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Part Description

LP95534-1   MPL gene
The MPL gene (MPL proto-oncogene, thrombopoietin receptor) [HGNC Gene ID:7217] is located on chromosome 1p34. In 1990 an oncogene, v-mpl, was identified from the murine myeloproliferative leukemia virus that was capable of immortalizing bone marrow hematopoietic cells from different lineages. In 1992 the human homologue, named, c-mpl, was cloned. Sequence data revealed that c-mpl encoded a protein that was homologous with members of the hematopoietic receptor superfamily. Presence of anti-sense oligodeoxynucleotides of c-mpl inhibited megakaryocyte colony formation. The ligand for c-mpl, thrombopoietin, was cloned in 1994. Thrombopoietin was shown to be the major regulator of megakaryocytopoiesis and platelet formation. The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs . TPO-R deficient mice were severely thrombocytopenic, emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation. Upon binding of thrombopoietin CD110 is dimerized and the JAK family of non-receptor tyrosine kinases, as well as the STAT family, the MAPK family, the adaptor protein Shc and the receptors themselves become tyrosine phosphorylated. [provided by RefSeq, Jul 2008] [NCBI Gene ID:4352] Source: National Center for Biotechnology Information (NCBI) Gene

LOINC Names Get Info

Fully-Specified Name
MPL gene mutations tested for:Prid:Pt:Bone mar:Nom:Molgen
Long Common Name
MPL gene mutations tested for in Bone marrow by Molecular genetics method Nominal
Short Name
MPL gene Mut Tested Mar
Display Name
MPL gene mutations tested for Molgen Nom (BM)
Consumer Name Alpha Get Info
MPL gene variants tested for, Bone marrow

Part Model Get Info

  • Component
    MPL gene mutations tested for
    LP229030-4
    • Analyte
      MPL gene mutations tested for
      LP229030-4
      • Component Numerator
        MPL gene mutations tested for
        LP229030-4
        • Component Numerator Core
          MPL gene
          LP95534-1
        • Component Numerator Core Suffix
          mutations tested for
          LP32421-7
      • Component Denominator
        NULL
         
        • Component Denominator Core
          NULL
           
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    Prid
    LP6850-4
  • Time
    Pt
    LP6960-1
  • System
    Bone mar
    LP7410-6
    • System Core
      Bone mar
      LP7410-6
    • Super System
      NULL
       
  • Scale
    Nom
    LP7750-5
  • Method
    Molgen
    LP6404-0

Basic Attributes

Class
MOLPATH.MUT
Type
Laboratory
First Released
Version 2.48
Last Updated
Version 2.48 (MIN)
Order vs. Observation
Both

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)Gen MPL testované mutace:Přítomnost nebo identita:Časový bod:Kostní dřeň:Nominální:Molekulární genetika
el-GRGreek (Greece)Γονίδιο MPL εξετασθείσες μεταλλάξεις:Prid:Pt:Μυελός των οστών:Nom:Μοριακή γενετική
Synonyms: MOLPATH MOLPATH.MUT Nom Prid Pt Γονίδιο Γονίδιο MPL εξετασθείσες μεταλλάξεις εξετασθέν για Μεταλλάξεις Μοριακή γενετική Μυελός των οστών Οστό
es-ESSpanish (Spain)Gen MPL Análisis de mutaciones para...:Presencia o identidad:Punto temporal:Médula ósea:Nom:Genética molecular
es-MXSpanish (Mexico)Mutaciones del gen MPL analizadas para:Presencia o identidad:Punto temporal:Médula ósea:Nominal:Genética molecular
fr-FRFrench (France)MPL gène mutations recherchées:Identification:Ponctuel:Moelle osseuse:Résultat nominal:Biologie moléculaire
it-ITItalian (Italy)MPL, gene, mutazioni testate per:Prid:Pt:Mid oss:Nom:Molgen
Synonyms: Gene MPL Genetica molecolare Midollo osseo Mutazione genica Patologia molecolare Presenza o Identità Punto nel tempo (episodio) testato
nl-NLDutch (Netherlands)MPL-gen geteste mutaties:identificator:moment:beenmerg:nominaal:moleculair genetisch onderzoek
Synonyms: molgen MPL gen
pl-PLPolish (Poland)MPL gen badanie w kierunku mutacji:obecność lub identyfikacja:punkt w czasie:szpik kostny:skala nominalna:genetyka molekularna
Synonyms: diagnostyka molekularna Gen MPL wynik kategorialny
pt-BRPortuguese (Brazil)MPL gene teste para mutações:Ident:Pt:MedOssea:Nom:Genética molecular
ru-RURussian (Russian Federation)MPL ген мутации тестирован на:ПрИд:ТчкВрм:Костный мозг:Ном:МолГен
Synonyms: Номинальный;Именной Присутствие или Идентификация тестирован;анализ проведен на;исследован на Точка во времени;Момент
tr-TRTurkish (Turkey)MPL geni mutasyonlar, test edilen:MevcKimlik:Zmlı:Kem il:Snf:Molgen
zh-CNChinese (China)MPL 基因 已测试的突变:存在与否或特征标识:时间点:骨髓:名义型:分子遗传学类实验室方法
Synonyms: C-MPL;CD110;MPLV;TPOR;OTTHUMP00000008582;thrombopoietin receptor;myeloproliferative leukemia virus oncogene;血小板生成素受体;促血小板生成素受体;骨髓增殖白血病病毒癌基因 分子病理学.基因突变;分子病理学.突变;分子病理学试验.基因突变;分子病理学试验.突变;分子病理学试验类.突变;基因突变;突变 分子病理学;分子病理学试验 分子遗传学;分子遗传学方法;分子遗传学类方法;分子遗传学类检验方法;包括 RFL、PCR 及其他方法在内，用于在分子基础上检测遗传属性的方法的大类;聚合酶链反应;聚合酶链式反应 分类型应答;分类型结果;名义性;名称型;名词型;名词性;标称性;没有自然次序的名义型或分类型应答 存在;存在与否;特征标识;身份;身份标识 已检测的;已检验的;经检测的;经检验的;经测试的;经过检测的;经过检验的;经过测试的 已检测的突变;已检验的突变;经检测的突变;经检验的突变;经测试的突变;经过检测的突变;经过检验的突变;经过测试的突变 时刻;随机;随意;瞬间 突变 突变类;基因突变 遗传基因;遗传因子;吉恩;生物基因 骨骼;骨头 髓

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CodeSystem lookup
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