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Part Description

LP14372-4   Coproporphyrin 3
Coproporhyrin III is a porphyrin metabolite arising from heme synthesis. Porphyrins are pigments found in both animal and plant life. Coproporphyrin III is a tetrapyrrole dead-end product from the spontaneous oxidation of the methylene bridges of coproporphynogen, arising from heme synthesis and secreted in feces and urine. Increased levels of coproporphyrins can indicate congenital erythropoietic porphyria or sideroblastic anaemia. Porphyria is a pathological state characterised by abnormalities of porphyrin metabolism and results in the excretion of large quantities of porphyrins in the urine and in extreme sensitivity to light. A large number of factors are capable of increasing porphyrin excretion, owing to different and multiple causes and etiologies: 1) the main site of the chronic hepatic porphyria disease process concentrates on the liver, 2) a functional and morphologic liver injury is almost regularly associated with this chronic porphyria, 3) the toxic form due to occupational and environmental exposure takes mainly a subclinical course. Hepatic factors includes disturbance in coproporphyrinogen metabolism, which results from inhibition of coproporphyrinogen oxidase as well as from the rapid loss from, and diminished utilization of coproporphyrinogen in the hepatocytes, which may also explain why coproporphyrin, its autoxidation product, predominates physiologically in the urine; decreased biliary excretion of coproporphyrin leading to a compensatory urinary excretion, so that the coproporphyrin ring isomer ratio (1:III) becomes a sensitive index for impaired liver function and intrahepatic cholestasis; and disturbed activity of hepatic uroporphyrinogen decarboxylase. In itself, secondary coproporphyrinuria is not associated with porphyria symptoms of a hepatologic-gastroenterologic, neurologic, or dermatologic order, even though coproporphyrinuria can occur with such symptoms. PMID: 3327428 Copyright Copyright ©2005-2009 Genome Alberta (Reference to original publication: Wishart DS, Knox C, Guo AC, et al. HMDB: a knowledgebase for the human metabolome. Nucleic Acids Res. 2009 37(Database issue):D603-610.) Source: Human Metabolome Database, Corproporphyrin III

LOINC Names Get Info

Fully-Specified Name
Coproporphyrin 3/Coproporphyrin.total:SFr:24H:Urine:Qn:
Long Common Name
Coproporphyrin 3/Coproporphyrin.total in 24 hour Urine
Short Name
Copro3/Copro total 24h SFr Ur
Display Name
Coproporphyrin 3 (24H U) [Molar fraction]
Consumer Name Alpha Get Info
Coproporphyrin 3, Urine

Part Model Get Info

  • Component
    Coproporphyrin 3/Coproporphyrin.total
    LP285803-5
    • Analyte
      Coproporphyrin 3/Coproporphyrin.total
      LP285803-5
      • Component Numerator
        Coproporphyrin 3
        LP14372-4
        • Component Numerator Core
          Coproporphyrin 3
          LP14372-4
        • Component Numerator Core Suffix
          NULL
           
      • Component Denominator
        Coproporphyrin.total
        LP32031-4
        • Component Denominator Core
          Coproporphyrin.total
          LP32031-4
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    SFr
    LP6866-0
  • Time
    24H
    LP6924-7
  • System
    Urine
    LP7681-2
    • System Core
      Urine
      LP7681-2
    • Super System
      NULL
       
  • Scale
    Qn
    LP7753-9
  • Method
    NULL
     

Basic Attributes

Class
CHEM
Type
Laboratory
First Released
Version 2.48
Last Updated
Version 2.48 (MIN)
Order vs. Observation
Both

Member of these Panels

LOINCLong Common Name
74910-1Porphyrin fractions and creatinine panel [Molar ratio] - 24 hour Urine

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)Koproporfyrin 3/koproporfyrin.celkový:Látkový podíl:24 hodin:Moč:Kvantitativní:
el-GRGreek (Greece)Κοπροπορφυρίνη 3/Κοπροπορφυρίνη.ολική:SFr:24H:Ούρα:Qn:
Synonyms: 24H CHEM Qn SFr Κοπροπορφυρίνη Κοπροπορφυρίνη 3 Κοπροπορφυρίνη.ολική Ούρα
es-ESSpanish (Spain)Coproporfirina 3/Coproporfirina total:Fraccion de sustancia:24 horas:Orina:Qn:
Synonyms: Cuantitativo
es-MXSpanish (Mexico)Coproporfirina 3 / Coproporfirina total:Fracción de sustancia:24H:Orina:Cuantitativo:
et-EEEstonian (Estonia)Koproporfüriin 3/koproporfüriin.üld:SFr:24 tunni:U:Qn:
Synonyms: Aine fraktsioon Kvantitatiivne Uriin
fr-FRFrench (France)Coproporphyrine 3/coproporphyrine totale:Fraction molaire:24H:Urine:Numérique:
it-ITItalian (Italy)Coproporfirina 3/Coproporfirina.totale:SFr:24h:Urine:Qn:
Synonyms: 24 Ore Chimica Frazione di Sostanza
nl-NLDutch (Netherlands)coproporfyrine 3/coproporfyrine.totaal:stoffractie:24 uur:urine:kwantitatief:
Synonyms: 24U
ru-RURussian (Russian Federation)Копропорфирин 3/Копропорфирин.общий:МольДол:24 часа:Моча:Колич:
Synonyms: Количественный Мольная доля;Молярная доля
tr-TRTurkish (Turkey)Koproporfirin 3/Koproporfirin.total:SubFr:24Sa:İdrar:Kant:
zh-CNChinese (China)粪卟啉 III/粪卟啉.总计:物质的量分数:24小时:尿液:定量型:
Synonyms: 1天;1日;24.0小时;一天;一日;二十四个小时;二十四小时 Ⅲ Copro;Coproporph;四羧基卟啉 Copro3;粪卟啉 3;粪卟啉Ⅲ III 三 克分子分数;摩尔分数 全体数量 全部 共计 化学;化学检验项目;化学检验项目类;化学类;化学试验;非刺激耐受型化学检验项目;非刺激耐受型化学检验项目类;非刺激耐受型化学试验;非刺激耐受型化学试验类 叁 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 尿;小便;下泉 总 总和 总数 总粪卟啉 总量 总额 汇总

Example Units

UnitSource
%Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=75000-0