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Part Descriptions

LP173714-9   Medium-chain Acyl CoA dehydrogenase
Acyl-CoA dehydrogenases are a class of enzymes that function to catalyze the initial step in each cycle of fatty acid β -oxidation in the mitochondria of cells. Their action results in the introduction of a trans double-bond between C2 and C3 of the acyl-CoA thioester substrate. FAD is a required co-factor in the mechanism in order for the enzyme to bind to its appropriate substrate. Acyl-CoA dehydrogenases can be categorized into three distinct groups based on their specificity for short-, medium-, or long-chain fatty acid acyl-CoA substrates. While different dehydrogenases target fatty acids of varying chain length, all types of acyl-CoA dehydrogenases are mechanistically similar. Differences in the enzyme occur based on the location of the active site along the amino acid sequence. Acyl-CoA dehydrogenases are an important class of enzymes in mammalian cells because of their role in metabolizing fatty acids present in ingested food materials. This enzyme's action represents the first step in fatty acid metabolism (the process of breaking long chains of fatty acids into acetyl CoA molecules). Deficiencies in these enzymes are linked to genetic disorders involving fatty acid oxidation (i.e. metabolic disorders). Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Acyl-CoA dehydrogenase

LP173714-9   Medium-chain Acyl CoA dehydrogenase
Medium-chain acyl-CoA dehydrogenase (MCAD) deficiency is a condition that prevents the body from converting certain fats to energy, particularly during periods without food (fasting). Signs and symptoms of MCAD deficiency typically appear during infancy or early childhood and can include vomiting, lack of energy (lethargy), and low blood sugar (hypoglycemia). In rare cases, symptoms of this disorder first appear during adulthood. People with MCAD deficiency are at risk for serious complications such as seizures, breathing difficulties, liver problems, brain damage, coma, and sudden death. Problems related to MCAD deficiency can be triggered by periods of fasting or by illnesses such as viral infections. This disorder is sometimes mistaken for Reye syndrome, a severe disorder that may develop in children while they appear to be recovering from viral infections such as chicken pox or flu. Most cases of Reye syndrome are associated with the use of aspirin during these viral infections. Source: Genetic Home Reference, National Library of Medicine, MCAD deficiency

LOINC Names Get Info

Fully-Specified Name
Medium-chain Acyl CoA dehydrogenase:CCnt:Pt:WBC:Qn:
Long Common Name
Medium-chain Acyl CoA dehydrogenase [Enzymatic activity/mass] in Leukocytes
Short Name
MCAD WBC-cCnt
Display Name
Medium-chain Acyl CoA dehydrogenase (WBC) [Catalytic activity/Mass]
Consumer Name Alpha Get Info
Medium-chain acyl coA dehydrogenase, White blood cells

Part Model Get Info

  • Component
    Medium-chain Acyl CoA dehydrogenase
    LP173714-9
    • Analyte
      Medium-chain Acyl CoA dehydrogenase
      LP173714-9
      • Component Numerator
        Medium-chain Acyl CoA dehydrogenase
        LP173714-9
        • Component Numerator Core
          Medium-chain Acyl CoA dehydrogenase
          LP173714-9
        • Component Numerator Core Suffix
          NULL
           
      • Component Denominator
        NULL
         
        • Component Denominator Core
          NULL
           
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    CCnt
    LP6790-2
  • Time
    Pt
    LP6960-1
  • System
    WBC
    LP7720-8
    • System Core
      WBC
      LP7720-8
    • Super System
      NULL
       
  • Scale
    Qn
    LP7753-9
  • Method
    NULL
     

Basic Attributes

Class
CHEM
Type
Laboratory
First Released
Version 2.48
Last Updated
Version 2.48 (MIN)
Order vs. Observation
Both

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)Acyl-CoA-dehydrogenáza se středně dlouhým řetězcem:Katalytický obsah:Časový bod:Leukocyty:Kvantitativní:
el-GRGreek (Greece)Ακυλο-CoA αφυδρογονάση μεσαίας αλύσου:CCnt:Pt:Αριθμός λευκών αιμοσφαιρίων:Qn:
Synonyms: CCnt CHEM Pt Qn Ακυλο-CoA αφυδρογονάση Ακυλο-CoA αφυδρογονάση μεσαίας αλύσου Αριθμός λευκών αιμοσφαιρίων
es-ESSpanish (Spain)Acil-CoA Deshidrogenasa de cadena media:Contenido catalítico:Punto temporal:Células sanguineas blancas:Qn:
Synonyms: Cuantitativo
es-MXSpanish (Mexico)Acil CoA deshidrogenasa de cadena media:Contenido catalítico:Punto temporal:células blancas de la sangre:Cuantitativo:
fr-FRFrench (France)Acyl CoA déshydrogénase à chaîne moyenne:Catalytique/Masse:Ponctuel:Leucocytes:Numérique:
it-ITItalian (Italy)Deficit di acil-CoA deidrogenasi a catena media:CCnt:Pt:WBC:Qn:
Synonyms: Chimica Contenuto Catalitico Globuli bianchi Punto nel tempo (episodio)
nl-NLDutch (Netherlands)medium-keten Acyl-CoA-dehydrogenase:enzymatische activiteit/massa:moment:leukocyten:kwantitatief:
Synonyms: witte bloedcellen
ru-RURussian (Russian Federation)Средняя длина цепи Ацил КоА дегидрогеназа:КаталСод:ТчкВрм:Лейкоциты:Колич:
Synonyms: Каталитическое содержание Количественный Точка во времени;Момент
tr-TRTurkish (Turkey)Orta-zincir Açil KoA dehidrojenaz:Ktlİçrk:Zmlı:Lökosit:Kant:
Synonyms: Orta-zincir Açil KoA dehidrogenaz WBC
zh-CNChinese (China)中链脂酰基 CoA 脱氢酶:催化含量:时间点:白细胞:定量型:
Synonyms: AcdA;酰基辅酶 A 脱氢酶 WBC;WBCs;白血球;白血细胞 中链脂酰基辅酶A脱氢酶;中链脂酰辅酶A脱氢酶;中链脂酰 CoA 脱氢酶 催化含量(单位质量);单位质量的酶单位数 化学;化学检验项目;化学检验项目类;化学类;化学试验;非刺激耐受型化学检验项目;非刺激耐受型化学检验项目类;非刺激耐受型化学试验;非刺激耐受型化学试验类 去氢酶 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 时刻;随机;随意;瞬间

Example Units

UnitSource
nmol/min/mg{protein}Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=74891-3