Version 2.77

Term Description

The lupus anticoagulant three screen panel is based primarily on the 2009 International Society of Thrombosis and Haemostasis (ISTH) and 2014 Clinical and Laboratory Standards Institute (CLSI) guidelines for detecting the presence of lupus anticoagulants (LA), with some modifications based on information from major laboratories that use three screening tests (PT, aPTT and dRVVT) as the first step in LA testing. The ISTH guidelines recommend using dRVVT as the first screening test and aPTT-LA as the second screening test, followed by reflex to mixing studies with 1:1 Pooled Normal Plasma and confirmatory testing with excess phospholipid (PL) if either of the screening tests are positive. The CLSI guidelines permit use of other screening tests in addition to aPTT and dRVVT, and also recommend changing the order of the tests to screening following by confirmatory and then mixing. Some major laboratories reflex to thrombin time (TT) and reptilase assays if any of the three screening tests have an abnormal result, so both of those tests are included in the panel. Both ISTH and CLSI recommend reporting quantitative results as the ratio of the patient result to the control result for each of the screening, mixing and confirmatory tests that are performed. However, they use different parameters for the control: ISTH recommends calculating the control based on pooled normal plasma (PNP), while CLSI recommends using the mean of the reference interval provided by the assay manufacturer. Many labs report either the actual patient result or the actual patient result and the actual/normal ratio, so we have included both options in the panel. In addition to the quantitative results, both guidelines recommend reporting a qualitative interpretation.
Source: Regenstrief LOINC

Panel Hierarchy

Details for each LOINC in Panel LHC-Forms

LOINC Name R/O/C Cardinality Example UCUM Units
75881-3 Lupus anticoagulant aPTT, dRVVT and PT screening panel W Reflex
Indent6303-2 dRVVT (LA screen) R-a s
Indent93234-3 dRVVT in Platelet poor plasma by Coagulation assay --post heparin neutralization C s
Indent15359-3 dRVVT actual/normal (normalized LA screen) R-a %
Indent75513-2 dRVVT with 1:1 PNP (LA mix) Rflx-a s
Indent75512-4 dRVVT with 1:1 PNP actual/normal (normalized LA mix) Rflx-a %
Indent93240-0 dRVVT factor substitution in Platelet poor plasma by Coagulation assay --immediately after 1:1 addition of normal plasma and heparin neutralization Rflx-a s
Indent57838-5 dRVVT W excess phospholipid (LA confirm) Rflx-a s
Indent68916-6 dRVVT W excess phospholipid actual/normal (normalized LA confirm) Rflx-a %
Indent93238-4 dRVVT excess phospholipid in Platelet poor plasma by Coagulation assay --post heparin neutralization Rflx-a s
Indent93239-2 dRVVT excess phospholipid actual/normal in Platelet poor plasma by Coagulation assay --post heparin neutralization Rflx-a %
Indent75511-6 dRVVT W excess phospholipid percent correction O %
Indent50410-0 dRVVT/dRVVT W excess phospholipid (screen to confirm ratio) O {ratio}
Indent34571-0 aPTT.lupus sensitive (LA screen) R-a s
Indent48022-8 aPTT.lupus sensitive actual/normal (normalized LA screen) R-a
Indent93235-0 aPTT.lupus sensitive in Platelet poor plasma by Coagulation assay --post heparin neutralization R-a s
Indent75510-8 aPTT.lupus sensitive with 1:1 PNP (LA mix) Rflx-a s
Indent75509-0 aPTT.lupus sensitive with 1:1 PNP actual/Normal (normalized LA mix) Rflx-a %
Indent75506-6 aPTT.lupus sensitive W excess phospholipid (LA confirm) Rflx-a s
Indent75508-2 aPTT.lupus sensitive W excess phospholipid actual/Normal (normalized LA confirm) Rflx-a %
Indent93236-8 aPTT.lupus sensitive.excess phospholipid in Platelet poor plasma by Coagulation assay --post heparin neutralization Rflx-a s
Indent93237-6 aPTT.lupus sensitive.excess phospholipid actual/normal in Platelet poor plasma by Coagulation assay --post heparin neutralization Rflx-a %
Indent75884-7 aPTT.lupus sensitive/aPTT.lupus sensitive W excess phospholipid (screen to confirm ratio) O {Ratio}
Indent75507-4 aPTT.lupus sensitive W excess phospholipid percent correction O %
Indent5902-2 Prothrombin time (PT) R-a s
Indent5894-1 Prothrombin time (PT) actual/Normal R-a %
Indent3243-3 Thrombin time Rflx-a s
Indent68325-0 Thrombin time actual/Normal Rflx-a %
Indent6683-7 Reptilase time Rflx-a s
Indent68326-8 Reptilase time actual/Normal Rflx-a %
Indent75882-1 Lupus anticoagulant three screening tests W Reflex [interpretation] R-a

Fully-Specified Name

Component
Lupus anticoagulant three screening tests W Reflex panel
Property
-
Time
Pt
System
PPP
Scale
-
Method
Coag

