75264-2

Blood group antibody screen [Presence] in Serum or Plasma by Low ionic strength saline (LISS)

Active

Term Description

Antibody screening is used to demonstrate unexpected antibodies (other than ABO) and is performed on both donors and recipients to help ensure compatibility between recipient antibodies and donor red cells. Low ionic strength saline (LISS) is a blood banking potentiating agent that works by decreasing the repelling charges between red cells (zeta potential), thus packing the reds cells closer together for increased antibody bridging. This then decreases the incubation time for the sensitization phase in the antibody screening. A downside to using LISS is that it enhances the expression of cold antibodies and auto-antibodies that may not be significant. In addition, the ratio of serum to red cells must be adhered to strictly to maintain the ionic strength of the mixture. If ionic strength is too high, false negatives may occur, and if it is too low, false positives due to complement binding may occur.

Fully-Specified Name

Component: Blood group antibody
Property: PrThr
Time: Pt
System: Ser/Plas
Scale: Ord
Method: Blood group antibody screen.LISS

Additional Names

Long Common Name: Blood group antibody screen [Presence] in Serum or Plasma by Low ionic strength saline (LISS)
Short Name: Bld gp Ab Scn SerPl Ql LISS
Display Name: Blood group antibody screen LISS Ql
Consumer Name Alpha Get Info: Blood group antibody screen, Blood

Example Answer List: LL360-9

Source: Regenstrief Institute

Answer	Code	Score	Answer ID
PositiveCopyright http://snomed.info/sct ID:10828004 Positive (qualifier value)			LA6576-8
NegativeCopyright http://snomed.info/sct ID:260385009 Negative (qualifier value)			LA6577-6

Basic Attributes

Class: BLDBK
Type: Laboratory
First Released: Version 2.48
Last Updated: Version 2.79 (NAM)
Change Reason: Release 2.79: COMPONENT: Triggered by Coll w SCT: Screen should be omitted from Component. It should be in Method.; Previous Releases: The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation: Both
Common Test Rank Get Info: 2564

Language Variants Get Info

Tag	Language	Translation
es-ES	Spanish (Spain)	Examen de anticuerpos de grupos sanguineos:PrThr:Punto temporal:Suero o Plasma:Ord:Tampón salino de fuerza iónica baja
es-MX	Spanish (Mexico)	Examen de anticuerpos del grupo sanguíneo:Presencia o umbral:Punto temporal:Suero o Plasma:Ordinal:Solución salina de baja fuerza iónica (LISS)
fr-FR	French (France)	Anticorps irréguliers (RAI) dépistage:Présence/Seuil:Ponctuel:Sérum/Plasma:Qualitatif:LISS
fr-CA	French (Canada)	Anticorps des groupes sanguins dépistage:Présence-Seuil:Temps ponctuel:Sérum/Plasma:Ordinal:Salin hypotonique
it-IT	Italian (Italy)	Gruppo sanguigno,anticorpo:PrThr:Pt:Siero/Plasma:Ord:Gruppo sanguigno, screening anticorpo.LISS Synonyms: Banca del sangue Gruppo sanguigno,screening anticorpo Plasma Presenza o Soglia Punto nel tempo (episodio) Screening anticorpo del guppo sanguigno Screening tossicologico Siero Siero o Plasma Soluzione a bassa forza ionica (LISS) Soluzione salina a bassa forza ionica (LISS)
nl-NL	Dutch (Netherlands)	bloedgroep antistofscreening:aanwezigheid:moment:serum of plasma:ordinaal:zoutoplossing met lage ionsterkte (LISS) Synonyms: LISS
pl-PL	Polish (Poland)	Skryning przeciwciał grup krwi:granica wykrywalności:punkt w czasie:surowica lub osocze:półilościowy:standaryzowany roztwór soli o niskiej sile jonowej
pt-BR	Portuguese (Brazil)	Triagem de anticorpos grupo sanguíneo::Pt:Soro/Plas:Ord:LISS
zh-CN	Chinese (China)	血型抗体:存在情况或阈值:时间点:血清/血浆:序数型:血型抗体筛查.LISS Synonyms: 低离子强度氯化钠水溶液;低离子强度氯化钠水溶液法;低离子强度氯化钠溶液;低离子强度氯化钠溶液法;低离子强度盐水;低离子强度盐水（Low ionic strenght saline，LISS）依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值）时刻;随机;随意;瞬间筛查筛查方法;筛查法;筛查试验筛查试验筛选试验血;全血血型抗体（Ab）血型抗体（Ab）筛查血型抗体（Ab）筛查.LISS（低离子强度盐溶液、低离子强度盐水）血库;血库检验;血库检验类;血库检验项目;血库检验项目类;血库类;血库试验;血库试验项目;血库试验项目类血清或血浆过筛过筛试验

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