adapted for oral fluid. Oral fluid is broadly used to test for drugs of abuse in employment and forensic settings, and is especially useful since it is difficult to adulterate, is quick and is non-invasive. Drugs present in oral fluid are often the parent drug rather than a metabolite and tests kits reflect those differences. Concentrations of cocaine, amphetamines and some opioids in oral fluid are either similar or higher than concentrations in plasma. The concentration of tetrahydrocannabinol (THC) in oral fluid is similar to that of plasma, though in cases where recent ingestion has occurred, levels may be higher due to the significant local absorption in the oral cavity. Confirmatory testing on oral fluid using liquid chromatography-mass spectrometry (LC-MS) is highly sensitive and specific even on relatively small sample sizes. An increased understanding of pharmacokinetics in oral fluid has flourished inover the last ten years has allowed the correlation of . As a result, the concentrations of various drugs in oral fluid have been correlated to blood concentrations and the effects they have on the individual. [PMID: 17268583] Source: Regenstrief LOINC

Fully-Specified Name

Component
Amphetamine
Property
PrThr
Time
Pt
System
Saliva
Scale
Ord
Method
Confirm

Additional Names

Short Name
Amphet Sal Ql Cfm
Display Name
Amphetamine Confirm Ql (Sal)

Basic Attributes

Class
DRUG/TOX
Type
Laboratory
First Released
Version 2.48
Last Updated
Version 2.56
Change Reason
The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation
Both

Example Answer List LL360-9

Source: Regenstrief Institute

Answer Code Score Answer ID
Positive Copyright http://snomed.info/sct ID:10828004 Positive (qualifier value) LA6576-8
Negative Copyright http://snomed.info/sct ID:260385009 Negative (qualifier value) LA6577-6

Member of these Groups

LG37607-5 Amphetamine|ANYProp|ANYTm|ANYSys|ANYMeth

Language Variants Get Info

zh-CNChinese (CHINA)
苯丙胺:存在情况或阈值:时间点:唾液:序数型:毒理学确认试验
nl-NLDutch (NETHERLANDS)
amfetamine:aanwezigheid:moment:speeksel:ordinaal:bevestiging
et-EEEstonian (ESTONIA)
Amfetamiin:PrThr:Pt:Sal:Ord:Kinnitav
fr-BEFrench (BELGIUM)
Amphétamine:PrThr:Temps ponctuel:Salivaire:Ordinal:Confirmé
fr-CAFrench (CANADA)
Amphétamine:Présence-Seuil:Temps ponctuel:Salivaire:Ordinal:Confirmé
fr-FRFrench (FRANCE)
Amphétamine:Présence/Seuil:Ponctuel:Salive:Qualitatif:Confirmation
it-ITItalian (ITALY)
Anfetamina:PrThr:Pt:Saliva:Ord:Conferma
pt-BRPortuguese (BRAZIL)
Anfetamina:Limiar:Pt:Saliva:Ord:Confirmatório
ru-RURussian (RUSSIAN FEDERATION)
Амфетамин:PrThr:ТчкВрм:Слюна:Пор:Подтверждать
es-ESSpanish (SPAIN)
Anfetamina:PrThr:Punto temporal:Saliva:Ord:Confirmatorio
tr-TRTurkish (TURKEY)
Amfetamin:MevcEşik:Zmlı:Tükürük:Srl:Onay

LOINC FHIR® API Example - CodeSystem Request Get Info

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=74680-0