Version 2.78

Term Description

The development of this panel for detecting Lupus Anticoagulant (LA) was shaped by the 2009 International Society of Thrombosis and Haemostasis (ISTH) and 2014 Clinical and Laboratory Standards Institute (CLSI) guidelines for lupus anticoagulant testing. They both recommend using two separate coagulation tests and identify dRVVT and aPPT as the two best choices. This aPPT & dRVVT panel is most closely aligned with the ISTH guidelines. The testing cascade starts with the use of the two above-named tests to screen for or verify a clotting abnormality, and if either is abnormal, reflexing to the same test with 1:1 pooled plasma (to exclude clotting factor deficiencies) and again with excess phospholipid (PL). Correction of the coagulopathy with excess phospholipid confirms the likelihood of LA. Neither published guidance nor laboratories agree on the order in which the two kinds of reflex tests should be done, and this panel does not take a position on that subject. Some laboratories report the absolute values of the test and some the normalized ratios. So LOINC includes both as alternatives. Only one or the other of the alternatives must be included in the panel report. A summary interpretation is required by both guidelines.
Source: Regenstrief LOINC

Panel Hierarchy

Details for each LOINC in Panel LHC-Forms

LOINC Name R/O/C Cardinality Example UCUM Units
75515-7 Lupus anticoagulant aPTT and dRVVT screening panel W Reflex
Indent6303-2 dRVVT (LA screen) R-a s
Indent15359-3 dRVVT actual/normal (normalized LA screen) R-a %
Indent93234-3 dRVVT in Platelet poor plasma by Coagulation assay --post heparin neutralization s
Indent75513-2 dRVVT with 1:1 PNP (LA mix) Rflx-a s
Indent75512-4 dRVVT with 1:1 PNP actual/normal (normalized LA mix) Rflx-a %
Indent93240-0 dRVVT factor substitution in Platelet poor plasma by Coagulation assay --immediately after 1:1 addition of normal plasma and heparin neutralization s
Indent57838-5 dRVVT W excess phospholipid (LA confirm) Rflx-a s
Indent68916-6 dRVVT W excess phospholipid actual/normal (normalized LA confirm) Rflx-a %
Indent93238-4 dRVVT excess phospholipid in Platelet poor plasma by Coagulation assay --post heparin neutralization s
Indent93239-2 dRVVT excess phospholipid actual/normal in Platelet poor plasma by Coagulation assay --post heparin neutralization %
Indent50410-0 dRVVT/dRVVT W excess phospholipid (screen to confirm ratio) O {ratio}
Indent75511-6 dRVVT W excess phospholipid percent correction O %
Indent34571-0 aPTT.lupus sensitive (LA screen) R-a s
Indent48022-8 aPTT.lupus sensitive actual/normal (normalized LA screen) R-a
Indent93235-0 aPTT.lupus sensitive in Platelet poor plasma by Coagulation assay --post heparin neutralization s
Indent75510-8 aPTT.lupus sensitive with 1:1 PNP (LA mix) Rflx-a s
Indent75509-0 aPTT.lupus sensitive with 1:1 PNP actual/Normal (normalized LA mix) Rflx-a %
Indent75506-6 aPTT.lupus sensitive W excess phospholipid (LA confirm) Rflx-a s
Indent75508-2 aPTT.lupus sensitive W excess phospholipid actual/Normal (normalized LA confirm) Rflx-a %
Indent93236-8 aPTT.lupus sensitive.excess phospholipid in Platelet poor plasma by Coagulation assay --post heparin neutralization s
Indent93237-6 aPTT.lupus sensitive.excess phospholipid actual/normal in Platelet poor plasma by Coagulation assay --post heparin neutralization %
Indent75884-7 aPTT.lupus sensitive/aPTT.lupus sensitive W excess phospholipid (screen to confirm ratio) O {Ratio}
Indent75507-4 aPTT.lupus sensitive W excess phospholipid percent correction O %
Indent75514-0 Lupus anticoagulant two screening tests W Reflex [interpretation] R-a

Fully-Specified Name

Component
Lupus anticoagulant two screening tests W Reflex panel
Property
-
Time
Pt
System
PPP
Scale
-
Method
Coag

Additional Names

Short Name
LA aPTT+dRVVT screen W reflex panel
Display Name
Lupus anticoagulant two screening tests W Reflex panel Coag (PPP)
Consumer Name Alpha Get Info
Lupus Anticoagulant Two Screening Tests W Reflex Panel, Blood

Basic Attributes

Class
PANEL.COAG
Type
Laboratory
First Released
Version 2.50
Last Updated
Version 2.67
Order vs. Observation
Order
Panel Type
Panel