Additional Names

Short Name
LA aPTT+dRVVT+PT W Reflex PPP
Display Name
Lupus anticoagulant three screening tests W Reflex panel Coag (PPP)
Consumer Name Alpha Get Info
Lupus Anticoagulant Three Screening Tests W Reflex Panel, Blood

Basic Attributes

Class
PANEL.COAG
Type
Laboratory
First Released
Version 2.50
Last Updated
Version 2.67
Order vs. Observation
Order
Panel Type
Panel

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) Panel W Reflex test triple de cribado de anticoagulante lúpico:Propiedades mixtas (sólo paneles):Punto temporal:Plasma pobre en plaquetas:-:Coagulativo
es-MX Spanish (Mexico) Anticoagulante lúpico tres pruebas de detección W Reflex panel:-:Punto temporal:Plasma pobre en plaquetas:-:Ensayo de coagulación
fr-CA French (Canada) Anticoagulant circulant de type lupique trois tests de dépistage W Reflex panel:-:Temps ponctuel:Plasma pauvre en plaquettes:-:Test de coagulation
fr-FR French (France) Anticoagulant circulant de type lupique trois tests de dépistage W Reflex panel:-:Ponctuel:Plasma pauvre en plaquettes:-:Coagulation
it-IT Italian (Italy) Lupus anticoagulante, panel terzo test di screening con Reflex:-:Pt:PPP:-:Coag
Synonyms: Panel terzo test di screening con Reflex per lupus Plasma povero di piastrine Punto nel tempo (episodio) Set di prescrizione per coagulazione Studio di coagulazione Terzo test di screening con Reflex per lupus antic Test di coagulazione
nl-NL Dutch (Netherlands) lupus-anticoagulans drie screening testen met reflex panel:-:moment:plaatjesarm plasma:-:stollingsmethode
Synonyms: coagulatiemethode
zh-CN Chinese (China) 带有伺机追加型项目的狼疮抗凝物质筛查试验三项组套:-:时间点:贫血小板血浆:-:凝血功能分析
Synonyms: 3 Asympt SCN 乏血小板血浆;Platelet poor plasma;PPP 倾斜试管;倾斜试管法;凝固测定;凝血功能测定;凝血测定;快速凝固试验;快速凝血试验;快速凝集试验 凝固防止剂 凝血功能;凝血功能试验;凝血过程;血液凝固;血液凝固功能;血液凝固过程 凝血抑制性抗体;凝血抑制抗体;抗磷脂抗体;狼疮抑制剂;狼疮抑制物;狼疮抑制物质;狼疮抗凝剂;狼疮抗凝物;磷脂抗体 医嘱套餐 医嘱套餐类 医嘱套餐组 医嘱组 医嘱组.凝血功能试验;凝血功能组套（组合、医嘱组、套餐、套餐医嘱、医嘱套餐、组合申请、组合项目）;凝血功能医嘱组类;凝血功能检验项目医嘱组;凝血功能检验项目医嘱组类;凝血功能试验医嘱组;凝血功能试验医嘱组类;凝血医嘱组;凝血医嘱组类;凝血检验项目医嘱组;凝血检验项目医嘱组类;凝血试验医嘱组;凝血试验医嘱组类;医嘱组.凝血;医嘱组.凝血功能;医嘱组.凝血功能检验项目;医嘱组.凝血检验项目;医嘱组.凝血试验;医嘱组类.凝血;医嘱组类.凝血功能;医嘱组类.凝血功能检验项目;医嘱组类.凝血功能试验;医嘱组类.凝血 医嘱组合 医嘱组合类 医嘱组套 医嘱组套类 医嘱组类 叁 多重;多重型;多重标尺类型;多重精度类型 套餐 套餐医嘱 套餐医嘱组 套餐医嘱组类 实验室医嘱套餐 实验室医嘱套餐类 实验室医嘱组 实验室医嘱组合类 实验室医嘱组套 实验室医嘱组套类 实验室套餐医嘱组 实验室套餐医嘱组类 实验室检验项目医嘱组合类 实验室检验项目组合类 带有伺机追加型（视情况追加型、待机追加型、级联型、灵活追加型）项目的狼疮抗凝物质（狼疮抗凝剂、狼疮抗凝物）筛查试验三项（筛查三项、三项筛查试验、三项筛查） 带有伺机追加型（视情况追加型、待机追加型、级联型、灵活追加型）项目的狼疮抗凝物质（狼疮抗凝剂、狼疮抗凝物）筛查试验三项（筛查三项、三项筛查试验、三项筛查）组套（组合、医嘱组、套餐、套餐医嘱、医嘱套餐、组合申请、组合项目） 抗凝固剂 抗凝血剂 抗凝血剂;抗凝药物;抗凝药;抗凝制剂 无症状 无症状（Asymptomatic，Asympt） 无症状的 无症状筛查 时刻;随机;随意;瞬间 普查 普查试验 检验医嘱组合类 检验项目医嘱组合类 检验项目组合类 筛分 筛分试验 筛查（Screening，SCN） 筛查试验 筛选 筛选试验 组 组合 组合医嘱 组合类 组套 防凝固剂 防凝结剂 阴凝剂 阻凝剂

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=75881-3
Questionnaire definition
https://fhir.loinc.org/Questionnaire/?url=http://loinc.org/q/75881-3