LOINC
Version 2.68

75881-3Lupus anticoagulant aPTT, dRVVT and PT screening panel W ReflexActive

Term Description

The lupus anticoagulant three screen panel is based primarily on the 2009 International Society of Thrombosis and Haemostasis (ISTH) and 2014 Clinical and Laboratory Standards Institute (CLSI) guidelines for detecting the presence of lupus anticoagulants (LA), with some modifications based on information from major laboratories that use three screening tests (PT, aPTT and dRVVT) as the first step in LA testing. The ISTH guidelines recommend using dRVVT as the first screening test and aPTT-LA as the second screening test, followed by reflex to mixing studies with 1:1 Pooled Normal Plasma and confirmatory testing with excess phospholipid (PL) if either of the screening tests are positive. The CLSI guidelines permit use of other screening tests in addition to aPTT and dRVVT, and also recommend changing the order of the tests to screening following by confirmatory and then mixing. Some major laboratories reflex to thrombin time (TT) and reptilase assays if any of the three screening tests have an abnormal result, so both of those tests are included in the panel. Both ISTH and CLSI recommend reporting quantitative results as the ratio of the patient result to the control result for each of the screening, mixing and confirmatory tests that are performed. However, they use different parameters for the control: ISTH recommends calculating the control based on pooled normal plasma (PNP), while CLSI recommends using the mean of the reference interval provided by the assay manufacturer. Many labs report either the actual patient result or the actual patient result and the actual/normal ratio, so we have included both options in the panel. In addition to the quantitative results, both guidelines recommend reporting a qualitative interpretation.
Source: Regenstrief LOINC

Panel Hierarchy
Details for each LOINC in Panel LHC-Forms

LOINC Name R/O/C Cardinality Example UCUM Units
75881-3 Lupus anticoagulant aPTT, dRVVT and PT screening panel W Reflex
Indent6303-2 dRVVT (LA screen) R-a s
Indent93234-3 dRVVT in Platelet poor plasma by Coagulation assay --post heparin neutralization s
Indent15359-3 dRVVT actual/normal (normalized LA screen) R-a %
Indent75513-2 dRVVT with 1:1 PNP (LA mix) Rflx-a s
Indent75512-4 dRVVT with 1:1 PNP actual/normal (normalized LA mix) Rflx-a %
Indent93240-0 dRVVT factor substitution in Platelet poor plasma by Coagulation assay --immediately after 1:1 addition of normal plasma and heparin neutralization s
Indent57838-5 dRVVT W excess phospholipid (LA confirm) Rflx-a s
Indent68916-6 dRVVT W excess phospholipid actual/normal (normalized LA confirm) Rflx-a %
Indent93238-4 dRVVT excess phospholipid in Platelet poor plasma by Coagulation assay --post heparin neutralization s
Indent93239-2 dRVVT excess phospholipid actual/normal in Platelet poor plasma by Coagulation assay --post heparin neutralization %
Indent75511-6 dRVVT W excess phospholipid percent correction O %
Indent50410-0 dRVVT/dRVVT W excess phospholipid (screen to confirm ratio) O
Indent34571-0 aPTT.lupus sensitive (LA screen) R-a s
Indent48022-8 aPTT.lupus sensitive actual/normal (normalized LA screen) R-a
Indent93235-0 aPTT.lupus sensitive in Platelet poor plasma by Coagulation assay --post heparin neutralization s
Indent75510-8 aPTT.lupus sensitive with 1:1 PNP (LA mix) Rflx-a s
Indent75509-0 aPTT.lupus sensitive with 1:1 PNP actual/Normal (normalized LA mix) Rflx-a %
Indent75506-6 aPTT.lupus sensitive W excess phospholipid (LA confirm) Rflx-a s
Indent75508-2 aPTT.lupus sensitive W excess phospholipid actual/Normal (normalized LA confirm) Rflx-a %
Indent93236-8 aPTT.lupus sensitive.excess phospholipid in Platelet poor plasma by Coagulation assay --post heparin neutralization s
Indent93237-6 aPTT.lupus sensitive.excess phospholipid actual/normal in Platelet poor plasma by Coagulation assay --post heparin neutralization %
Indent75884-7 aPTT.lupus sensitive/aPTT.lupus sensitive W excess phospholipid (screen to confirm ratio) O {Ratio}
Indent75507-4 aPTT.lupus sensitive W excess phospholipid percent correction O %
Indent5902-2 Prothrombin time (PT) R-a s
Indent5894-1 Prothrombin time (PT) actual/Normal R-a %
Indent3243-3 Thrombin time Rflx-a s
Indent68325-0 Thrombin time actual/Normal Rflx-a %
Indent6683-7 Reptilase time Rflx-a s
Indent68326-8 Reptilase time actual/Normal Rflx-a %
Indent75882-1 Lupus anticoagulant three screening tests W Reflex [interpretation] R-a

Fully-Specified Name

Component
Lupus anticoagulant three screening tests W Reflex panel
Property
-
Time
Pt
System
PPP
Scale
-
Method
Coag

Additional Names

Short Name
LA aPTT+dRVVT+PT W Reflex PPP
Display Name
Lupus anticoagulant three screening tests W Reflex panel Coag (PPP)

Basic Attributes

Class
PANEL.COAG
Type
Laboratory
First Released
Version 2.50
Last Updated
Version 2.67
Order vs. Observation
Order
Panel Type
Panel

Language Variants Get Info

zh-CNChinese (CHINA)
带有伺机追加型项目的狼疮抗凝物质筛查试验三项组套:-:时间点:贫血小板血浆:-:凝血功能分析
nl-NLDutch (NETHERLANDS)
lupus-anticoagulans drie screening testen met reflex panel:-:moment:plaatjesarm plasma:-:stollingsmethode
fr-FRFrench (FRANCE)
Anticoagulant circulant de type lupique trois tests de dépistage W Reflex panel:-:Ponctuel:Plasma pauvre en plaquettes:-:Coagulation
it-ITItalian (ITALY)
Lupus anticoagulante, panel terzo test di screening con Reflex:-:Pt:PPP:-:Coag
es-ESSpanish (SPAIN)
Panel W Reflex test triple de cribado de anticoagulante lúpico:Propiedades mixtas (sólo paneles):Punto temporal:Plasma pobre en plaquetas:-:Coagulativo

LOINC FHIR® API Example - CodeSystem Request Get Info

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=75881-3