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) Panel W Reflex test doble de cribado de anticoagulante lúpico:Propiedades mixtas (sólo paneles):Punto temporal:Plasma pobre en plaquetas:-:Coagulativo
es-MX Spanish (Mexico) Anticoagulante lúpico dos pruebas de detección W Reflex panel:-:Punto temporal:Plasma pobre en plaquetas:-:Ensayo de coagulación
fr-FR French (France) Anticoagulant circulant de type lupique deux test de dépistage panel:-:Ponctuel:Plasma pauvre en plaquettes:-:Coagulation
it-IT Italian (Italy) Lupus anticoagulante, panel secondo test di screening con Reflex:-:Pt:PPP:-:Coag
Synonyms: Panel secondo test di screening con Reflex per lup Plasma povero di piastrine Punto nel tempo (episodio) Secondo test di screening con Reflex per lupus ant Set di prescrizione per coagulazione Studio di coagulazione Test di coagulazione
nl-NL Dutch (Netherlands) lupus-anticoagulans twee screening testen met reflex panel:-:moment:plaatjesarm plasma:-:stollingsmethode
Synonyms: coagulatiemethode
pl-PL Polish (Poland) Antykoagulant tocznia dwa testy przesiewowe W Reflex panel:-:punkt w czasie:osocze ubogopłytkowe:-:test krzepnięcia
Synonyms: Antykoagulant Antykoagulant tocznia Antykoagulant tocznia dwa testy przesiewowe panel W Reflex Antykoagulant tocznia dwa testy przesiewowe W Reflex PPP
zh-CN Chinese (China) 带有伺机追加型项目的狼疮抗凝物质筛查试验两项组套:-:时间点:贫血小板血浆:-:凝血功能分析
Synonyms: 2 Asympt SCN 两 乏血小板血浆;Platelet poor plasma;PPP 倾斜试管;倾斜试管法;凝固测定;凝血功能测定;凝血测定;快速凝固试验;快速凝血试验;快速凝集试验 凝固防止剂 凝血功能;凝血功能试验;凝血过程;血液凝固;血液凝固功能;血液凝固过程 凝血抑制性抗体;凝血抑制抗体;抗磷脂抗体;狼疮抑制剂;狼疮抑制物;狼疮抑制物质;狼疮抗凝剂;狼疮抗凝物;磷脂抗体 医嘱套餐 医嘱套餐类 医嘱套餐组 医嘱组 医嘱组.凝血功能试验;凝血功能组套（组合、医嘱组、套餐、套餐医嘱、医嘱套餐、组合申请、组合项目）;凝血功能医嘱组类;凝血功能检验项目医嘱组;凝血功能检验项目医嘱组类;凝血功能试验医嘱组;凝血功能试验医嘱组类;凝血医嘱组;凝血医嘱组类;凝血检验项目医嘱组;凝血检验项目医嘱组类;凝血试验医嘱组;凝血试验医嘱组类;医嘱组.凝血;医嘱组.凝血功能;医嘱组.凝血功能检验项目;医嘱组.凝血检验项目;医嘱组.凝血试验;医嘱组类.凝血;医嘱组类.凝血功能;医嘱组类.凝血功能检验项目;医嘱组类.凝血功能试验;医嘱组类.凝血 医嘱组合 医嘱组合类 医嘱组套 医嘱组套类 医嘱组类 双 多重;多重型;多重标尺类型;多重精度类型 套餐 套餐医嘱 套餐医嘱组 套餐医嘱组类 实验室医嘱套餐 实验室医嘱套餐类 实验室医嘱组 实验室医嘱组合类 实验室医嘱组套 实验室医嘱组套类 实验室套餐医嘱组 实验室套餐医嘱组类 实验室检验项目医嘱组合类 实验室检验项目组合类 带有伺机追加型（视情况追加型、待机追加型、级联型、灵活追加型）项目的狼疮抗凝物质（狼疮抗凝剂、狼疮抗凝物）筛查试验两项（筛查两项、筛查试验二项、二项筛查试验、二项筛查） 带有伺机追加型（视情况追加型、待机追加型、级联型、灵活追加型）项目的狼疮抗凝物质（狼疮抗凝剂、狼疮抗凝物）筛查试验两项（筛查两项、筛查试验二项、二项筛查试验、二项筛查）组套（组合、医嘱组、套餐、套餐医嘱、医嘱套餐、组合申请、组合项目） 抗凝固剂 抗凝血剂 抗凝血剂;抗凝药物;抗凝药;抗凝制剂 无症状 无症状（Asymptomatic，Asympt） 无症状的 无症状筛查 时刻;随机;随意;瞬间 普查 普查试验 检验医嘱组合类 检验项目医嘱组合类 检验项目组合类 筛分 筛分试验 筛查（Screening，SCN） 筛查试验 筛选 筛选试验 组 组合 组合医嘱 组合类 组套 贰 防凝固剂 防凝结剂 阴凝剂 阻凝剂

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=75515-7
Questionnaire definition
https://fhir.loinc.org/Questionnaire/?url=http://loinc.org/q/75515-7