75024-0

Coproporphyrin 1/Porphyrins.total in Stool

Active

Part Description

LP18633-5 Coproporphyrin 1
Coproporhyrin I is a porphyrin metabolite arising from heme synthesis. Porphyrins are pigments found in both animal and plant life. Coproporphyrin I is a tetrapyrrole dead-end product from the spontaneous oxidation of the methylene bridges of coproporphynogen, arising from heme synthesis and secreted in feces and urine. Increased levels of coproporphyrins can indicate congenital erythropoietic porphyria or sideroblastic anaemia. Porphyria is a pathological state characterised by abnormalities of porphyrin metabolism and results in the excretion of large quantities of porphyrins in the urine and in extreme sensitivity to light. A large number of factors are capable of increasing porphyrin excretion, owing to different and multiple causes and etiologies: 1) the main site of the chronic hepatic porphyria disease process concentrates on the liver, 2) a functional and morphologic liver injury is almost regularly associated with this chronic porphyria, 3) the toxic form due to occupational and environmental exposure takes mainly a subclinical course. Hepatic factors includes disturbance in coproporphyrinogen metabolism, which results from inhibition of coproporphyrinogen oxidase as well as from the rapid loss from, and diminished utilization of coproporphyrinogen in the hepatocytes, which may also explain why coproporphyrin, its autoxidation product, predominates physiologically in the urine; decreased biliary excretion of coproporphyrin leading to a compensatory urinary excretion, so that the coproporphyrin ring isomer ratio (1:III) becomes a sensitive index for impaired liver function and intrahepatic cholestasis; and disturbed activity of hepatic uroporphyrinogen decarboxylase. In itself, secondary coproporphyrinuria is not associated with porphyria symptoms of a hepatologic-gastroenterologic, neurologic, or dermatologic order, even though coproporphyrinuria can occur with such symptoms. PMID: 3327428 Copyright Copyright ©2005-2009 Genome Alberta (Reference to original publication: Wishart DS, Knox C, Guo AC, et al. HMDB: a knowledgebase for the human metabolome. Nucleic Acids Res. 2009 37(Database issue):D603-610.) Source: Human Metabolome Database, Corproporphyrin I

LOINC Names Get Info

Fully-Specified Name: Coproporphyrin 1/Porphyrins.total:SFr:Pt:Stool:Qn:
Long Common Name: Coproporphyrin 1/Porphyrins.total in Stool
Short Name: Copro1 SFr Stl
Display Name: Coproporphyrin 1/Total porphyrins (Stl) [Molar fraction]
Consumer Name Alpha Get Info: Coproporphyrin 1/Total Porphyrins, Stool

Part Model Get Info

Component
Coproporphyrin 1/Porphyrins.total
LP285801-9
- Analyte
  Coproporphyrin 1/Porphyrins.total
  LP285801-9
  - Component Numerator
    Coproporphyrin 1
    LP18633-5
    - Component Numerator Core
      Coproporphyrin 1
      LP18633-5
    - Component Numerator Core Suffix
      NULL
  - Component Denominator
    Porphyrins.total
    LP32122-1
    - Component Denominator Core
      Porphyrins.total
      LP32122-1
    - Component Denominator Core Suffix
      NULL
- Challenge
  NULL
- Adjustment
  NULL
- Count
  NULL
Property
SFr
LP6866-0
Time
Pt
LP6960-1
- Time Core
  Pt
  LP6960-1
- Time Modifier
  NULL
System
Stool
LP7604-4
- System Core
  Stool
  LP7604-4
- Super System
  NULL
Scale
Qn
LP7753-9
Method
NULL

Basic Attributes

Class: CHEM
Type: Laboratory
First Released: Version 2.48
Last Updated: Version 2.48 (MIN)
Order vs. Observation: Both

Member of these Panels

LOINC	Long Common Name
74835-0	Porphyrin fractions panel - Stool

Language Variants Get Info

Tag	Language	Translation
cs-CZ	Czech (Czechia)	Koproporfyrin 1/porfyriny.celkové:Látkový podíl:Časový bod:Stolice:Kvantitativní:
el-GR	Greek (Greece)	Κοπροπορφυρίνη 1/Πορφυρίνες.ολικές:SFr:Pt:Κόπρανα:Qn: Synonyms: CHEM Pt Qn SFr Κόπρανα Κοπροπορφυρίνη Κοπροπορφυρίνη 1 Πορφυρίνες Πορφυρίνες.ολικές
es-ES	Spanish (Spain)	Coproporfirina 1/Niveles totales de porfirinas:Fraccion de sustancia:Punto temporal:Heces:Qn: Synonyms: Cuantitativo
es-MX	Spanish (Mexico)	Coproporfirina 1 / Porfirinas total:Fracción de sustancia:Punto temporal:Heces:Cuantitativo:
et-EE	Estonian (Estonia)	Koproporfüriin 1/porfüriinid.üld:SFr:Pt:St:Qn: Synonyms: Aine fraktsioon Juhuslik Kvantitatiivne Roe
fr-CA	French (Canada)	Coproporphyrine 1/Porphyrines.totales:Fraction de substance:Temps ponctuel:Selles:Quantitatif:
fr-FR	French (France)	Coproporphyrine 1/porphyrines totales:Fraction molaire:Ponctuel:Selle:Numérique:
fr-BE	French (Belgium)	Coproporphyrine 1/Porphyrines.totales:Fraction de substance:Temps ponctuel:Selles:Quantitatif: Synonyms: Fraction. Concentration
it-IT	Italian (Italy)	Coproporfirina 1/Porfirine.totali:SFr:Pt:Feci:Qn: Synonyms: Chimica Frazione di Sostanza Punto nel tempo (episodio)
nl-NL	Dutch (Netherlands)	coproporfyrine 1/porfyrinen.totaal:stoffractie:moment:feces:kwantitatief: Synonyms: ontlasting; feces
ru-RU	Russian (Russian Federation)	Копропорфирин 1/Порфирины.общий:МольДол:ТчкВрм:Фекалии:Колич: Synonyms: Количественный Мольная доля;Молярная доля Точка во времени;Момент
tr-TR	Turkish (Turkey)	Koproporfirin 1/Porfirinler.total:SubFr:Zmlı:Dışkı:Kant: Synonyms: Gaita; feçes
zh-CN	Chinese (China)	粪卟啉 I/卟啉.总计:物质的量分数:时间点:大便:定量型: Synonyms: Ⅰ Copro;Coproporph;四羧基卟啉 Copro1;粪卟啉 1;粪卟啉Ⅰ I Porph;卟啉;卟啉及相关物质;卟啉类及相关物质;成分 - 化学 - 卟啉及相关物质便;大肠运动;排便;粪便;肠运动克分子分数;摩尔分数全体数量全部共计化学;化学检验项目;化学检验项目类;化学类;化学试验;非刺激耐受型化学检验项目;非刺激耐受型化学检验项目类;非刺激耐受型化学试验;非刺激耐受型化学试验类卟啉总计可用数量表示的;定量性;数值型;数量型;连续数值型标尺总总和总数总量总额时刻;随机;随意;瞬间汇总

Example Units

Unit	Source
%	Example UCUM Units

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LOINC Copyright

Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.