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Term Description

This is a quantitative reverse transcriptase real-time PCR for the Porcine Epidemic Diarrhea Viurs (PEDv) RNA. This code is intended to represent the most conserved available target specific to PEDv. If more strain-specific or gene-specific tests are developed, they would specify the gene or strain. The same test is used on feces, various tissue swabs, feed samples, and environmental samples.

Part Description

LP182479-8   Porcine epidemic diarrhea virus
Porcine Epidemic Diarrhea Virus (PEDv) is a large-enveloped RNA virus, which is a member of the genus Alphacoronavirus within the Coronaviridae family. The complete PEDv genome consists of 5 gene segments: open reading frame 1 (ORF1), spike (S), envelope (E), membrane (M), and nucleocapsid (N). It is encapsulated by a single N protein. The S protein contributes to the stimulation of neutralizing antibodies in the infected host. Its association to adapted growth in vitro and attenuation in vivo lends itself to use for genetic comparison among PEDV isolates and effective vaccines. The M protein is required for assembly and can also induce the production of virus-neutralizing antibodies. The E protein contributes to coronavirus budding. The N protein has functions associated with viral replication and pathogenesis.
PEDv causes viral enteritis, which leads to the destruction of villus enterocytes in pigs of all ages. It is spread by the ingestion of feces from infected pigs, resulting in vomiting, watery diarrhea, dehydration, and high mortality, especially in nursery piglets. Disease caused by PEDv is clinically similar to that caused by Transmissible gastroenteritis coronavirus (TGEV) PMID: 26689811
At least two PEDv strains have been identified in the USA: the US PEDv prototype and S INDEL variant. The INDEL variant PEDv strain has insertions and deletions (INDELs) in the spike (S) gene. PMID: 25279722 The INDEL strain is related to milder clinical signs than prototype strains. PMID: 24750580 PMID: 26748596 The genomic differences in the S gene between the US PEDv prototype and INDEL variant may be responsible for the virulence differences. Potential targets when testing for PEDv RNA include the nucleocapsid protein (N) gene and the ~2500 bp fragment of the S-gene. Source: Regenstrief LOINC

LOINC Names Get Info

Fully-Specified Name
Porcine epidemic diarrhea virus RNA:ThreshNum:Pt:XXX:Qn:Probe.amp.tar
Long Common Name
Porcine epidemic diarrhea virus RNA [Cycle Threshold #] in Specimen by NAA with probe detection
Short Name
PEDv RNA Ct Spec Qn NAA+probe
Display Name
Porcine epidemic diarrhea virus RNA NAA+probe (Specimen) [ThreshNum]
Consumer Name Alpha Get Info
Porcine Epidemic Diarrhea virus, Specimen

Part Model Get Info

  • Component
    Porcine epidemic diarrhea virus RNA
    LP182480-6
    • Analyte
      Porcine epidemic diarrhea virus RNA
      LP182480-6
      • Component Numerator
        Porcine epidemic diarrhea virus RNA
        LP182480-6
        • Component Numerator Core
          Porcine epidemic diarrhea virus
          LP182479-8
        • Component Numerator Core Suffix
          RNA
          LP32423-3
      • Component Denominator
        NULL
         
        • Component Denominator Core
          NULL
           
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    ThreshNum
    LP188772-0
  • Time
    Pt
    LP6960-1
  • System
    XXX
    LP7735-6
    • System Core
      XXX
      LP7735-6
    • Super System
      NULL
       
  • Scale
    Qn
    LP7753-9
  • Method
    Probe.amp.tar
    LP6464-4

Basic Attributes

Class
MICRO
Type
Laboratory
First Released
Version 2.48
Last Updated
Version 2.69 (MIN)
Change Reason
Changed property from 'ThresNum' to clarify the property name.
Order vs. Observation
Both

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)Virus epidemické prasečí průjmové nemoci (PED) RNA:Prahová hodnota:Časový bod:XXX:Kvantitativní:Amplifikace nukleových kyselin s detekcí sondou
el-GRGreek (Greece)Ιός επιδημικής διάρροιας των χοίρων RNA:ThreshNum:Pt:XXX:Qn:Ανιχνευτής.ενίσχυση.στόχου
Synonyms: MICRO Pt Qn RNA ThreshNum XXX Ανιχνευτής Ανιχνευτής.ενίσχυση Ανιχνευτής.ενίσχυση.στόχου Ιός Ιός επιδημικής διάρροιας των χοίρων Των χοίρων
es-ESSpanish (Spain)Virus de la diarrea epidémica porcina RNA:ThreshNnum:Punto temporal:XXX:Qn:Sonda con amplificación dirigida
Synonyms: Cuantitativo
es-MXSpanish (Mexico)ARN del virus de la diarrea epidémica porcina:ThreshNum:Punto temporal:XXX:Cuantitativo:Amplificación de ácidos nucleicos con detección de sonda
it-ITItalian (Italy)Virus della diarrea epidemica suina RNA:Thresnum:Pt:XXX:Qn:Sonda.amp.tar
Synonyms: Limite di soglia Microbiologia Punto nel tempo (episodio) Sonda con amplificazione Sonda con amplificazione del target Sonda di DNA Virus PED
nl-NLDutch (Netherlands)'porcine' epizoötisch diarreevirus RNA:drempelwaarde nummer:moment:XXX:kwantitatief:probe-detectie
Synonyms: epizoötisch diarreevirus van varken porcine probe.amp.tar
pl-PLPolish (Poland)Wirus epidemicznej biegunki świń RNA:wartość progowa:punkt w czasie:XXX:ilościowy:sonda.amplifikacja.cel
Synonyms: amplifikacja kwasu nukleinowego z detekcją za pomocą sondy amplifikacja z detekcją za pomocą sondy
tr-TRTurkish (Turkey)Porsin epidemik diyare virüsü RNA:EşikDeğ:Zmlı:XXX:Kant:Prob.amf.hdf
Synonyms: Eşik Değer
zh-CNChinese (China)猪流行性腹泻病毒 RNA:阈值循环圈数:时间点:XXX:定量型:探针法.基因扩增.靶向
Synonyms: 下痢;泄泻;下利;泻肚 不明的;其他;将在相应消息内其他部分之中加以详细说明;未作详细说明的;未作说明的;未做说明的标本;未加规定的;未加说明的标本;杂项 传染毒;传染毒素;滤过性病原体;病毒类;过滤性病原体 借助扩增的探针方法;借助扩增的探针法;探针法.扩增 借助靶向扩增的探针方法;借助靶向扩增的探针法;探针法.扩增.靶向 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 微生物学;微生物学试验;微生物学试验（培养、DNA、抗原及抗体） 扩增型 扩增性 时刻;随机;随意;瞬间 核糖核酸;Ribonucleic acid 猪传染性腹泻病毒;PEDv 猪的 猪科 猪科的 界值数;界限数;阀值数;临界值数;阈值循环数;阈值数;达到阈值时的循环圈数;荧光信号到达设定阈值时所经历的循环数;Ct 值;Cycle threshold;循环阈值 经过扩增的 脱氧核糖核酸探针

Example Units

UnitSource
{Ct_value}Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=74752-7