75011-7

t(15;17)(q24.1;q21.1)(PML,RARA) fusion transcript [Presence] in Bone marrow by Molecular genetics method

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Part Description

LP150268-3 t(15;17)(q24.1;q21.1)(PML,RARA)
The fusion of promyelocytic leukemia (PML, chromosome 15q24.1) and retinoic acid receptor alpha (RARA, chromosome 17q21.1) genes occurs due to a chromosomal translocation. The fused genes can be detected by various molecular techniques, including FISH and real-time quantitative polymerase chain reaction (RT-qPCR). The test is used to diagnose Acute Promyelocytic Leukemia (APL), detect residual or recurrent APL, and to monitor PML-RARA levels in patients with APL. The assay can be done on whole blood (plasma or cell-based) and bone marrow. Long, variant and/or short isoforms of PML-RARA fusion transcripts may be identified. The ratio of PML-RARA fusion transcript to a control gene (e.g. ABL1) may be reported for positive samples. Source: Regenstrief LOINC

Fully-Specified Name

Component: t(15;17)(q24.1;q21.1)(PML,RARA) fusion transcript
Property: PrThr
Time: Pt
System: Bone mar
Scale: Ord
Method: Molgen

Additional Names

Short Name: t(15;17)(PML,RARA) Mar Ql
Display Name: t(15;17)(q24.1;q21.1)(PML,RARA) fusion transcript Molgen Ql (BM)
Consumer Name Alpha Get Info: t(15;17)(q24.1;q21.1)(PML,RARA) fusion transcript analysis, Bone marrow

Example Answer List: LL360-9

Source: Regenstrief Institute

Answer	Code	Score	Answer ID
PositiveCopyright http://snomed.info/sct ID:10828004 Positive (qualifier value)			LA6576-8
NegativeCopyright http://snomed.info/sct ID:260385009 Negative (qualifier value)			LA6577-6

Basic Attributes

Class: MOLPATH
Type: Laboratory
First Released: Version 2.48
Last Updated: Version 2.56
Change Reason: The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation: Both

Language Variants Get Info

Tag	Language	Translation
es-ES	Spanish (Spain)	t(15;17)(q24.1;q21.1)(PML,RARA) Tránscritos de fusión:PrThr:Punto temporal:Médula ósea:Ord:Genética molecular
es-MX	Spanish (Mexico)	t (15; 17) (q24.1; q21.1) (PML, RARA) transcripción de fusión:Presencia o umbral:Punto temporal:Médula ósea:Ordinal:Genética molecular
fr-CA	French (Canada)	t(15;17)(q24.1;q21.1)(PML,RARA) transcrit de fusion:Présence-Seuil:Temps ponctuel:Moelle osseuse:Ordinal:Molgen
fr-FR	French (France)	t(15;17)(q24.1;q21.1)(PML,RARA) transcrit de fusion:Présence/Seuil:Ponctuel:Moelle osseuse:Qualitatif:Biologie moléculaire
it-IT	Italian (Italy)	t(15;17)(q24.1;q21.1)(PML,RARA), trascritto di fusione:PrThr:Pt:Mid oss:Ord:Molgen Synonyms: Genetica molecolare Midollo osseo Patologia molecolare Presenza o Soglia Punto nel tempo (episodio)
nl-NL	Dutch (Netherlands)	t(15;17)(q24.1;q21.1)(PML,RARA) fusietranscript:aanwezigheid:moment:beenmerg:ordinaal:moleculair genetisch onderzoek Synonyms: molgen
pt-BR	Portuguese (Brazil)	t(15;17)(q24.1;q21.1)(PML,RARA) transcrição de fusão::Pt:MedOssea:Ord:Genética molecular
ru-RU	Russian (Russian Federation)	t(15;17)(q24.1;q21.1)(PML,RARA) слияния транскрипт:PrThr:ТчкВрм:Костный мозг:Пор:МолГен Synonyms: Порядковый Промиелоцитарный лейкоз Точка во времени;Момент химерная РНК, закодированная слитым геном
tr-TR	Turkish (Turkey)	t(15;17)(q24.1;q21.1)(PML,RARA) füzyon transkript:MevcEşik:Zmlı:Kem il:Srl:Molgen Synonyms: Mevcut
zh-CN	Chinese (China)	t(15;17)(q24.1;q21.1)(PML,RARA) 融合转录物:存在情况或阈值:时间点:骨髓:序数型:分子遗传学类实验室方法 Synonyms: MYL NR1B1 PML-1 PML-2 PML-3 PML-3B PML-X RAR alpha 型 RAR α型 RARalpha RARα 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型分子病理学;分子病理学试验分子遗传学;分子遗传学方法;分子遗传学类方法;分子遗传学类检验方法;包括 RFL、PCR 及其他方法在内，用于在分子基础上检测遗传属性的方法的大类;聚合酶链反应;聚合酶链式反应前髓细胞白血病存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值）早幼粒细胞性白血病早幼粒细胞白血病早幼粒细胞白血病（Promyelocytic leukemia，PML）时刻;随机;随意;瞬间易位(15;17)(q24.1;q21.1)(PML,RARA) 融合转录物（转录本、转录产物、转录子、转录）;融合基因转录本;融合转录视黄酸受体 alpha 视黄酸受体 alpha（Retinoic acid receptor alpha，RARA，RARalpha，RAR alpha）视黄酸受体 α 骨骼;骨头髓

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